Experimental methods to preserve male fertility and treat male factor infertility

Monday, February 1, 2016
This article describes experimental stem cell and gene therapies that might be used to treat male factor infertility.

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Stro 1 CD44 as putative human myometrial and fibroid stem cell markers

Monday, June 29, 2015
Stro-1/CD44 surface markers were used to isolate and identify human myometrial/fibroid stem cells as demonstrated by their ability to differentiate in vitro and regenerate fibroid-like tissue in vivo.

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Contribution of different bone marrow derived cell types in endometrial regeneration using an irradiated murine model

Monday, June 1, 2015
The BMDCs might improve uterine tissue as a valuable source for endometrial restoration.

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Adult somatic cells to the rescue Nuclear reprogramming and the dispensability of gonadal germ cells

Tuesday, December 31, 2013
Men and women who are genetically fertile can become infertile due to several extrinsic factors. Patient-specific pluripotent stem cells represent one potential cure for these non-genetic forms of infertility.

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Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1 5 8 signaling

Thursday, October 31, 2013
Bone morphogenetic protein 4 increased oocyte formation from adult mouse ovary-derived oogonial stem cells via activation of Smad1/5/8 signaling and key meiosis commitment genes.

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Is neonatal uterine bleeding involved in the pathogenesis of endometriosis as a source of stem cells

Friday, August 30, 2013
Endometrial bleeding in the neonate, an event totally neglected by modern investigators, may play a role in the pathogenesis of at least early onset endometriosis and represent a potential source of endometrial stem cells. The bleeding is a well-established phenomenon occurring at the end of the first week, but is more often occult than visible. The structure and functional obstruction of the endocervical canal in the fetus at term suggest increased likelihood of retrograde flow of the endometrial shedding.

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MicroRNA miR 145 inhibits proliferation invasiveness and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors

Thursday, March 28, 2013
MicroRNA miR-145 inhibits proliferation, invasiveness, and the stem cell phenotype of endometriotic cells by targeting multiple cytoskeletal elements and pluripotency factors, emerging as a novel target for therapeutic approaches.

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Peripheral blood stem cell transplants do not result in endometrial stromal engraftment

Monday, February 4, 2013
Peripheral blood stem cell transplants did not result in endometrial engraftment in human and non-human primate models.

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Haploid Sperm-Like Cells Created From Human Stem Cells – Sept 2012 Author Interview video

Sunday, September 16, 2012

September 2012 Featured Author Interview  – Drs.

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The next (re)generation of ovarian biology and fertility in women: is current science tomorrow’s practice?

Thursday, June 28, 2012
We present an overview of gametogenesis from stem cells, with emphasis on generation of human oocytes, future research objectives for this area of work, and potential clinical applications involving human oogonial stem cells.

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Somatic stem cells and tissue engineering shed light on unsolved clinical issues in reproductive medicine: in stem cells we trust

Thursday, June 28, 2012
Three experts in regenerative medicine explore the evidence and expanding future clinical applicability of the human ovarian and endometrial stem cell population, and tissue engineering of reproductive organs and tissues.

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Orthotopic grafting of cryopreserved prepubertal testicular tissue: in search of a simple yet effective cryopreservation protocol

Friday, May 4, 2012
Solid-surface vitrification resulted in success rates similar to conventional uncontrolled slow freezing inpreserving the integrity and function of prepubertalmouse testicular tissue.

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