Distinguishing characteristics of metabolically healthy versus metabolically unhealthy obese adolescent girls with polycystic ovary syndrome

Wednesday, June 1, 2016
Among obese girls with polycystic ovary syndrome, 27% who are metabolically healthy have a more favorable risk profile for type 2 diabetes, atherogenesis, inflammation, and androgenemia compared with the 73% who are metabolically unhealthy.

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Evolutionary determinants of polycystic ovary syndrome Part 2

Thursday, May 19, 2016

Authors:
Daniel M.T. Fessler, Ph.D., Barbara Natterson-Horowitz, M.D., Ricardo Azziz, M.D.…

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Environmental determinants of polycystic ovary syndrome

Monday, May 16, 2016

Authors:
Sharon Stein Merkin, Ph.D., M.H.S., Jennifer L.…

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Introduction The determinants of PCOS

Thursday, May 12, 2016

Author:
Ricardo Azziz, M.D., M.P.H.…

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Working memory in women with polycystic ovary syndrome

Sunday, May 1, 2016

Author:
Courtney A. Marsh, M.D., M.P.H.…

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Does polycystic ovarian syndrome affect cognition A functional magnetic resonance imaging study exploring working memory

Sunday, May 1, 2016
Antiandrogenic treatment appears to have a beneficial effect on working memory in women with polycystic ovary syndrome.

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Cardiovascular disease risk in first degree relatives of women with polycystic ovary syndrome

Sunday, May 1, 2016
Increased risk of cardiovascular disease in parents of polycystic ovary syndrome as evidenced by increased carotid intima media thickness and low brachial artery flow-mediated dilatation as compared with matched controls.

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An update on the genetics of polycystic ovary syndrome Progress and future directions

Tuesday, April 26, 2016

Authors:
Michelle R. Jones, Ph.D., Mark O.…

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Comparative assessment of five serum antimullerian hormone assays for the diagnosis of polycystic ovarian syndrome

Friday, April 1, 2016
The performance of the different commercial antimullerian hormone assays for polycystic ovary syndrome diagnosis is comparable, but different threshold values should be used for automatic and manual assays.

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Association study of androgen signaling pathway genes in polycystic ovary syndrome

Monday, February 1, 2016
Single-nucleotide polymorphisms in the FKBP4 gene,which codes for a co-chaperone of the androgen receptor, may be associated with polycystic ovary syndrome and body mass index.

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Oral glucose tolerance test significantly impacts the prevalence of abnormal glucose tolerance among Indian women with polycystic ovary syndrome Lessons from a large database of two tertiary care centers on the Indian subcontinent

Tuesday, December 29, 2015
Indian women with polycystic ovary syndrome (PCOS) have a high prevalence of abnormal glucose tolerance, and oral glucose tolerance test significantly impacts its prevalence. Data are from a large cohort of women with PCOS attending two tertiary care centers in north India.

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Ovarian volume in normal and hyperandrogenic adolescent women

Monday, June 29, 2015
After the first 2 years from menarche, the threshold for increased ovarian size is similar to that reported in adult women.

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PON1 polymorphisms are associated with polycystic ovary syndrome susceptibility related traits and PON1 activity in Indian women with the syndrome

Monday, June 29, 2015

Authors:
Roshan Dadachanji, M.Sc., Nuzhat Shaikh, M.Sc., Sushma Khavale, B.Sc., Anushree Patil, M.D., Nalini Shah, M.D., Srabani Mukherjee, Ph.D.…

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Unraveling the fertility knot in World Health Organization type 2 anovulatory women Another step toward a pharmacogenetic treatment choice

Monday, March 30, 2015
Reflections on "FSH receptor polymorphism affects the outcome of ovulation induction in normogonadotropic (WHO2) anovulatory infertility" by Valkenburg et al.

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Off label drug use in the treatment of polycystic ovary syndrome

Friday, February 27, 2015
This review explores the off-label use of medications used to manage aspects of polycystic ovary syndrome, including androgen excess, irregular menses, and metabolic changes.

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Insulin resistance and hyperandrogenism have no substantive association with birth weight in adolescents with polycystic ovary syndrome

Friday, February 27, 2015
Low birth weight may influence the appearance of hyperandrogenism and insulin resistance in some adolescents with polycystic ovary syndrome, but in the majority factors other than birth weight are implicated.

