Pregnancy outcomes decline in recipients over age 44 An analysis of 27959 fresh donor oocyte in vitro fertilization cycles from the Society for Assisted Reproductive Technology

Capsule:
Based on recent U.S. summary data, donor oocyte recipients have stable rates of pregnancy outcomes before age 45, after which there is a small but steady and significant decline.

Authors:
Jason S. Yeh, M.D.; Ryan G. Steward, M.D., Annie M. Dude, M.D., Ph.D., Anish A. Shah, M.D., M.H.S., James M. Goldfarb, M.D., Suheil J. Muasher, M.D.

Volume 101, Issue 5, Pages 1331–1336.e1

Abstract:

Objective:
To use a large and recent national registry to provide an updated report on the effect of recipient age on the outcome of donor oocyte in vitro fertilization (IVF) cycles.

Design:
Retrospective cohort study.

Setting:
United States national registry for assisted reproductive technology.

Patient(s):
Recipients of donor oocyte treatment cycles between 2008 and 2010, with cycles segregated into five age cohorts: ≤34, 35 to 39, 40 to 44, 45 to 49, and ≥50 years.

Intervention(s):
None.

Main Outcome Measure(s):
Implantation, clinical pregnancy, live-birth, and miscarriage rates.

Result(s):
In donor oocyte IVF cycles, all age cohorts ≤39 years had similar rates of implantation, clinical pregnancy, and live birth when compared with the 40- to 44-year-old reference group. Patients in the two oldest age groups (45 to 49, ≥50 years) experienced statistically significantly lower rates of implantation, clinical pregnancy, and live birth compared with the reference group. Additionally, all outcomes in the ≥50-year-old group were statistically significantly worse than the 45- to 49-year-old group, demonstrating progressive decline with advancing age.

Conclusion(s):
Recent national registry data suggest that donor oocyte recipients have stable rates of pregnancy outcomes before age 45, after which there is a small but steady and significant decline.

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