Age at menarche a predictor of diminished ovarian function

Capsule:
There are significant associations between age at menarche and the risk of diminished ovarian function in infertile women.

Authors:
Andrea Weghofer, M.D., Ph.D., M.S., M.B.A., Ann Kim, M.S., David H. Barad, M.D., M.S., Norbert Gleicher, M.D.

Volume 100, Issue 4, Pages 1039-1043, October 2013

Abstract:

Objective:
To investigate whether age at menarche is associated with functional ovarian reserve (FOR) later in life.

Design:
Retrospective cohort study.

Setting:
Fertility center.

Patient(s):
Five hundred and two infertile women.

Intervention(s):
None.

Main Outcome Measure(s):
Levels of menarcheal age, antimüllerian hormone (AMH), follicle-stimulating hormone (FSH), and functional ovarian reserve.

Result(s):
The mean age of the patients was 38.9 ± 4.9 years, and their mean level of AMH was 1.4 ± 2.0 ng/mL and of FSH was 10.7 ± 6.1 mIU/mL. Their current age-specific diminished functional ovarian reserve (DFOR) was statistically significantly associated with early menarche, defined as age <13 years. Logistic regression analysis, adjusting for race, affirmed the higher likelihood of early age at menarche in infertile patients with DFOR. When women with DFOR were grouped into quartiles, early menarche (<25th percentile) was associated with statistically significantly higher DFOR risk than late menarche (>75th percentile).

Conclusion(s):
This study demonstrates a statistically significant impact of age at menarche on DFOR risk later in life among infertile women. The occurrence of menarche may relate to follicular pool size and/or speed of follicle recruitment, which in turn is predictive of occurrence of DFOR later in life.

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