Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor initiating stem cells

Wednesday, June 1, 2016
We discuss whether efficient transduction and subsequent elimination of fibroid tumor-initiating stem cells during debulking of tumor cells will aid in completely eradicating the tumor as well as decreasing the likelihood of recurrence.

Read More

The PROMISe trial A pilot randomized placebo controlled trial of magnetic resonance guided focused ultrasound for uterine fibroids

Tuesday, March 1, 2016
A placebo effect may explain some of the improvement in fibroid symptoms after magnetic resonance-guided focused ultrasound among women with uterine fibroids.

Read More

Are we advancing in our scientific understanding and therapeutic improvement of uterine fibroids or not

Thursday, July 10, 2014
The cellular, genetic, and hormonal understanding of uterine fibroids is rapidly growing, but the therapeutic options remain similar. Are we really advancing the field?

Read More

Cervical neoplasia related factors and decreased prevalence of uterine fibroids among a cohort of African American women

Tuesday, December 31, 2013
As in two previous studies, a measure of cervical neoplasia was associated with a decreased risk of fibroids (patients with a history of cervical treatment had a 39% adjusted reduction in odds).

Read More

2-methoxyestradiol causes functional repression of transforming growth factor-β3 signaling by ameliorating Smad and non-Smad signaling pathways in immortalized uterine fibroid cells

Friday, June 8, 2012
The profibrotic response of transforming growth factor (TGF) b3 in fibroid cells is mediated by Smad-dependent and Smad-independent PI3K/Akt/mTOR pathways. 2-Methoxyestradiol inhibits TGF-b3 profibrotic effects in fibroid cells by ameliorating both Smad-dependent and Smad-independent signaling pathways.

Read More

Identification and Characterization of the Human Leiomyoma Side Population as Putative Tumor-Initiating Cells

Friday, June 8, 2012
The side population method was used to isolate and identify putative tumor-initiating leiomyoma stem cells as demonstrated by their ability to differentiate in vitro and reconstruct leiomyoma tissue in vivo.

Read More

Roles of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas

Thursday, June 7, 2012
PDCD-4 is unexpectedly elevated in leiomyomas, but normal myometrium does not express the protein; the expected inverse correlation of microRNA-21 and its target PDCD-4 is absent in fibroids.

Read More

Translate »