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Tuesday, September 29, 2015
Bradley S. Hurst, M.D.…
Shifting anaerobic to aerobic metabolism stimulates apoptosis through modulation of redox balance Potential intervention in the pathogenesis of postoperative adhesions
Tuesday, September 29, 2015Dichloroacetate modulates redox homeostasis, thus protecting cells against anaerobic metabolism and associated oxidative stress. This may provide targets for therapeutic intervention for treatment of profibrotic disorders, including postoperative adhesions.
Uncoupling oxidative phosphorylation with 2,4-dinitrophenol promotes development of the adhesion phenotype
Wednesday, May 23, 2012The adhesion phenotype, which is normally expressed in response to hypoxia, is reproduced in a normoxic environment by uncoupling oxidative phosphorylation with 2,4-dinitrophenol.
Friday, May 4, 2012Gene microarray analysis allows comparison of gene expression of adhesion and normal peritoneal tissues. We identified several specific genes with functions relevant to the pathogenesis of postoperative adhesions.
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AMH aneuploidy antimüllerian hormone antral follicle count apoptosis ART assisted reproduction Assisted reproductive technology azoospermia Blastocyst cancer cryopreservation ectopic pregnancy embryo embryo transfer Endometriosis endometrium ethics fertility fertility preservation GnRH antagonist ICSI implantation infertility insulin resistance intracytoplasmic sperm injection in vitro fertilization IVF live birth male infertility miscarriage obesity oocyte ovarian reserve ovarian stimulation oxidative stress PCOS Polycystic ovary syndrome pregnancy Preimplantation genetic screening progesterone Recurrent pregnancy loss sperm spermatogenesis vitrification