Adhesion phenotype manifests an altered metabolic profile favoring glycolysis

Wednesday, June 1, 2016
Adhesion fibroblasts manifested an altered metabolic profile as compared with normal peritoneal fibroblasts, which favors the glycolytic pathway, and is further altered by hypoxia.

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Exploring adhesion formation and prevention

Tuesday, September 29, 2015

Authors:
Bradley S. Hurst, M.D.…

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Shifting anaerobic to aerobic metabolism stimulates apoptosis through modulation of redox balance Potential intervention in the pathogenesis of postoperative adhesions

Tuesday, September 29, 2015
Dichloroacetate modulates redox homeostasis, thus protecting cells against anaerobic metabolism and associated oxidative stress. This may provide targets for therapeutic intervention for treatment of profibrotic disorders, including postoperative adhesions.

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Uncoupling oxidative phosphorylation with 2,4-dinitrophenol promotes development of the adhesion phenotype

Wednesday, May 23, 2012
The adhesion phenotype, which is normally expressed in response to hypoxia, is reproduced in a normoxic environment by uncoupling oxidative phosphorylation with 2,4-dinitrophenol.

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Microarray expression profiling in adhesion and normal peritoneal tissues

Friday, May 4, 2012
Gene microarray analysis allows comparison of gene expression of adhesion and normal peritoneal tissues. We identified several specific genes with functions relevant to the pathogenesis of postoperative adhesions.

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