Evolutionary determinants of polycystic ovary syndrome Part 1

Monday, May 16, 2016

Authors:
Uğur Ünlütürk, M.D., Efe Sezgin, Ph.D., Bulent Okan Yildiz, M.D.…

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Environmental determinants of polycystic ovary syndrome

Monday, May 16, 2016

Authors:
Sharon Stein Merkin, Ph.D., M.H.S., Jennifer L.…

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Introduction The determinants of PCOS

Thursday, May 12, 2016

Author:
Ricardo Azziz, M.D., M.P.H.…

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Higher PDCD4 expression is associated with obesity insulin resistance lipid metabolism disorders and granulosa cell apoptosis in polycystic ovary syndrome

Sunday, May 1, 2016
In polycystic ovary syndrome (PCOS), higher PDCD4 expression promotes obesity, insulin resistance, lipid metabolism disorders, and induced granulosa cell apoptosis, which is an independent risk factor for PCOS.

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Increased antimullerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome

Tuesday, March 15, 2016

Authors:
Laura C. Torchen, M.D., Ajay Kumar, Ph.D., Bhanu Kalra, Ph.D., Gopal Savjani, B.S., Ryan Sisk, B.S., Richard S.…

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Pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization

Tuesday, March 1, 2016
The authors identify PCOS as an independent risk factor for the development of specific pregnancy complications in singleton pregnancies after IVF with or without intracytoplasmic sperm injection.

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Assessing new terminal body and facial hair growth during pregnancy Toward developing a simplified visual scoring system for hirsutism

Monday, February 1, 2016
We discuss the distribution and progression of terminal hair growth in pregnant women and determine the feasibility of a simplified scoring system for assessing hirsutism.

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Vigorous exercise is associated with superior metabolic profiles in polycystic ovary syndrome independent of total exercise expenditure

Monday, February 1, 2016
Vigorous exercise is associated with superior health profiles and reduced odds of metabolic syndrome in polycystic ovary syndrome, independent of age, body mass index, or total exercise expenditure.

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Clinical utility of magnetic resonance imaging and ultrasonography for diagnosis of polycystic ovary syndrome in adolescent girls

Thursday, October 29, 2015
The current study suggests that MRI for determination of ovarian ultrastructure morphology in adolescent girls with PCOS may provide more information when compared with US.

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Putative role for insulin resistance in depression risk in polycystic ovary syndrome

Tuesday, September 1, 2015
Insulin resistance was found to be linked to depression risk, after controlling for potential confounders, in women who have polycystic ovary syndrome.

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Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome Summary of a Cochrane review

Tuesday, September 1, 2015
We conducted a systematic review of the use of metformin as a cotreatment during in vitro fertilization and during intracytoplasmic sperm injection in women with polycystic ovary syndrome.

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Android fat distribution affects some hemostatic parameters in women with polycystic ovary syndrome compared with healthy control subjects matched for age and body mass index

Thursday, July 30, 2015
Android fat distribution, older age, insulin resistance, and free testosterone levels may affect some hemostatic parameters in polycystic ovary syndrome, particularly in young and overweight women.

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Validity of adiponectin to leptin and adiponectin to resistin ratios as predictors of polycystic ovary syndrome

Thursday, July 30, 2015
The ratios of adiponectin/leptin and adiponectin/resistin constitute novel predictor factors used to explain polycystic ovary syndrome and associated features.

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Genome wide screen of ovary specific DNA methylation in polycystic ovary syndrome

Monday, June 29, 2015
Methylation patterns in tissue from polycystic ovary syndrome were distinguishable from control samples and were associated with promoter class, genomic location, and specific biological networks.

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Antimullerian hormone levels decrease in female to male transsexual women using testosterone as cross sex therapy

Wednesday, April 29, 2015
Polycystic ovary syndrome is associated with elevated antimullerian hormone (AMH) levels. In this study, AMH serum levels significantly decreased after androgenic treatment in female-to-male transsexual subjects.

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Antioxidant properties of high density lipoproteins are impaired in women with polycystic ovary syndrome

Wednesday, April 29, 2015
The antioxidant/anti-inflammatory function of HDL was impaired in PCOS. High-density lipoprotein dysfunction is related to hyperandrogenism status, increased oxidative stress, and abnormalities in HDL components.

