Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells

Tuesday, March 1, 2016
Our data provide evidence that rapamycin (mTOR), particularly mTORC1, controls the glycolytic and oxidative profiles of human Sertoli cells. The mTOR signaling may be a pharmacologic target to control male reproductive potential.

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Predictors of spermatogenesis in radical orchiectomy specimen and potential implications for patients with testicular cancer

Wednesday, February 24, 2016

Authors:
Ohad Shoshany, M.D., Yariv Shtabholtz, M.D., Eran Schreter, M.D., Maxim Yakimov, M.D., Haim Pinkas, M.D., Anat Stein, Ph.D., Jack Baniel, M.D., Shay Golan, M.D.…

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Dysregulation of apoptotic pathway candidate genes and proteins in infertile azoospermia patients

Tuesday, September 1, 2015
An altered apoptotic pathway in impaired spermatogenic cases leads to infertility in males.

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Mutational screening of NR5A1 gene encoding steroidogenic factor 1 SF 1 in cryptorchidism and male factor infertility and functional analysis of seven undescribed mutations

Monday, June 29, 2015
This study shows that NR5A1 mutations are a novel cause of severe primary spermatogenic impairment and suggests that isolated cryptorchidism might be another phenotype associated with disruption of NR5A1-mediated pathways.

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Levels of liver x receptors in testicular biopsies of patients with azoospermia

Wednesday, July 30, 2014
This study shows differences in mRNA levels of the transcription factors LXRs and some of their downstream genes in testes of men with nonobstructive azoospermia and obstructive azoospermia.

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New insights into the expression profile and function of micro ribonucleic acid in human spermatozoa

Wednesday, June 25, 2014
Human spermatozoa contain a stable population of miRNAs potentially related to embryo development and spermatogenesis.

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Impact of lymphoma treatments on spermatogenesis and sperm deoxyribonucleic acid A multicenter prospective study from the CECOS network

Monday, June 2, 2014
Lymphoma treatments had highly damaging effects on spermatogenesis and sperm chromatin quality. Mean pretreatment sperm concentrations were recovered at 12months after doxorubicin, bleomycin, vinblastine, darcarbacine (ABVD) or ABVD + radiotherapy, but at 24 months after doxorubicin, cyclophosphamide, vincristine, prednisone(CHOP) ormechlorethamine, oncovin, procarbazine, prednisone (MOPP) therapies.

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MicroRNAs and spermatogenesis

Sunday, June 1, 2014
This review article summarizes expression and functions of miRNAs during spermatogenesis and their importance in maintaining male fertility, and as potential biomarkers for male factor infertility.

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Levels of the retinoic acid synthesizing enzyme ALDH1A2 are lower in testicular tissue from men with infertility

Monday, March 31, 2014
Levels of aldehyde dehydrogenase-1A2 (ALDH1A2), which synthesizes retinoic acid, are significantly reduced in testicular tissue from men with infertility compared with controls, suggesting an association between ALDH1A2 and male infertility.

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Phenotypic differences in mosaic Klinefelters patients as compared with nonmosaic Klinefelters patients

Monday, March 31, 2014
Men with mosaic Klinefelter syndrome (KS) seem to be more well androgenized than their non-mosaic KS counterparts, both with respect to hormones and sperm in the ejaculate.

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Cancer treatment and male fertility effects of therapy and current and future management options

Thursday, October 31, 2013
Cancer treatments are detrimental to spermatogenesis. This series reviews effects of anticancer therapies on male fertility, current and future approaches to determine sperm health, and gives recommendations for patient management.

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Effects of chemotherapy and radiotherapy on spermatogenesis in humans

Thursday, October 31, 2013
Short- and long-term effects of radiotherapy, cytotoxic cancer chemotherapy, and biologic targeted therapies on human spermatogenesis are summarized and interpreted based on kinetics of spermatogenesis and recovery from stem cells.

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Impact of chemotherapy and radiotherapy for testicular cancer on spermatogenesis and sperm DNA a multicenter prospective study from CECOS Network

Friday, August 30, 2013
Adjuvant treatments for testicular germ cell tumors have drastic effects on spermatogenesis and sperm chromatin quality; pretreatment values were recovered >12 months after >2 BEP cycles or after radiotherapy.

