Soy food intake and treatment outcomes of women undergoing assisted reproductive technology

Capsule:
Pretreatment intake of soy foods and soy isoflavones was positively related to the probability of live birth in a prospective cohort of women undergoing assisted reproduction.

Authors:
Jose C. Vanegas, M.D., Myriam C. Afeiche, Ph.D., Audrey J. Gaskins, Sc.D., Lidia Mínguez-Alarcón, Ph.D., Paige L. Williams, Ph.D., Diane L. Wright, D.L., Ph.D., Thomas L. Toth, M.D., Russ Hauser, M.D., Sc.D., Jorge E. Chavarro, M.D., Sc.D.

Volume 103, Issue 3, Pages 749-755

Abstract:

Objective:
To study the relation of dietary phytoestrogens intake and clinical outcomes of women undergoing infertility treatment with the use of assisted reproductive technology (ART).

Design:
Prospective cohort study.

Setting:
Fertility center.

Patient(s):
A total of 315 women who collectively underwent 520 ART cycles from 2007 to 2013.

Intervention(s):
None.

Main Outcome Measure(s):
Implantation, clinical pregnancy, and live birth rates per initiated cycle.

Result(s):
Soy isoflavones intake was positively related to live birth rates in ART. Compared with women who did not consume soy isoflavones, the multivariable-adjusted odds ratios of live birth (95% confidence interval) for women in increasing categories of soy isoflavones intake were 1.32 (0.76–2.27) for women consuming 0.54–2.63 mg/d, 1.87 (1.12–3.14) for women consuming 2.64–7.55 mg/d, and 1.77 (1.03–3.03) for women consuming 7.56–27.89 mg/d.

Conclusion(s):
Dietary soy intake was positively related to the probability of having a live birth during infertility treatment with ART.

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