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Ultrasound features of polycystic ovaries relate to degree of reproductive and metabolic disturbance in polycystic ovary syndrome

Friday, February 27, 2015
Associations between ultrasound features and reproductive and metabolic markers in women with polycystic ovary syndrome (PCOS) were assessed. Follicle populations reflected the severity of reproductive and metabolic dysfunction in PCOS.

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Aromatase inhibitors for subfertile women with polycystic ovary syndrome Summary of a Cochrane review

Friday, January 30, 2015
Letrozole appears to be superior to clomiphene citrate for ovulation induction in subfertile women with polycystic ovary syndrome.

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Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes Who is really at risk

Friday, August 1, 2014
Women with hyperandrogenic polycystic ovary syndrome (PCOS) show a more unfavorable cardiometabolic profile compared with women with nonhyperandrogenic PCOS. However, screening for cardiovascular risk factors is crucial in all women with PCOS.

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Study of circulating hepcidin in association with iron excess metabolic syndrome and BMP6 expression in granulosa cells in women with polycystic ovary syndrome

Wednesday, July 30, 2014
Serum hepcidin levels are increased in polycystic ovary syndrome women and correlated with iron excess and metabolic disorder, but not with BMP-6 expression in granulosa cells.

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Utility of ultrasound in the diagnosis of polycystic ovary syndrome in adolescents

Tuesday, July 22, 2014
Polycystic ovary morphology according to the modified Rotterdam criteria in a nongynecologic cohort in our study is less common than previously reported. Transabdominal ultrasound may be a useful tool in the evaluation of polycystic ovary syndrome, even in obese adolescents.

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Genome wide identification of aberrantly methylated promoters in ovarian tissue of prenatally androgenized rats

Thursday, July 10, 2014
Prenatally androgenized rats had aberrant metabolic and polycystic ovary morphology similar to human polycystic ovary syndrome (PCOS). Changesof DNA methylation may be an important factor for epigenetic programming of PCOS during development.

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Assessment of insulin resistance in lean women with polycystic ovary syndrome

Wednesday, June 25, 2014
In primary prevention practice, HOMA-M120 and Sib (Avignon et al.) seem to adequately replace the euglycemic-hyperinsulinemic clamp in lean and overweight/obese PCOS patients, respectively.

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Association of abdominal obesity insulin resistance and oxidative stress in adipose tissue in women with polycystic ovary syndrome

Tuesday, June 17, 2014
The strong correlation of insulin resistance and oxidative stress at the visceral adipose tissue level suggests that local oxidative stress and abnormalities of insulin signaling in the adipose tissue play critical roles in polycystic ovary syndrome insulin resistance.

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Metabolic profile of the different phenotypes of polycystic ovary syndrome in two Latin American populations

Sunday, June 1, 2014
The phenotype distribution and metabolic characteristics of polycystic ovary syndrome differ in Chile and Argentina; the former is more metabolically altered and the latter more hypertensive.

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High dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome A randomized controlled pilot trial

Sunday, June 1, 2014
In a randomized, placebo-controlled trial of vitamin D in PCOS, insulin sensitivity was unchanged, but there was a trend toward decreased 2-hour insulin and a protective effect on blood pressure.

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Influence of oral contraceptives on anthropomorphometric endocrine and metabolic profiles of anovulatory polycystic ovary syndrome patients

Sunday, June 1, 2014
Oral contraceptive pill use is associated with a higher risk of future endometriosis diagnosis in nulliparous women but a lower risk among parous women.

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Family based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome

Wednesday, April 30, 2014
Transmission disequilibrium test analysis confirms that single-nucleotide polymorphism rs1501299 in ADIPOQ is significantly associated with risk of polycystic ovary syndrome in the Chinese population.

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Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome

Wednesday, April 30, 2014
Our well-defined cohort provided comprehensive estimates of the features of metabolic and phenotypic profiles related to polycystic ovary syndrome in Korean women.

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Gonadal dysfunction in morbidly obese adolescent girls

Monday, March 31, 2014
Twenty-five percent of morbidly obese girls were affected with PCOS, and 33% had metabolic syndrome; PCOS and its individual components did not predict metabolic syndrome in morbidly obese adolescents.

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