Serum bisphenol A concentration and sex hormone levels in men

Capsule:
Inverse associations were observed between serum bisphenol-A (BPA) concentration and androstenedione, free testosterone, and free androgen index and a positive association between serum BPA concentration and sex hormone-binding globulin.

Authors:
Qin Zhou, Ph.D., Maohua Miao, Ph.D., Maomei Ran, M.M., Ling Ding, Ph.D., Lan Bai, M.M., Tingting Wu, M.M., Wei Yuan, M.D., Ph.D., Ersheng Gao, M.D., M.P.H., Jintao Wang, M.D., Ph.D., Guohong Li, M.D., De-Kun Li, M.D., Ph.D.

Volume 100, Issue 2, Pages 478-482, August 2013

Abstract:

Objective:
To evaluate the association between serum bisphenol-A (BPA) concentration and sex hormone levels in men.

Design:
Cross-sectional study.

Setting:
Not applicable.

Patient(s):
A total of 290 men with or without BPA exposure in the workplace.

Intervention(s):
None.

Main Outcome Measure(s):
Serum sex hormone levels.

Result(s):
After adjustment for potential confounders using linear regression, increasing serum BPA concentration was statistically significantly associated with [1] decreased androstenedione levels, [2] decreased free testosterone levels, [3] decreased free androgen index, and [4] increased sex hormone-binding globulin levels. Comparison of hormone levels between workers exposed and unexposed to BPA showed similar associations.

Conclusion(s):
Exposure to a high BPA level may impact sex hormone levels in men.

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