Every last baby out of every last egg The appropriate goal for fertility treatment in women older than 40 years

Wednesday, June 1, 2016

Authors:
Richard J. Paulson, M.D.…

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Effects of maternal age on euploidy in a large cohort of embryos analyzed with 24 chromosome single nucleotide polymorphism based preimplantation genetic screening

Sunday, May 1, 2016
For 37,711 embryos analyzed with 24-chromosome single-nucleotide polymorphism–based preimplantation genetic screening, the number, proportion, and probability of embryos testing as euploid per IVF cycle were stratified by maternal age.

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The challenge of embryonic mosaicism in preimplantation genetic screening

Sunday, May 1, 2016

Authors:
Richard T. Scott Jr., M.D., Daniela Galliano, M.D.…

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Preimplantation genetic testing Polar bodies blastomeres trophectoderm cells or blastocoelic fluid

Tuesday, March 1, 2016
The chromosome condition of DNA retrieved by blastocentesis was highly concordant with that found in trophectoderm cells, polar bodies, and blastomeres. Segmental abnormalities could also be detected in blastocoelic fluids.

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Effectiveness of in vitro fertilization with preimplantation genetic screening A reanalysis of United States assisted reproductive technology data 2011 2012

Monday, February 15, 2016

Authors:
Vitaly A. Kushnir, M.D., Sarah K.…

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Comprehensive chromosome screening improves embryo selection A meta analysis

Monday, November 30, 2015
In patients with normal ovarian reserve, comprehensive chromosome screening increases clinical and sustained implantation rates, thus improving embryo selection.

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Embryo selection versus natural selection How do outcomes of comprehensive chromosome screening of blastocysts compare with the analysis of products of conception from early pregnancy loss dilation and curettage among an assisted reproductive technology population

Monday, November 30, 2015
This study compares the incidence of numerical chromosomal abnormalities reported after preimplantation genetic screening analysis vs. those reported after cytogenetic analysis of products of conception after spontaneous abortion.

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Endometrial pattern but not endometrial thickness affects implantation rates in euploid embryo transfers

Tuesday, September 1, 2015
Endometrial pattern, but not thickness, on trigger day affected a patient’s chance of achieving a pregnancy. The pattern or thickness at embryo transfer had no effect.

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Blastocoel fluid from differentiated blastocysts harbors embryonic genomic material capable of a whole genome deoxyribonucleic acid amplification and comprehensive chromosome microarray analysis

Thursday, July 30, 2015
A molecular karyotype can be obtained from genomic deoxyribonucleic acid isolated from the blastocoel fluid, which may provide insight into embryonic development and demonstrate the potential for future less invasive preimplantation genetic testing.

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Cost effectiveness analysis of preimplantation genetic screening and in vitro fertilization versus expectant management in patients with unexplained recurrent pregnancy loss

Wednesday, April 29, 2015
In vitro fertilization/preimplantation genetic screening is not cost effective in achieving live birth compared with expectant management in patients with unexplained recurrent pregnancy loss.

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Blastocentesis A source of DNA for preimplantation genetic testing Results from a pilot study

Tuesday, November 25, 2014
DNA retrieved by blastocentesis provided a chromosome condition that was highly correspondent with that found in trophectoderm cells. Results from polar bodies and blastomeres were also predictive of the blastocyst’s ploidy.

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Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors

Wednesday, July 30, 2014
Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst stage with a linear decrease in probability of blastulation with increasing number of chromosomal abnormalities.

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Blastocyst euploidy and implantation rates in a young <35 years and old ≥35 years presumed fertile and infertile patient population

Thursday, July 10, 2014
Our data demonstrated no difference in euploid blastocyst rates between presumed fertile and infertile patients. Pregnancy and implantation rates were significantly higher in presumed fertile patients when transferring euploid blastocysts.

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The practice of in vitro fertilization according to the published literature

Thursday, June 12, 2014
The “holy grail” of in vitro fertilization is identifying a single embryo that produces a healthy baby.

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Next generation sequencing The dawn of a new era for preimplantation genetic diagnostics

Wednesday, April 30, 2014
Reflections on "Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos" by Fiorentino et al.

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Development and validation of a next generation sequencing based protocol for 24 chromosome aneuploidy screening of embryos

Wednesday, April 30, 2014
Study reporting extensive preclinical validation and accuracy assessment of next-generation sequencing (NGS)-based comprehensive aneuploidy screening on single cells. NGS has demonstrated a robust methodology, ready for clinical application in reproductive medicine.

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The nature of aneuploidy with increasing age of the female partner a review of 15169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening

Thursday, February 20, 2014
The lowest aneuploidy risk is between ages 26–30, with higher prevalences inyoungerandolderwomen, and 67% involve a single chromosome,with the ratio of trisomies/monosomies approximating 1.

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Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization

Wednesday, November 27, 2013
Here we describe biopsy and chromosome screening with the use of array comparative genomic hybridization with biopsy at day 3 or day 5/6 of embryo development. The main outcome markers were implantation rate, ongoing pregnancy rate, and pregnancy loss rate.

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Comprehensive chromosome screening alters traditional morphology based embryo selection a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer

Friday, August 30, 2013
A prospective series of 100 consecutive cycles using CCS demonstrated that the blastocyst selected by day 5 morphology has a substantial risk of aneuploidy.

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24 chromosome copy number analysis a comparison of available technologies

Friday, August 30, 2013
The different technologies available for 24-chromosome copy number analysis at the single-cell level for preimplantation genetic screening are compared.

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Introduction Preimplantation genetic screening is alive and very well

Friday, August 30, 2013
Aneuploidy screening of all chromosomes (preimplantation genetic screening) at each stage of embryo development, the techniques available, and the advantages and disadvantages of each technique are reviewed.

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Selecting the optimal time to perform biopsy for preimplantation genetic testing

Friday, August 30, 2013
Contemporary biopsy for preimplantation genetic testing is most safely and effectively accomplished via trophectoderm biopsy at the blastocyst stage.

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In vitro fertilization with single euploid blastocyst transfer a randomized controlled trial

Friday, June 28, 2013
The Blastocyst Euploid Selective Transfer (BEST) Trial demonstrated that single euploid blastocyst transfer results in ongoing pregnancy rates that are equivalent to transferring two untested blastocysts, while dramatically reducing the risk of multiple gestations.

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One swallow does not make a summer

Thursday, March 28, 2013
Reflections on "Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials" by Rubio et al.

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The Effect of Timing of Embryonic Progression on Chromosomal Abnormality

Thursday, September 27, 2012
In this study analyzing embryo morphology and chromosomal status in relation to rate of embryonic developmental progression, the ability to blastulate, rather than day of blastulation, was found to significantly affect aneuploidy.

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Chromosomal abnormalities in embryos from couples with a previous aneuploid miscarriage

Tuesday, June 12, 2012
In preimplantation embryos, the incidence of chromosomal abnormalities due to a previous aneuploid miscarriage is significantly higher than in the control group of fertile couples who underwent preimplantation genetic screening for sex-linked diseases.

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Idiopathic Recurrent Miscarriage is Caused Mostly by Aneuploid Embryos

Friday, June 8, 2012
Current preimplantation screening results with array comparative genomic hybridization indicatea significant decrease in the miscarriage rate of idiopathic recurrent pregnancy loss patients. Furthermore, this confirms that idiopathic recurrent miscarriage is mostly caused by chromosomal abnormalities in embryos.

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