Serum bisphenol A concentration and sex hormone levels in men

Inverse associations were observed between serum bisphenol-A (BPA) concentration and androstenedione, free testosterone, and free androgen index and a positive association between serum BPA concentration and sex hormone-binding globulin.

Qin Zhou, Ph.D., Maohua Miao, Ph.D., Maomei Ran, M.M., Ling Ding, Ph.D., Lan Bai, M.M., Tingting Wu, M.M., Wei Yuan, M.D., Ph.D., Ersheng Gao, M.D., M.P.H., Jintao Wang, M.D., Ph.D., Guohong Li, M.D., De-Kun Li, M.D., Ph.D.

Volume 100, Issue 2, Pages 478-482, August 2013


To evaluate the association between serum bisphenol-A (BPA) concentration and sex hormone levels in men.

Cross-sectional study.

Not applicable.

A total of 290 men with or without BPA exposure in the workplace.


Main Outcome Measure(s):
Serum sex hormone levels.

After adjustment for potential confounders using linear regression, increasing serum BPA concentration was statistically significantly associated with [1] decreased androstenedione levels, [2] decreased free testosterone levels, [3] decreased free androgen index, and [4] increased sex hormone-binding globulin levels. Comparison of hormone levels between workers exposed and unexposed to BPA showed similar associations.

Exposure to a high BPA level may impact sex hormone levels in men.

  • Audrey Gaskins

    This is a well-conducted cross-sectional study on serum levels of BPA and sex hormone levels in men that adds valuable insight into the detrimental effects of BPA on male reproductive heath. Unlike many studies in the US, the main source of exposure to BPA in this study was occupational as the men with the highest levels of BPA were male workers in a petrochemical company. While this allowed for observing a wide range of BPA levels, were the authors not concerned about other chemicals that might come along with BPA that these workers might also have been exposed to? Were any other chemicals measured in serum?

  • Interesting article that adds more information on the negative effects of BPA. This study demonstrates the negative effects of high serum BPA levels. The study subjects, however, are significantly at risk for higher serum BPA levels due to the high level of workplace exposure, compared to the general consumer.

    Ultimately, it would be interesting to see how these decreased levels affect spermatogenesis, fertility rates, future development of hypogonadism as these men age compared to their controls.

    I wish someone would do a study on the serum BPA levels in the serum and the hormones based on the use of BPA containing products for food and drink products.

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