Impact of female age and nulligravidity on fecundity in an older reproductive age cohort

Wednesday, June 1, 2016
Women experience a significant reduction in fecundity and an increase in the probability of infertility in the late thirties. At any age >30 years, women, who have never conceived before, have a lower probability of conception.

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Coenzyme Q dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging

Tuesday, September 1, 2015
Coenzyme Q (CoQ)-dependent mitochondrial activity in granulosa cells reduces with aging and is restored via supplementation, indicating that functional CoQ10 deficit is the main underlying cause for oxidative phosphorylation dysfunction.

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Maternal undernutrition induces premature reproductive senescence in adult female rat offspring

Monday, December 29, 2014
An adverse uterine nutritional environment during pregnancy results in premature reproductive senescence in adult rats.

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Validation of the power model of ovarian nongrowing follicle depletion associated with aging in women

Thursday, February 20, 2014
In an independent set of ovarian nongrowing follicle counts, the power model of ovarian nongrowing follicle depletion was determined to be an excellent fit to the observed counts.

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Race ethnic disparities in reproductive age An examination of ovarian reserve estimates across four race ethnic groups of healthy regularly cycling women

Tuesday, December 31, 2013
In a healthy, multiethnic sample, a significant race/ethnicity-by-age interaction was observed, suggesting African-American women may have lower AMH at younger ages but experience less of a reduction in AMH with age.

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The aging oocyte Can mitochondrial function be improved

Wednesday, January 2, 2013
We describe the role of mitochondrial dysfunction in ovarian senescence and suggest a treatment to improve reproductive outcome with mitochondrial nutrients.

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Telomeres and Human Reproduction

Wednesday, January 2, 2013
Telomere dynamics differ between the female and male germ lines: oocytes have short telomeres, and their erosion recapitulates the reproductive aging phenotype, and telomere length in sperm increases with age.

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Aging gonads glands and gametes Immutable or partially reversible changes

Wednesday, January 2, 2013
Decreased ovarian testosterone production, granulosa cell dysfunction, oocyte telomere shortening and mitochondrial defects, and sperm DNA fragmentation all contribute to reproductive aging. Mitigating strategies are discussed.

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Testing and interpreting measures of ovarian reserve A committee opinion

Thursday, November 29, 2012
There is fair evidence against the recommendation that any ovarian reserve test should be used as a sole criterion for the use of ART.

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Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging

Thursday, May 10, 2012
STRAW + 10 recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria, recommended application regardless of women’s age, ethnicity, body size or lifestyle characteristics and identified seven research priorities.

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