Protocols to induce ovulation and progesterone block experiments

Tuesday, April 12, 2016

Author:
Daniela Galliano, MD, PhD

Abstract:

Clomiphene citrate (CC) was an emerging area of research in the 1960s.…

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Differential expression of vascular endothelial growth factor angiogenic factors in different endometrial compartments in women who have an elevated progesterone level before oocyte retrieval during in vitro fertilization Embryo transfer treatment

Tuesday, September 29, 2015
Altered expression of vascular endothelial growth factor angiogenic factors in peri-implantation endometrium may provide an explanation for the impairment of endometrial receptivity in women who have high P levels before oocyte retrieval.

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High responders and patients with a good prognosis are not immune to the negative impact on live birth rate of elevated P on the day of triggering

Monday, June 1, 2015
Reflections on "Are good prognosis patient and embryo characteristics protective from the negative effect of elevated progesterone on the day of HCG trigger?" by Hill et al.

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Perfluoroalkyl substances and ovarian hormone concentrations in naturally cycling women

Wednesday, April 29, 2015
Among 178 naturally cycling women, concentrations of perfluorooctane sulfonate and perfluorooctanesulfonic acid were inversely associated with salivary E2 and P concentrations. Associations were only evident in nulliparous women.

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Impairment of male reproductive function after sleep deprivation

Wednesday, April 29, 2015
Sleep loss can promote marked changes in the male reproductive system in rodents, affecting especially the spermatic function by means of NO pathway modulation.

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Timing luteal support in assisted reproductive technology A systematic review

Monday, March 30, 2015
Initiation of progesterone for luteal support may impact pregnancy rates (PRs). Starting progesterone before oocyte retrieval or 6 days after retrieval likely decreases PRs.

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Progesterone to follicle index is better correlated with in vitro fertilization cycle outcome than blood progesterone level

Friday, February 27, 2015
The progesterone-to-follicle index has a linear and inverse relationship to cycle outcome, unlike blood progesterone, which is detrimental only at high levels.

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Metaanalysis of estradiol for luteal phase support in in vitro fertilization intracytoplasmic sperm injection

Friday, January 30, 2015
This meta-analysis suggests that estradiol addition during the luteal phase does not improve in vitro fertilization/intracytoplasmic sperm injection outcomes through oral medication, even with different daily doses.

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Assessment of anovulation in eumenorrheic women Comparison of ovulation detection algorithms

Wednesday, July 30, 2014
Anovulation prevalence among eumenorrheic women varies greatly by algorithm. Urinary LH surge algorithms, such as used in fertility monitors, identified more anovulatory cycles compared with methods utilizing serum P.

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Current clinical irrelevance of luteal phase deficiency A committee opinion

Sunday, March 30, 2014
This committee opinion addresses controversies regarding the diagnosis and potential treatment of luteal phase inadequacy.

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Luteal phase support for frozen embryo transfer cycles Intramuscular or vaginal progesterone

Thursday, February 20, 2014
This editorial focuses on frozen embryo transfer (FET) or donor oocyte embryo transfer where hormonal therapy is used for endometrial preparation and no functional corpus luteum is present.

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Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short antagonist protocol A prospective cohort study

Thursday, February 20, 2014
Progesterone (P) level at oocyte retrieval was inversely associated with pregnancy rates: as P levels increased, pregnancy rates decreased. The odds ratio for nonpregnancy was clinically significant when P was 12 ng/mL.

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Subcutaneous progesterone versus vaginal progesterone gel for luteal phase support in in vitro fertilization a noninferiority randomized controlled study

Tuesday, December 31, 2013
Luteal phase supportwith a newsubcutaneous progesterone preparation provided pregnancy rates similar to progesterone vaginal gel in IVF patients. Safety and tolerability profile were equivalent.

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Progesterone elevation does not compromise pregnancy rates in high responders a pooled analysis of in vitro fertilization patients treated with recombinant FSH GnRH antagonist in six trials

Wednesday, November 27, 2013
Incidence of elevated P increases with ovarian response, and elevated P (>1.5 ng/mL) is independently associated with a decreased chance of pregnancy in low to normal, but not high, responders.

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Progesterone luteal support after ovulation induction and intrauterine insemination a systematic review and meta analysis

Thursday, October 31, 2013
Progesterone for luteal support after ovulation induction IUI was associated with increased likelihood of pregnancy and live birth in gonadotropin cycles but not in clomiphene citrate (CC) cycles.

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A randomized trial comparing the endometrial effects of daily subcutaneous administration of 25 mg and 50 mg progesterone in aqueous preparation

Friday, August 30, 2013
In mock donor-egg assisted reproduction technology cycles, daily subcutaneous administration of 25 mg or 50 mg progesterone reproduces the physiologic secretory transformation of the endometrium seen in the luteal phase.

