Searching for a common mechanism for placenta-mediated pregnancy complications and cardiovascular disease Role of lipoprotein a

Sunday, May 1, 2016
This study shows an association between lipoprotein(a) concentrations and history of stillbirth and preeclampsia. This well known atherothrombotic marker might represent one of the mechanisms shared by obstetrical and cardiovascular disease.

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Toward a better understanding of the oocyte donation preeclampsia connection

Wednesday, April 13, 2016

Authors:
Frederick Licciardi, M.D.…

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Increased incidence of gestational hypertension and preeclampsia after assisted reproductive technology treatment

Friday, April 1, 2016
After assisted reproductive technology (ART), mothers had a 17% increased likelihood of gestational hypertension and preeclampsia compared with non-ART mothers, which was likely associated with the ART mothers’ multiple pregnancies.

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Hypertensive pathologies and egg donation pregnancies Results of a large comparative cohort study

Friday, March 11, 2016

Authors:
Hélène Letur, M.D., Maëliss Peigné, M.D., Jeanine Ohl, M.D., Isabelle Cédrin-Durnerin, M.D., Emmanuelle Mathieu-D’Argent, M.D., Florence Scheffler, M.D., Veronika Grzegorczyk-Martin, M.D., Jacques de Mouzon, M.D., M.P.H.…

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Fetal Val108 158Met catechol O methyltransferase COMT polymorphism and placental COMT activity are associated with the development of preeclampsia

Tuesday, December 29, 2015
Fetal Met-Met genotype of Val158Met determines catechol-O-metyltransferase placental expression and activity in vitro and increases preeclampsia risk. However, decreased levels of 2-methoxyestradiol present in preeclampsia do not depend exclusively on this polymorphism.

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Involvement of estrogen related receptor γ and mitochondrial content in intrauterine growth restriction and preeclampsia

Thursday, July 30, 2015
Estrogen-related receptor-g expression and mitochondrial content were markedly lower in IUGR placentas as compared with control placentas. This finding suggests that estrogen-related receptor-g is involved in the control of placental development.

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Preeclampsia is associated with a deficiency of lipoxin A4 An endogenous anti inflammatory mediator

Wednesday, June 25, 2014
Lipoxin A4 deficiency may result in preeclampsia because of changes in inflammation, oxidative stress, and 11b-HSD2 expression.

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Perinatal outcomes in 375 children born after oocyte donation a Danish national cohort study

Tuesday, April 30, 2013
Children born after oocyte donation have a higher risk of preterm birth and low birth weight than after standard in vitro fertilization, mainly due to the risk of preeclampsia.

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The role and challenges of biomarkers in spontaneous preterm birth and preeclampsia

Monday, March 18, 2013
Despite the promise of biologically plausible biomarkers to identify patients at increased risk for spontaneous preterm birth and/or preeclampsia, the use of biomarkers in clinical practice to predict adverse obstetrical outcome remains challenging.

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Idiopathic liver function test abnormality in pregnancy is associated with assisted reproduction techniques

Monday, February 4, 2013
This retrospective study analyzed the risk factors for development of significant liver dysfunction in pregnancy and it's specific etiologies. Assisted reproduction was significantly associated with liver test abnormalities.

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Cell derived microparticles and vascular pregnancy complications A systematic and comprehensive review

Monday, February 4, 2013
Pregnancy showed a cMP increase. Differences in numbering and types of cMP in normal pregnancy, RM and PE have been demonstrated. Endothelial-derived cMP are increased in patients with antiphospholipid antibodies.

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Elective cryopreservation of all embryos with subsequent cryothaw embryo transfer in patients at risk for ovarian hyperstimulation syndrome reduces the risk of adverse obstetric outcomes A preliminary study

Wednesday, January 2, 2013
Interval transfer of cryopreserved embryos derived from prior in vitro fertilization stimulation with elevated peak estradiol level reduces the risk of adverse obstetric outcomes.

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Thrombin enhances soluble fms-like tyrosine kinase-1 expression in trophoblasts Possible involvement in the pathogenesis of preeclampsia

Thursday, September 27, 2012
Thrombin enhances the secretion of sFlt-1 from trophoblasts, indicating that increased thrombin in the uteroplacental interface may contribute to the pathogenesis of preeclampsia.

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Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization

Wednesday, May 30, 2012
Elevated serum estradiol level on the day of human chorionic gonadotropin administration is associated with adverse obstetrical outcomes.

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