Exploring adhesion formation and prevention

Tuesday, September 29, 2015

Authors:
Bradley S. Hurst, M.D.…

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Shifting anaerobic to aerobic metabolism stimulates apoptosis through modulation of redox balance Potential intervention in the pathogenesis of postoperative adhesions

Tuesday, September 29, 2015
Dichloroacetate modulates redox homeostasis, thus protecting cells against anaerobic metabolism and associated oxidative stress. This may provide targets for therapeutic intervention for treatment of profibrotic disorders, including postoperative adhesions.

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Differences in the seminal plasma proteome are associated with oxidative stress levels in men with normal semen parameters

Thursday, July 30, 2015
Seminal plasma proteome reflects semen lipid peroxidation status, with the expression of proteins related to reactive oxygen species metabolism. These proteins may be used as biomarkers for semen oxidative stress.

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Randomized triple blind placebo controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men

Thursday, July 30, 2015
Three months of supplementation with alpha-lipoic acid improved sperm quality in infertile men. Medical therapy with oral antioxidants can improve quality of semen parameters.

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Antioxidant properties of high density lipoproteins are impaired in women with polycystic ovary syndrome

Wednesday, April 29, 2015
The antioxidant/anti-inflammatory function of HDL was impaired in PCOS. High-density lipoprotein dysfunction is related to hyperandrogenism status, increased oxidative stress, and abnormalities in HDL components.

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Oocyte environment Follicular fluid and cumulus cells are critical for oocyte health

Friday, January 30, 2015
Bidirectional somatic cell–oocyte interactions are essential to create a dynamic intrafollicular microenvironment that fosters development of a healthy oocyte and preimplantation embryo.

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Inflammatory biomarkers and telomere length in women with polycystic ovary syndrome

Friday, January 30, 2015
Leukocyte telomere length (LTL) did not differ between PCOS and control groups; however, C-reactive protein and homocysteine were negatively correlated with LTL in the PCOS group.

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Reactive oxygen species in human semen Validation and qualification of a chemiluminescence assay

Tuesday, November 25, 2014
Reactive oxygen species can be measured accurately and reliably with the use of a simple luminol- based chemiluminescence assay. This test can be incorporated into routine testing of human semen for male infertility.

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Upregulation of heme oxygenase 1 expression modulates reactive oxygen species level during the cryopreservation of human seminiferous tubules

Wednesday, July 9, 2014
The ROS declined and HO-1 increased after the thawing of human seminiferous tubules. Slow freezing is more effective than vitrification in terms of HO-1 up-regulation and ROS decrease.

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Association of abdominal obesity insulin resistance and oxidative stress in adipose tissue in women with polycystic ovary syndrome

Tuesday, June 17, 2014
The strong correlation of insulin resistance and oxidative stress at the visceral adipose tissue level suggests that local oxidative stress and abnormalities of insulin signaling in the adipose tissue play critical roles in polycystic ovary syndrome insulin resistance.

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Pigment epithelium derived factor PEDF exerts antioxidative effects in granulosa cells

Tuesday, June 10, 2014
Recombinant pigment epithelium–derived factor can protect granulosa cell viability in oxidative stress conditions by increasing SOD-1 and GPX- 2 mRNA levels, decreasing the protein level of BAX, and inducing AKT phosphorylation.

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Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility

Thursday, February 20, 2014
Antioxidant intake and time to pregnancy (TTP) among couples treated for infertility was examined. Increased b-carotene, vitamin C, or vitamin E intakes are associated with shorter TTP in specific subgroups.

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Peroxynitrite affects the cumulus cell defense of metaphase II mouse oocytes leading to disruption of the spindle structure in vitro

Wednesday, July 31, 2013
Peroxynitrite generated in inflammatory states disrupts the cumulus oocyte complex and the spindle apparatus by dispersing and compromising the viability of cumulus cells, which may lead to infertility.

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Proteomic analysis of seminal plasma from infertile patients with oligoasthenoteratozoospermia due to oxidative stress and comparison with fertile volunteers

Wednesday, July 31, 2013
The largest proteomic data set to date of seminal plasma from idiopathic oligoasthenoteratozoospermia (iOAT) and fertile subjects is presented, with 46 proteins implicated in oxidative stress and immune response in iOAT.

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Interaction between oviductal epithelial cells and spermatozoa underlies a systems biology approach to treating infertility

Thursday, March 28, 2013
Reflections on "Cell membrane proteins from oviductal epithelial cell line protect human spermatozoa from oxidative damage" by Chiu et al.

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Cell membrane proteins from oviductal epithelial cell line protect human spermatozoa from oxidative damage

Thursday, March 28, 2013
Cell membrane proteins from an oviductal epithelial cell line have protective effects on spermatozoa against oxidative stress.

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Two dimensional differential in gel electrophoresis based proteomics of male gametes in relation to oxidative stress

Thursday, March 28, 2013
Proteomic analysis shows that differences in protein expression in spermatozoa producing higher levels of ROS may play a role in the pathophysiology of male infertility.

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Polycystic ovary syndrome offspring display increased oxidative stress markers comparable to gestational diabetes offspring

Friday, March 1, 2013
The present study demonstrated that in PCOS neonates, the oxidative stress status was similar to that of GDM neonates and strongly associated with their mothers’ oxidative status.

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Metformin decreases serum 8 hydroxy 2 deoxyguanosine levels in polycystic ovary syndrome

Monday, February 4, 2013
A double-blind, randomized, placebo-controlled trial on the effects of metformin on serum levels of 8-hydroxy-20-deoxyguanosine (8-OHdG) in women with polycystic ovary syndrome showed levels were statistically significantly reduced versus placebo.

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The aging ovary The poor granulosa cells

Wednesday, January 2, 2013
This review focuses on current knowledge about possible involvement of oxidative and carbonyl stress in the aging follicle.

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Aging gonads glands and gametes Immutable or partially reversible changes

Wednesday, January 2, 2013
Decreased ovarian testosterone production, granulosa cell dysfunction, oocyte telomere shortening and mitochondrial defects, and sperm DNA fragmentation all contribute to reproductive aging. Mitigating strategies are discussed.

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Sphingsine 1 phosphate inhibits H2O2 induced granulosa cell apoptosis via the PI3K Akt signaling pathway

Thursday, September 27, 2012
Sphingosine-1-phosphate treatment can inhibit apoptosis of granulosa cells in response to oxidative stress induced by H2O2, and the protective effect of S1P is mediated through the PI3K/Akt pathway.

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Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis

Tuesday, June 12, 2012
Infertile women with endometriosis have an altered balance between pro-oxidant and antioxidant activities that may have an impact on folliculogenesis and adequate embryo development.

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The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis

Thursday, June 7, 2012
Immortalized ectopic endometriotic stromal cells produced complement C3 and pentraxin-3 as major secretory proteins in comparison to eutopic counterparts, and revealed different regulation in iron metabolism.

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Androgen signaling in decidualizing human endometrial stromal cells enhances resistance to oxidative stress

Friday, June 1, 2012
Androgens inhibit cell death of decidualizing endometrial stromal cells exposed to oxidative stress signals. Therefore, androgens might play a critical role for decidua processes of embryo implantation and trophoblast invasion.

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Sex-related differences in association of oxidative stress status with coronary artery disease

Friday, May 25, 2012
Oxidative stress status, a powerful predictor of coronary artery disease in women, has important implications for the differences between sexes in ischemic disease physiopathology.

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