Every last baby out of every last egg The appropriate goal for fertility treatment in women older than 40 years

Wednesday, June 1, 2016

Authors:
Richard J. Paulson, M.D.…

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Mosaicism Survival of the fittest versus no embryo left behind

Sunday, May 1, 2016

Authors:
Santiago Munné, Ph.D., James Grifo, M.D., Ph.D., Dagan Wells, Ph.D.…

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Lightening the burden of care in assisted reproductive technology

Sunday, May 1, 2016

Authors:
David Roy Meldrum, M.D.…

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Preimplantation genetic screening is an excellent tool but not perfect A guide to counseling patients considering PGS

Tuesday, December 29, 2015

Authors:
Paul R. Brezina, M.D., M.B.A., William H.…

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Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors

Wednesday, July 30, 2014
Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst stage with a linear decrease in probability of blastulation with increasing number of chromosomal abnormalities.

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Comprehensive chromosome screening with synchronous blastocyst transfer Time for a paradigm shift

Thursday, June 12, 2014
The validation of 24-chromosome testing platforms has led to a variety of studies demonstrating higher implantation and delivery rates.

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Next generation sequencing Challenges in reproductive genetics

Wednesday, April 30, 2014
Reflections on "Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos" by Yeh et al.

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Next generation sequencing The dawn of a new era for preimplantation genetic diagnostics

Wednesday, April 30, 2014
Reflections on "Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos" by Fiorentino et al.

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Introduction Preimplantation genetic screening is alive and very well

Friday, August 30, 2013
Aneuploidy screening of all chromosomes (preimplantation genetic screening) at each stage of embryo development, the techniques available, and the advantages and disadvantages of each technique are reviewed.

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Polar body biopsy

Friday, August 30, 2013
Polar body biopsy combined with array comparative genomic hybridization allows detection of maternal chromosomal aberrations. Although it has limitations, it can be seen as an alternative to blastomere and trophectoderm biopsy.

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Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age Two randomized trials

Thursday, March 28, 2013
Preimplantation genetic screening using fluorescence in situ hybridization improves live-birth rates in patients with repetitive implantation failure or advanced maternal age.

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Use of array comparative genomic hybridization array CGH for embryo assessment Clinical results

Monday, March 18, 2013
The use of array comparative genomic hybridization in preimplantation genetic screening produces high pregnancy rates with embryo biopsy at different stages.

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Morphologic abnormalities in 2 year old children born after in vitro fertilization intracytoplasmic sperm injection with preimplantation genetic screening Follow up of a randomized controlled…

Monday, February 4, 2013
In this follow-up study of a randomized controlled trial on preimplantation genetic screening (PGS), the percentage of 2-year-old children with one or more major abnormality in the group born after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) with PGS did not exceed the percentage in those born after IVF/ICSI without PGS.

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Detection of aneuploidy by array comparative genomic hybridization using cell lines to mimic a mosaic trophectoderm biopsy

Friday, May 11, 2012
Array comparative genomic hybridization analysis of mosaic samples can help determine the detectable level of aneuploidy. Aneuploidy could be confidently called when the level of aneuploid cells in the sample was >50%.

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Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes

Friday, May 11, 2012
High intra-age, intercycle, and intercenter variation in oocyte aneuploidy was observed in first polar body chromosome analysis of oocyctes.

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