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Early luteal phase endocrine profile is affected by the mode of triggering final oocyte maturation and the luteal phase support used in recombinant FSH GnRH antagonist IVF cycles

Friday, August 30, 2013
In oocyte donors triggered with a bolus of GnRHa, gonadotropin and steroid levels during the early luteal phase differed significantly according to the type of luteal phase support used after triggering.

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Early initiation of GnRH antagonist treatment results in a more stable endocrine milieu during the mid and late follicular phases an RCT comparing GnRH antagonist initiation…

Friday, August 30, 2013
Early initiation of GnRH antagonist cotreatment for IVF results in more stable levels of E2 and LH during the mid- and late-follicular phases.

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Involvement of the ganglion cholinergic receptors in gonadotropin releasing hormone catecholamines and progesterone release in rat ovary

Friday, May 31, 2013
Ganglionic cholinergic stimulation produces changes in ovarian release of progesterone, gonadotropin-releasing hormone, noradrenaline, and adrenaline; the ovarian nerve plexus regulates these mechanisms through the release of different neurotransmitters.

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Progesterone vaginal ring versus vaginal gel for luteal support with in vitro fertilization A randomized comparative study

Tuesday, April 30, 2013
Luteal supplementation with a weekly progesterone vaginal ring or daily vaginal gel provided similar high clinical pregnancy rates in in vitro fertilization.

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Kisspeptin stimulates progesterone secretion via the Erk1 2 mitogen activated protein kinase signaling pathway in rat luteal cells

Thursday, March 28, 2013
Kisspeptin could augment progesterone secretion via stimulating key steroidogenic enzymes and phosphorylate Erk1/2 mitogen-activated protein kinase in cultured luteal cells.

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Endometrin as Luteal Phase Support in Assisted Reproduction

Wednesday, January 2, 2013
Endometrin monotherapy provided comparable pregnancy rates (PRs) in fresh autologous and fresh donor oocyte cycles. The addition of P in oil to endometrin improved PRs in frozen transfer cycles.

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Aromatase Inhibitors for the Treatment of Endometriosis

Thursday, November 29, 2012
A review is presented of the role of aromatase in the pathogenesis of endometriosis, discuss the pharmacology of aromatase inhibitors, and examine clinical applications of aromatase inhibitors for endometriosis treatment.

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When Should Progesterone be Stopped in IVF Cycles?: Author Interview

Sunday, October 7, 2012
october 2012 author interview on new research on when to stop progesterone treatment in IVF cycles

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Early progesterone cessation after in vitro fertilization intracytoplasmic sperm injection A randomized, controlled trial

Thursday, September 27, 2012
Luteal phase supplementation with vaginal progesterone after in vitro fertilization/intracytoplasmic sperm injection can be safely withdrawn at 5 weeks’ gestation.

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Women with Reduced Ovarian Reserve or Advanced Maternal Age have an Altered Follicular Environment

Thursday, September 27, 2012
Women with reduced ovarian reserve or advanced maternal age have altered follicular cell metabolism, which is reflected in follicular fluid composition. This may represent a mechanism for reduced oocyte quality.

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Progesterone dependent Regulation of Endometrial Cannabinoid Receptor Type 1 CB1-R mRNA Expression is Disrupted in Women with Endometriosis and in Isolated Stromal Cells Exposed to …

Thursday, September 27, 2012
Endometrial cannabinoid receptor type 1 expression during the progesterone-dominant secretory phase is minimal in women with endometriosis, and exposure of endometrial cells to TCDD similarly disrupts cannabinoid signaling.

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Subtle progesterone rise on the day of hCG administration is associated with lower live birth rates in women undergoing assisted reproductive technology: a retrospective study with 2,555 fresh embryo transfers

Friday, June 8, 2012
In this retrospective, observational, cohort study with 2,555 women, a rise of serum P levels on the day of hCG administration was associated with a reduced live birth rate after day-5 fresh ET.

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Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles

Wednesday, May 30, 2012
Elevated serum P levels are associated with reduced ongoing pregnancy rates regardless of different ovarian responses. Increased P threshold concentration is associated with better ovarian responses.

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Vaginal (Crinone 8%) gel vs. intramuscular progesterone in oil for luteal phase support in in vitro fertilization: a large prospective trial

Friday, May 25, 2012
In younger patients undergoing IVF, luteal phase support with vaginal P produces significantly higher pregnancy rates than does IMP. Vaginal P is equally effective as IM in older patients.

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