Small glutamine rich tetratricopeptide repeat containing protein alpha is present in human ovaries but may not be differentially expressed in relation to polycystic ovary syndrome

Friday, May 31, 2013
Small glutamine-rich tetratricopeptide repeat–containing protein alpha is expressed in human ovarian tissues and has the potential to modulate androgen receptor signaling, but expression levels may not be abnormal in polycystic ovary syndrome.

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New approach in patients with polycystic ovaries lessons for everyone

Thursday, March 28, 2013
In vitro maturation, including FSH priming, recovery of oocytes from 12-mm follicles, and using single blastocyst transfer, is safe and provides pregnancy rates up to 40% in patients with PCO.

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In vitro maturation A committee opinion

Friday, March 1, 2013
In vitro maturation should be performed only as an experimental procedure for carefully selected patients evaluating both efficacy and safety.

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Altered insulin induced relaxation of aortic rings in a dihydrotestosterone induced rodent model of polycystic ovary syndrome

Monday, February 4, 2013
Insulin-dependent vasorelaxation in aortic rings in a PCOS rat model is decreased (both NO-dependent or independent), and vitamin D treatment can improve only the NO-independent model.

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The levels of hepatocyte growth factor in serum and follicular fluid and the expression of c Met in granulosa cells in patients with polycystic ovary syndrome

Wednesday, January 2, 2013
The levels of follicular fluid and serum hepatocyte growth factor (HGF) and the expression of c-Met in polycystic ovary syndrome were determined along with the importance of HGF/c-Met signaling in fertilization success.

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Predicting fertility with antimullerian hormone Is a cutoff value adequate

Thursday, November 29, 2012
Reflections on "Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study" by Hagen et al.

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Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women A prospective cohort study

Thursday, November 29, 2012
Low AMH levels in young healthy women did not predict reduced fecundability. Even after exclusion of women with irregular cycles, the probability of conceiving was reduced in women with high AMH levels.

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Does the level of serum antimullerian hormone predict ovulatory function in women with Polycystic Ovary Syndrome with aging

Thursday, September 27, 2012
Anovulatory women with polycystic ovary syndrome (PCOS) and matched control subjects were followed for 5 years. Women with PCOS who had normal menses after 5 years had significantly lower initial serum antimullerian hormone levels.

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Limitations and pitfalls of antimüllerian hormone measurements

Thursday, September 27, 2012
Reflections on "High frequency of discordance between antimullerian hormone and follicle-stimulating hormone levels in serum from estradiol-confirmed days 2 to 4 of the menstrual cycle from 5,354 women in U.S. fertility centers"

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Comparative study of the therapeutic effects of oral contraceptive pills containing desogestrel cyproterone acetate and drospirenone in patients with polycystic ovary syndrome

Thursday, September 27, 2012
Therapeutic effects of three different oral contraceptive pills are comparable after 6 months of treatment. After 12 months, the cyproterone containing pill shows greater antiandrogenic effect. Effects on metabolic parameters are identical.

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Metformin: Direct Inhibition of Rat Ovarian Theca-Interstitial Cell Proliferation

Tuesday, June 12, 2012
Metformin activates adenosine monophosphate–activated protein kinase (AMPK) in rat ovarian thecainterstitial cells and subsequently inhibits cell proliferation and insulin-induced mitogenic signaling pathways.

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Does ovulation induction with follicle-stimulating hormone still have a future in polycystic ovary syndrome?

Friday, June 8, 2012

Author:
Robert John Norman, M.D.…

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Adipose expression of adipocytokines in women with polycystic ovary syndrome

Thursday, June 7, 2012
In a cross-sectional study of women with and without polycystic ovary syndrome (PCOS), obesity but not PCOS affected the expression of adipose expression and plasma levels of adipocytokines.

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Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis

Monday, June 4, 2012
Women with polycystic ovary syndrome have six-fold greater odds of generalized anxiety symptoms compared with control women, suggesting the need to routinely screen for anxiety symptoms.

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Should all women with PCOS be treated for insulin resistance?

Thursday, May 31, 2012
Insulin resistance of variable severity is commonly present in women with PCOS. Arguments and rationale are presented for treating all or only selected women with insulin sensitizing drugs.

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Is PCOS an inflammatory process?

Thursday, May 31, 2012
While the etiology of PCOS remains a mystery, the evidence in support of the presence of chronic lowgrade inflammation in women with this syndrome is emerging.

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Does PCOS have developmental origins?

Thursday, May 31, 2012
The pros and cons of the proposition that PCOS has developmental origins are laid out based on the best available evidence.

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PCOS: key issues and remaining questions

Thursday, May 31, 2012
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women and yet remains enigmatic.

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Androgens and antimüllerian hormone in mothers with polycystic ovary syndrome and their newborns

Thursday, May 31, 2012
In mothers with polycystic ovary syndrome, metformin had no impact on antim€ullerian hormone or androgen levels but increased the free testosterone index in the umbilical vein of boys.

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Arteriolar insulin resistance in a rat model of polycystic ovary syndrome

Thursday, May 31, 2012
In dihydrotestosterone-treated female rats, decrease of insulin-induced relaxation of arterioles was observed in addition to metabolically proven insulin resistance; both were improved by parallel vitamin D treatment.

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Developmental programming: prenatal testosterone excess disrupts anti-Müllerian hormone expression in preantral and antral follicles

Thursday, May 24, 2012
Prenatal T leads to changes in anti-Mullerian hormone protein expression that likely accounts for the increased follicular recruitment and persistence found in this animal model of PCOS.

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The impairment of reproduction in db/db mice is not mediated by intraovarian defective leptin signaling

Friday, May 4, 2012
We report on how impairment of reproduction in db mice is not mediated by intraovary intact/defective leptin signaling even in the face of a significantly divergent modulation by gonadotropins.

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