Association between the seminal plasma proteome and sperm functional traits

Tuesday, March 1, 2016
Seminal plasma proteome reflects sperm mitochondrial defects, acrosome alterations, and DNA fragmentation. Altered proteins and biological functions were identified, and a panel of biomarkers was proposed for sperm functional traits.

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Differences in the seminal plasma proteome are associated with oxidative stress levels in men with normal semen parameters

Thursday, July 30, 2015
Seminal plasma proteome reflects semen lipid peroxidation status, with the expression of proteins related to reactive oxygen species metabolism. These proteins may be used as biomarkers for semen oxidative stress.

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New strategy for diagnosing embryo implantation potential by combining proteomics and time lapse technologies

Wednesday, June 24, 2015
We developed a diagnostic tool using a combination of proteomic fingerprinting and time-lapse morphokinetic analysis to select embryos for transfer according to their implantation potential.

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Omics as a window to view embryo viability

Friday, January 30, 2015
Omics technologies offer several noninvasive platforms for the investigation of biomarkers for embryo viability.

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Long term effects of repeated superovulation on ovarian structure and function in rhesus monkeys

Wednesday, July 9, 2014
A rhesus monkey model indicates that repeated controlled ovarian hyperstimulation could potentially affect the development and function of ovarian cells in the long term.

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Sperm proteomics Fertility diagnostic testing beyond the semen analysis

Sunday, June 1, 2014
Reflections on "Acute epididymitis induces alterations in sperm protein composition" by Pilatz et al.

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Towards the identification of a subset of unexplained infertility A sperm proteomic approach

Tuesday, May 13, 2014
Altered sperm proteome was observed with respect to poor blastocyst development and in vitro fertilization outcome in donor oocyte cycles despite normal sperm testing parameters.

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Differential seminal plasma proteome according to semen retrieval in men with spinal cord injury

Monday, September 30, 2013
Spinal cord injury is responsible for alterations in the seminal protein profile, leading to enrichment of a number of different gene ontology functions that may account for decreased fertility.

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A new way of investigating abnormal semen quality in men with spinal cord injury

Monday, September 30, 2013
Reflections on "Differential seminal plasma proteome according to semen retrieval in men with spinal cord injury" by da Silva et al.

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Proteomic analysis of seminal plasma from infertile patients with oligoasthenoteratozoospermia due to oxidative stress and comparison with fertile volunteers

Wednesday, July 31, 2013
The largest proteomic data set to date of seminal plasma from idiopathic oligoasthenoteratozoospermia (iOAT) and fertile subjects is presented, with 46 proteins implicated in oxidative stress and immune response in iOAT.

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Two dimensional differential in gel electrophoresis based proteomics of male gametes in relation to oxidative stress

Thursday, March 28, 2013
Proteomic analysis shows that differences in protein expression in spermatozoa producing higher levels of ROS may play a role in the pathophysiology of male infertility.

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Proteomic analysis and sperm physiopathology The two dimensional difference in gel electrophoresis approach

Thursday, March 28, 2013
Reflections on Hamada et al. "Two-Dimensional Differential In-Gel Electrophoresis-based proteomics of male gametes in relation to oxidative stress"

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The use of genomics proteomics and metabolomics in identifying biomarkers of male infertility

Monday, March 18, 2013
Biomarkers hold the keys to accurate diagnosis and treatment of male factor infertility. Their discovery is critical in eliminating invasive testing in the infertile male while developing novel targets for treatment.

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Biomarkers for ectopic pregnancy and pregnancy of unknown location

Monday, March 18, 2013
Novel biomarkers for ectopic pregnancy and/or pregnancy of unknown location could have clinical utility, but none are currently validated. A biomarker test will likely be made of multiple markers and may include newly discovered markers.

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Embryology in the era of proteomics

Monday, March 18, 2013
A review of the contribution of proteomic technologies in the identification of the human embryonic secretome.

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Proteomic analysis of seminal plasma in adolescents with and without varicocele

Wednesday, January 2, 2013
Normal semen analysis may not reflect important alterations in protein levels in the seminal plasma. A classic proteomics approach shows that unbalanced apoptosis may prevent normal spermatogenesis in the adolescent varicocele.

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What proteomic analysis of semen can tell us

Wednesday, January 2, 2013
Reflections on Zylbersztejn DS et al. "Proteomic analysis of seminal plasma in adolescents with and without varicocele"

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Proteomic Biomarkers for Ovarian Cancer risk in Women with Polycystic Ovary Syndrome A Systematic Review and Biomarker Database Integration

Thursday, November 29, 2012
The biomarkers calreticulin, fibrinogen-γ, superoxide dismutase, vimentin, malate dehydrogenase, and lamin B2 could help improve our understanding of the links between polycystic ovary syndrome (PCOS) and ovarian cancer (OC) and could potentially be used to identify subgroups of women with PCOS at increased risk of OC. More studies are required to further evaluate the role these biomarkers play in women with PCOS and OC.

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Impact of maternal aging on the molecular signature of human cumulus cells

Thursday, November 29, 2012
Cumulus cell gene and protein expression are impacted by maternal aging.

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Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis

Friday, June 8, 2012
Proteomic analysis of neurotrophins within the functional layer of the endometrium identified two factors that are expressed differentially in the eutopic endometrium of women with endometriosis compared to controls.

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Proteomic approach in the identification of fertility pattern in seminal plasma of fertile men

Thursday, May 31, 2012
We present a proteomic approach to identify a panel of common proteins in fertile men by using the LTQ-Orbitrap mass spectrometer.

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