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Use of gonadotropin releasing hormone agonist trigger during in vitro fertilization is associated with similar endocrine profiles and oocyte measures in women with and without polycystic ovary syndrome

Monday, December 29, 2014
Use of a gonadotropin-releasing hormone agonist trigger during in vitro fertilization results in similar hormone profiles, mature oocyte yield, and pregnancy outcomes in women with polycystic ovarian syndrome when compared with other high responders.

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Leptin downregulates γENaC expression A novel mechanism involved in low endometrial receptivity

Monday, December 29, 2014
Polycystic ovary syndrome patients who are overweight or obese showed increased serum leptin levels. High leptin levels may reduce g-epithelial Naþ channel expression in human endometrium via activating the STAT3 pathway, resulting in attenuated endometrial receptivity.

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Role of vitamin D in ovarian physiology and its implication in reproduction A systematic review

Wednesday, July 30, 2014
Vitamin D plays an important role in steroidogenesis, follicular development, ovarian reserve measures/markers, and IVF outcome. Vitamin D might have a beneficial reproductive effect in vitamin D–deficient women with polycystic ovary syndrome.

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Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes

Wednesday, July 30, 2014
The ability of murine ovarian hormone synthesis became abnormal and the ovarian tissue behaved insulin resistance, after treated with dexamethasone, in vivo and in vitro; the Chinese herbal extract cryptotanshinone was found to partially antagonize their behavior.

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Age specific serum antimüllerian hormone levels in women with and without polycystic ovary syndrome

Wednesday, June 25, 2014
Age-specific antimullerian hormone (AMH) references were determined in women with and without polycystic ovary syndrome (PCOS). AMH levels were higher in women with PCOS than in those without PCOS. AMH correlated well with age and antral follicle count.

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Regulatory role of microRNAs in ovarian function

Sunday, June 1, 2014
MicroRNAs have a fundamental role in the regulation of gene expression in the ovary. Research on the role in physiological and dysfunctional ovulation may offer new diagnostic and therapeutic strategies.

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Ovarian morphology assessed by magnetic resonance imaging in women with and without polycystic ovary syndrome and associations to anti Müllerian hormone free testosterone and glucose disposal rate

Sunday, June 1, 2014
Magnetic resonance imaging yielded higher antral follicle counts (AFC) than previously reported. AFC, antimullerian hormone, and free testosterone discriminated with high accuracy between women with polycystic ovary syndrome and controls.

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Insulin resistance and its relationship with high molecule weight adiponectin in adolescents with polycystic ovary syndrome and a maternal history

Tuesday, May 20, 2014
Normal weight adolescents with PCOS and a maternal history of PCOS had a significantly increased rate of insulin resistance independent of body mass index and inversely correlated with high molecular weight adiponectin.

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Cluster analysis of cardiovascular and metabolic risk factors in women of reproductive age

Wednesday, April 30, 2014
Although polycystic ovary syndrome is associated with metabolic risk, obesity was the major determinant for cardiometabolic disturbances in reproductive-aged women.

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Black women with polycystic ovary syndrome have increased risk for metabolic syndrome and cardiovascular disease compared with white women without PCOS

Friday, January 31, 2014
Black adolescents and adult women with PCOS have an increased risk of metabolic syndrome compared with their white counterparts. These findings differ from population-based controls and are independent of obesity in adults.

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A freeze all embryo strategy after in vitro maturation a novel approach in women with polycystic ovary syndrome

Monday, September 30, 2013
In vitro maturation (IVM) of oocytes followed by a “freeze-all” embryo strategy results in promising clinical outcomes in patients with polycystic ovary syndrome and circumvents the potential problem of suboptimal endometrial quality in IVM cycles.

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Serum antimüllerian hormone in response to dietary management and or physical exercise in overweight obese women with polycystic ovary syndrome secondary analysis of a randomized controlled trial

Monday, September 30, 2013
Randomized intervention with diet, but not exercise or combined intervention, reduces serum AMH levels in association with decreased T in obese women with PCOS, whereas weight loss has no significant influence.

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Transforming growth factor β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation

Wednesday, July 31, 2013
Increased transforming growth factor-b1 and decreased levels of its receptor, soluble endoglin are found in women with polycystic ovarian syndrome (PCOS) and may be implicated in PCOS pathogenesis and its increased risk for ovarian hyperstimulation.

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The Kiss1 system and polycystic ovary syndrome lessons from physiology and putative pathophysiologic implications

Friday, June 28, 2013
Potential implications of alterations of the Kiss1 system in the pathophysiology of polycystic ovary syndrome are discussed. The limited experimental and clinical evidence supporting such a role is summarized.

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