In vitro maturation, including FSH priming, recovery of oocytes from 12-mm follicles, and using single blastocyst transfer, is safe and provides pregnancy rates up to 40% in patients with PCO.
In vitro maturation should be performed only as an experimental procedure for carefully selected patients evaluating both efficacy and safety.
Insulin-dependent vasorelaxation in aortic rings in a PCOS rat model is decreased (both NO-dependent or independent), and vitamin D treatment can improve only the NO-independent model.
The levels of follicular fluid and serum hepatocyte growth factor (HGF) and the expression of c-Met in polycystic ovary syndrome were determined along with the importance of HGF/c-Met signaling in fertilization success.
Reflections on “Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study” by Hagen et al.
Low AMH levels in young healthy women did not predict reduced fecundability. Even after exclusion of women with irregular cycles, the probability of conceiving was reduced in women with high AMH levels.
Anovulatory women with polycystic ovary syndrome (PCOS) and matched control subjects were followed for 5 years. Women with PCOS who had normal menses after 5 years had significantly lower initial serum antimullerian hormone levels.
Reflections on “High frequency of discordance between antimullerian hormone and follicle-stimulating hormone levels in serum from estradiol-confirmed days 2 to 4 of the menstrual cycle from 5,354 women in U.S. fertility centers”
Therapeutic effects of three different oral contraceptive pills are comparable after 6 months of treatment. After 12 months, the cyproterone containing pill shows greater antiandrogenic effect. Effects on metabolic parameters are identical.
Metformin activates adenosine monophosphate–activated protein kinase (AMPK) in rat ovarian thecainterstitial cells and subsequently inhibits cell proliferation and insulin-induced mitogenic signaling pathways.
Author:
Robert John Norman, M.D.…
In a cross-sectional study of women with and without polycystic ovary syndrome (PCOS), obesity but not PCOS affected the expression of adipose expression and plasma levels of adipocytokines.
Women with polycystic ovary syndrome have six-fold greater odds of generalized anxiety symptoms compared with control women, suggesting the need to routinely screen for anxiety symptoms.
Insulin resistance of variable severity is commonly present in women with PCOS. Arguments and rationale are presented for treating all or only selected women with insulin sensitizing drugs.
While the etiology of PCOS remains a mystery, the evidence in support of the presence of chronic lowgrade inflammation in women with this syndrome is emerging.
The pros and cons of the proposition that PCOS has developmental origins are laid out based on the best available evidence.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women and yet remains enigmatic.
In mothers with polycystic ovary syndrome, metformin had no impact on antim€ullerian hormone or androgen levels but increased the free testosterone index in the umbilical vein of boys.
In dihydrotestosterone-treated female rats, decrease of insulin-induced relaxation of arterioles was observed in addition to metabolically proven insulin resistance; both were improved by parallel vitamin D treatment.
Prenatal T leads to changes in anti-Mullerian hormone protein expression that likely accounts for the increased follicular recruitment and persistence found in this animal model of PCOS.
We report on how impairment of reproduction in db mice is not mediated by intraovary intact/defective leptin signaling even in the face of a significantly divergent modulation by gonadotropins.
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