Azoospermia factor region microdeletions were not detected in Slovenian men with IRSA. Our comparisons with previous studies show that Y chromosome microdeletions are most likely not associated with IRSA.
Microarray and real-time polymerase chain reaction (PCR) studies reveal that microRNAs are differentially expressed in normal versus spermatogenically impaired males and have therapeutic potential for the development of biomarkers for male infertility.
Reflections on “Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial” by Roth et al.
Adding recombinant follicle-stimulating hormone to human chorionic gonadotropin treatment protocols in adolescent/young adult men with hypogonadotropic hypogonadism results in normal testicular growth and may hasten induction of spermatogenesis.
This study suggests that in thalassemic men, blood transfusion is associated with significant acute enhancement of sperm parameters and increased concentrations of serum T, LH, FSH, and IGF-1.
We performed a literature review of the genetic etiology of Klinefelter syndrome, its effect on spermatogenesis, and the health of children born from men with Klinefelter syndrome following assisted reproductive technology.
Assessing complete AZFa deletion is important in azoospermic men, but routine assessment of either USP9Y or DDX3Y microdeletions is unjustified, owing to their rarity and inconsistent impact on spermatogenesis.
Human BRDT is the only BET gene expressed exclusively in testicular germ cells. The BRDT protein is expressed in spermatocytes, round spermatids, elongated spermatids, and ejaculated spermatozoa.
Suppression of spermatogenesis before testis grafting allows spermatogenesis recovery, whereas control tissue degenerates. Testis tissue xenografting could be an important tool for study and preservation of fertility in adult azoospermia.
Although their testes showed severe fibrosis and hyalinization, spermatogonia were observed in 4 of 22 Klinefelter syndrome patients with no sperm recovered after TESE.
Solid-surface vitrification resulted in success rates similar to conventional uncontrolled slow freezing inpreserving the integrity and function of prepubertalmouse testicular tissue.
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