Impact of multinucleated blastomeres on embryo developmental competence morphokinetics and aneuploidy

Tuesday, April 26, 2016

Hanna Balakier, Ph.D., Agata Sojecki, M.Sc., Gelareh Motamedi, M.Sc., Clifford Librach, M.D.…

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Study of nucleation status in the second cell cycle of human embryo and its impact on implantation rate

Monday, March 21, 2016

Jesus Aguilar, Ph.D., Irene Rubio, Ph.D., Elkin Muñoz, M.D., Ph.D., Antonio Pellicer, M.D., Ph.D., Marcos Meseguer, Ph.D.…

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Time lapse deselection model for human day 3 in vitro fertilization embryos The combination of qualitative and quantitative measures of embryo growth

Tuesday, March 1, 2016
This study presents a deselection model for human in vitro fertilization embryos independent of the insemination method, the qualitative component being more accurate when coupled with a quantitative component.

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Combination of metabolism measurement and a time lapse system provides an embryo selection method based on oxygen uptake and chronology of cytokinesis timing

Monday, February 15, 2016

Alberto Tejera, Ph.D., Damia Castelló, Ph.D., Jose Maria de los Santos, Ph.D., Antonio Pellicer, M.D., Jose Remohí, M.D., Marcos Meseguer, Ph.D.…

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Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time lapse system

Monday, February 1, 2016
Blastocyst formation and implantation prediction based on late morphokinetic parameters was developed by using an integrated time-lapse monitoring system.

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Improved implantation rates of day 3 embryo transfers with the use of an automated time lapse enabled test to aid in embryo selection

Monday, February 1, 2016
An automated noninvasive time-lapse embryo assessment test can be used together with embryo morphology to increase implantation rates after day 3 transfer.

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Time lapse the remaining questions to be answered

Monday, February 1, 2016

Marcos Meseguer, Ph.D

Volume 105, Issue 2, Pages 295-296


Reflections on “Does the addition of time-lapse morphokinetics in the selection of embryos for transfer improve pregnancy rates?…

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Noninferiority randomized controlled trial comparing embryo development using media developed for sequential or undisturbed culture in a time lapse setup

Monday, November 30, 2015
In this randomized sibling study we found no differences in blastocyst development between sequential and single-step media.

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Morphokinetics as a predictor of self correction to diploidy in tripronucleated intracytoplasmic sperm injection derived human embryos

Tuesday, September 1, 2015
Tripronucleated-ICSI human embryos (TPN) display different morphokinetic behaviour according to ploidy; TPN-ICSI that self-correct to diploidy are morphokinetically closer to correctly fertilized embryos. The morphokinetic variable t5 can predict ploidy.

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New strategy for diagnosing embryo implantation potential by combining proteomics and time lapse technologies

Wednesday, June 24, 2015
We developed a diagnostic tool using a combination of proteomic fingerprinting and time-lapse morphokinetic analysis to select embryos for transfer according to their implantation potential.

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Clinical significance of intercellular contact at the four cell stage of human embryos and the use of abnormal cleavage patterns to identify embryos with low implantation potential A time lapse study

Monday, June 1, 2015
Reduced intercellular contact in four-cell stage human embryos leads to compromised subsequent development and implantation potential. Implantation rates could be improved by not selecting embryos showing abnormal cleavage patterns.

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External validation of a time lapse prediction model

Monday, March 30, 2015
This external validation study failed to replicate the performance of the time-lapse published prediction model, but it should inspire each center to build its own prediction model.

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Is there a relationship between time-lapse parameters and embryo sex

Friday, January 30, 2015
An analysis of embryo sex by means of time-lapse monitoring identified different cleavage timings. The sex ratio could be affected by the embryo selection method for transfer based on kinetic parameters.

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Prevalence consequence and significance of reverse cleavage by human embryos viewed with the use of the Embryoscope time lapse video system

Monday, July 14, 2014
This study investigated the prevalence and significance of reverse cleavage by human embryos observed via time-lapse monitoring. Embryos showing reverse cleavage were associated with compromised subsequent development and implantation potential.

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Clinical validation of embryo culture and selection by morphokinetic analysis A randomized controlled trial of the EmbryoScope

Wednesday, July 9, 2014
An alternative strategy for embryo selection based on a multivariable morphokinetic model combined with continuous incubation in an integrated timelapse monitoring system improves the clinical results.

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Frequency of embryo multinucleation detected by time lapse system and its impact on pregnancy outcome

Thursday, June 19, 2014
The presence of multinucleation in 2-cell stage embryos seems to have a negative impact on pregnancy outcome.

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Increasing the probability of selecting chromosomally normal embryos by time lapse morphokinetics analysis

Thursday, February 20, 2014
A retrospective study demonstrates differences in the kinetics between chromosomally normal and abnormal embryos, providing a selection tool that increases the probability of selecting normal embryos through a noninvasive method.

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A time to look back analysis of morphokinetic characteristics of human embryo development

Wednesday, November 27, 2013
We define the times associated with morphological changes that occur in embryo development based on time lapse. Subgroups of embryos were compared and related with blastocyst formation and implantation.

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Hatching of in vitro fertilized human embryos is influenced by fertilization method

Thursday, October 31, 2013
We describe two distinct mechanisms of in vitro hatching related to fertilization method and demonstrate that hatching pattern is associated with fertilization method, but not with clinical pregnancy.

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Comparison of embryo morphokinetics after in vitro fertilization intracytoplasmic sperm injection in smoking and nonsmoking women

Friday, May 31, 2013
The comparison of embryo morphokinetics after IVF-ICSI cycles according to female smoking status showed that early embryo development is impaired by female smoking, leading to poor IVF outcome.

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Selection of high potential embryos using time lapse imaging The era of morphokinetics

Monday, March 18, 2013
Time-lapse is a promising tool with the potential to revolutionize embryology and IVF success rates. It provides an uninterrupted information flow on embryo development not otherwise available through standard evaluation.

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Effect of oxygen concentration on human embryo development evaluated by time lapse monitoring

Friday, March 1, 2013
With the use of time-lapse monitoring, to evaluate human embryo development, we describe a stage-dependent adverse response to atmospheric oxygen.

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Limited Implantation Success of Direct Cleaved Human Zygotes A Time Lapse Study

Thursday, November 29, 2012
In a multicenter retrospective study, embryos with direct cleavage from two to three cells (5 hours) had a statistically significantly lower implantation rate than embryos with a normal cleavage pattern.

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Time dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos

Thursday, September 27, 2012
We need new and more effective techniques of embryo selection. Oxygen consumption changes depending on the developmental stage, quality, and implantation success. Our observations indicate that oxygen consumption pattern could be a useful new marker of embryo quality.

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