Lipidomics as an emerging tool to predict endometrial receptivity

Lipidomics can help to predict endometrial receptivity; prostaglandins E2 and F2a are abundant during the window of implantation, and they can serve as biomarkers to define the receptive phase of the endometrium.

Felipe Vilella, Ph.D., Leslie B. Ramirez, B.S., Carlos Simon, M.D.

Volume 99, Issue 4, Pages 1100-1106, 15 March 2013


From the first histological dating methods to the new „–omics‟ technologies there has been a lot of effort put into understanding and characterising receptive endometrium. The development of new diagnostic approaches to using biological fluids has opened up a new field of investigation in non-invasive endometrial diagnosis techniques. Moreover, improvements in the field of mass spectrometry and nuclear magnetic resonance have made the precise detection of lipids possible; these organic molecules are involved in important functions such as modulating energy reserves, forming structural features, and promoting regulatory functions. Developments in endometrial receptivity diagnosis using lipidomics are discussed in this review paper. In summary, the results currently available indicate that prostaglandins E2 and F2are particularly abundant during the window of implantation and that they might serve to nurse the blastocyst at the time of embryo implantation; they may also serve as important biomarkers to define the receptive phase of the endometrium. The importance of understanding the mechanisms that influence the production of these individual PGs in the endometrium is clinically relevant as it may shed light on the sequence of events that leads to successful embryo implantation.

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