Association between appendicectomy in females and subsequent pregnancy rate: A cohort study

Capsule:
This was a large cohort study to determine the association between appendicectomy and subsequent pregnancy rate in females. Appendicectomy was associated with increased subsequent pregnancy rates.

Authors:
Li Wei, Ph.D., Thomas MacDonald, M.D., Sami Shimi, M.D.

Volume 98, Issue 2 , Pages 401-405, August 2012

Abstract:

Objective:
To study whether subsequent pregnancy rate is reduced after appendicectomy.

Design:
A cohort study was carried out in the General Practice Research Database, a United Kingdom primary care database.

Setting:
University hospital.

Patient(s):
Female patients who underwent appendicectomy between 1986 and 2009 and appropriate comparators were followed until first pregnancy.

Intervention(s):
None.

Main Outcome Measure(s):
The association between appendicectomy and subsequent pregnancy was determined by Cox regression models.

Result(s):
The analyses included 76,426 appendicectomy patients, with 152,852 comparators from the database. There were 30,030 pregnancies (39.3%) in the appendicectomy cohort and 43,321 (28.3%) in the comparator cohort during a mean (SD) follow-up of 10.5 (6.6) years. Adjusted hazard ratios for subsequent birth rates were 1.54 (95% confidence interval, 1.52–1.56).

Conclusion(s):
Appendicectomy was associated with increased subsequent pregnancy rate in this study. This suggests that a history of appendicectomy is not associated with impaired fertility.

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