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Claudin 11 and connexin 43 display altered spatial patterns of organization in men with primary seminiferous tubule failure compared with controls

Friday, August 30, 2013
Claudin-11 and connexin-43 protein organization is impaired in men with primary seminiferous tubule failure compared with controls, suggesting that disorganization of the Sertoli cell junctions is involved in spermatogenic failure.

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Effect of rejuvenation hormones on spermatogenesis

Friday, May 31, 2013
Testosterone and anabolic androgenic steroids suppress spermatogenesis. Clomiphene citrate, HGH/IGF-1, hCG, and aromatase inhibitors offer a protective effect for spermatogenesis, with either a neutral or positive overall effect.

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Y chromosome azoospermia factor region microdeletions are not associated with idiopathic recurrent spontaneous abortion in a Slovenian population association study and literature review

Tuesday, April 30, 2013
Azoospermia factor region microdeletions were not detected in Slovenian men with IRSA. Our comparisons with previous studies show that Y chromosome microdeletions are most likely not associated with IRSA.

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Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments

Thursday, March 28, 2013
Microarray and real-time polymerase chain reaction (PCR) studies reveal that microRNAs are differentially expressed in normal versus spermatogenically impaired males and have therapeutic potential for the development of biomarkers for male infertility.

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The Significance of insulin-like factor 3 as a marker of intratesticular testosterone

Wednesday, January 2, 2013
Reflections on "Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial" by Roth et al.

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Addition of recombinant follicle-stimulating hormone to human chorionic gonadotropin treatment in adolescents and young adults with hypogonadotropic hypogonadism promotes normal testicular growth…

Thursday, September 27, 2012
Adding recombinant follicle-stimulating hormone to human chorionic gonadotropin treatment protocols in adolescent/young adult men with hypogonadotropic hypogonadism results in normal testicular growth and may hasten induction of spermatogenesis.

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Haploid Sperm-Like Cells Created From Human Stem Cells – Sept 2012 Author Interview video

Sunday, September 16, 2012

September 2012 Featured Author Interview  – Drs.

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Acute Effects of Blood transfusion on Pituitary Gonadal Axis and Sperm Parameters in Adolescents and Young Menwith Thalassemia Major: A Pilot Study

Thursday, June 21, 2012
This study suggests that in thalassemic men, blood transfusion is associated with significant acute enhancement of sperm parameters and increased concentrations of serum T, LH, FSH, and IGF-1.

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The genetic origin of Klinefelter syndrome and its effect on spermatogenesis

Tuesday, June 12, 2012
We performed a literature review of the genetic etiology of Klinefelter syndrome, its effect on spermatogenesis, and the health of children born from men with Klinefelter syndrome following assisted reproductive technology.

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Screening for partial AZFa microdeletions in the Y chromosome of infertile men – Is it of clinical relevance?

Wednesday, June 6, 2012
Assessing complete AZFa deletion is important in azoospermic men, but routine assessment of either USP9Y or DDX3Y microdeletions is unjustified, owing to their rarity and inconsistent impact on spermatogenesis.

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Expression of BET genes in testis of men with different spermatogenic impairments

Thursday, May 31, 2012
Human BRDT is the only BET gene expressed exclusively in testicular germ cells. The BRDT protein is expressed in spermatocytes, round spermatids, elongated spermatids, and ejaculated spermatozoa.

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Suppression of spermatogenesis before grafting increases survival and supports resurgence of spermatogenesis in adult mouse testis

Thursday, May 31, 2012
Suppression of spermatogenesis before testis grafting allows spermatogenesis recovery, whereas control tissue degenerates. Testis tissue xenografting could be an important tool for study and preservation of fertility in adult azoospermia.

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Presence of spermatogonia in 47,XXY men with no spermatozoa recovered after testicular sperm extraction

Thursday, May 24, 2012
Although their testes showed severe fibrosis and hyalinization, spermatogonia were observed in 4 of 22 Klinefelter syndrome patients with no sperm recovered after TESE.

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Orthotopic grafting of cryopreserved prepubertal testicular tissue: in search of a simple yet effective cryopreservation protocol

Friday, May 4, 2012
Solid-surface vitrification resulted in success rates similar to conventional uncontrolled slow freezing inpreserving the integrity and function of prepubertalmouse testicular tissue.

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