Effect of fibroids not distorting the endometrial cavity on the outcome of in vitro fertilization treatment A retrospective cohort study

A retrospective cohort study demonstrates that intramural fibroids with diameter larger than 2.85 cm have a negative effect on in vitro fertilization/intracytoplasmic sperm injection delivery rates.

Lei Yan, M.D., Lingling Ding, M.D., Chunyan Li, M.D., Yu Wang, Rong Tang, M.D., Ph.D., Zi-Jiang Chen, M.D.Ph.D.

Volume 101, Issue 3, Pages 716-721.e6, March 2014


To investigate the effect of fibroids that do not distort the endometrial cavity on IVF/intracytoplasmic sperm injection (ICSI) outcomes and to identify certain fibroid subgroups that may be deleterious to fertility outcomes.

Retrospective cohort study.

University-based reproductive medicine center.

A total of 10,268 patients undergoing IVF/ICSI between 2009 and 2011 in our unit.

Transvaginal ultrasound and hysteroscopy; controlled ovarian hyperstimulation and IVF/ICSI; strict matching criteria.

Main Outcome Measure(s):
Cycle cancellation, clinical pregnancy, miscarriage, and delivery rates.

We included 249 patients with fibroids who underwent IVF/ICSI. Higher day 3 FSH levels were found in women with fibroids compared with in control subjects. No significant differences were found in IVF/ICSI outcomes between the two groups. Patients with intramural fibroids with the largest diameter

Our results suggest that although non-cavity-distorting fibroids do not affect IVF/ICSI outcomes, intramural fibroids greater than 2.85 cm in size significantly impair the delivery rate of patients undergoing IVF/ICSI.

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