Incidence of hypertension stroke coronary heart disease, and diabetes in women who have delivered after in vitro fertilization A population based cohort study from Sweden

Capsule:
In a cohort study, the incidence of hypertension increased in women after IVF pregnancies, suggesting that these women could have a propensity to develop cardiovascular disease later in life.

Authors:
Eli Westerlund, M.D., Ph.D., Lena Brandt, B.Sc., Outi Hovatta, M.D., Håkan Wallén, M.D., Anders Ekbom, M.D., Peter Henriksson, M.D.

Volume 102, Issue 4, Pages 1096-1102

Abstract:

Objective:
To compare the incidence of hypertension, stroke, coronary heart disease, and diabetes in women who have delivered after in vitro fertilization (IVF) with those who delivered after natural conception.

Design:
A cohort study in Sweden between 1990 and 2008.

Setting:
Sweden.

Patient(s):
23,498 women who had given birth to a child after IVF and 116,960 individually matched women.

Intervention(s):
None.

Main Outcome Measure(s):
Incidence rates of hypertension, diabetes, stroke, and coronary heart disease in both groups.

Result(s):
Inpatient and outpatient diagnoses of hypertension, stroke, coronary heart disease, and diabetes were identified by linkage to the Swedish National Patient Register. The mean time of follow-up was 8.6 years in both groups. Multivariable analysis showed that hypertension had a higher incidence in IVF mothers with a hazard ratio (HR) of 1.27, 95% confidence interval (CI) 1.13–1.41, as compared with mothers from the Medical Birth Register. There was a trend to a higher incidence of stroke (HR 1.27; 95% CI, 0.96–1.68), but the incidence of coronary heart disease and diabetes did not differ.

Conclusion(s):
Hypertension was more prevalent in the IVF group, which suggests that these women should be aware of their blood pressure and cardiovascular risk profile.

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