First reported case of sextuplets conceived via letrozole for ovulation induction

Capsule:
Monitoring of follicular growth should be considered in ovulation induction with letrozole to reduce the risk of high-order multiple gestations.

Authors:
Gunwant Warraich, M.D., Tannys D.R. Vause, M.D.

Volume 103, Issue 2, Pages 535-536

Abstract:

Objective:
To report the first case of sextuplets conceived via letrozole during ovulation induction.

Design:
Case report.

Setting:
Private fertility clinic.

Patient(s):
32-year-old female with a history of secondary infertility and polycystic ovary syndrome.

Intervention(s):
Letrozole, 7.5 mg, on cycle days 3–7 after a progesterone-induced menses.

Main Outcome Measure(s):
Clinical pregnancy.

Result(s):
Sexchorionic-sexamniotic pregnancy.

Conclusion(s):
High-order multiple gestations are possible with letrozole ovulation induction, so patients should be counseled appropriately and follicle monitoring considered.

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