Maternal undernutrition induces premature reproductive senescence in adult female rat offspring

Monday, December 29, 2014
An adverse uterine nutritional environment during pregnancy results in premature reproductive senescence in adult rats.

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Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes

Wednesday, July 30, 2014
The ability of murine ovarian hormone synthesis became abnormal and the ovarian tissue behaved insulin resistance, after treated with dexamethasone, in vivo and in vitro; the Chinese herbal extract cryptotanshinone was found to partially antagonize their behavior.

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Melatonin influences on steroidoigenic gene expression in the ovary of pinealectomized rats

Wednesday, June 25, 2014
Because Cyp17a1 expression level was increased in the theca interna and interstitial cells in pinealectomized rats receiving vehicle, melatonin may influence CYP17A1 expression and steroidogenesis in the ovaries.

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Effect of detorsion alone and in combination with enoxaparin therapy on ovarian reserve and serum antimüllerian hormone levels in a rat ovarian torsion model

Monday, June 2, 2014
Experimental study was designed to investigate the effect of enoxaparin treatment combination with ovarian detorsion on ovarian reserve and we found this therapy is more effective than detorsion alone treatment.

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Generation of multioocyte follicles in the peripubertal rat ovary Link to the invasive capacity of granulosa cells

Wednesday, April 30, 2014
Contrary to previous assumptions, multi-oocyte follicles (MOFs) are frequently observed in the pubertal ovary. Follicle fusion, associated with granulosa cell invasiveness, appears to be the major mechanism for MOF generation.

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The artificial ovary Any new step is a step foward

Monday, March 31, 2014
Reflections on "A new step toward the artificial ovary: survival and proliferation of isolated murine follicles after autologous transplantation in a fibrin scaffold" by Luyckx et al.

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The Kiss1 system and polycystic ovary syndrome lessons from physiology and putative pathophysiologic implications

Friday, June 28, 2013
Potential implications of alterations of the Kiss1 system in the pathophysiology of polycystic ovary syndrome are discussed. The limited experimental and clinical evidence supporting such a role is summarized.

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Preservation of human ovarian follicles within tissue frozen by vitrification in a xeno free closed system using only ethylene glycol as a permeating cryoprotectant

Friday, June 28, 2013
Clinical-grade vitrification of human ovarian tissue in fertility preservation, with the use of only one permeating cryoprotectant, ethylene glycol, in a closed system results in intact follicular ultrastructure.

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Involvement of the ganglion cholinergic receptors in gonadotropin releasing hormone catecholamines and progesterone release in rat ovary

Friday, May 31, 2013
Ganglionic cholinergic stimulation produces changes in ovarian release of progesterone, gonadotropin-releasing hormone, noradrenaline, and adrenaline; the ovarian nerve plexus regulates these mechanisms through the release of different neurotransmitters.

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Small glutamine rich tetratricopeptide repeat containing protein alpha is present in human ovaries but may not be differentially expressed in relation to polycystic ovary syndrome

Friday, May 31, 2013
Small glutamine-rich tetratricopeptide repeat–containing protein alpha is expressed in human ovarian tissues and has the potential to modulate androgen receptor signaling, but expression levels may not be abnormal in polycystic ovary syndrome.

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Peripubertal changes in circulating antimullerian hormone levels in girls

Friday, May 31, 2013
Rate of ovarian primordial follicle recruitment increases prepubertally then declines again following the onset of puberty, while ovarian follicle activity continues to increase. These changes seem to track with the age of menarche.

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Different levels of leptin regulate different target enzymes involved in progesterone synthesis

Thursday, March 28, 2013
Leptin is able to regulate the expression of different target enzymes throughout the P synthesis, such as P450scc and 3bHSD, in a dose-dependent manner.

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Modulation of microvascular permeability in the preovulatory rat ovary by an ovulatory gonadotropin stimulus

Friday, March 1, 2013
Preovulatory gonadotropin stimulation induces changes in ovarian permeability, with an increase in the radii of the small and large pores and a threefold increase in the large pore fraction of the hydraulic conductance.

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Proteomic Biomarkers for Ovarian Cancer risk in Women with Polycystic Ovary Syndrome A Systematic Review and Biomarker Database Integration

Thursday, November 29, 2012
The biomarkers calreticulin, fibrinogen-γ, superoxide dismutase, vimentin, malate dehydrogenase, and lamin B2 could help improve our understanding of the links between polycystic ovary syndrome (PCOS) and ovarian cancer (OC) and could potentially be used to identify subgroups of women with PCOS at increased risk of OC. More studies are required to further evaluate the role these biomarkers play in women with PCOS and OC.

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Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rat

Thursday, November 1, 2012
We describe the existence of a specific postnatal window of vulnerability during which estradiol valerate exposure irreversibly programs changes in the follicular development, ovulation, and cyclic estrual activity of rats.

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The next (re)generation of ovarian biology and fertility in women: is current science tomorrow’s practice?

Thursday, June 28, 2012
We present an overview of gametogenesis from stem cells, with emphasis on generation of human oocytes, future research objectives for this area of work, and potential clinical applications involving human oogonial stem cells.

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Developmental programming: prenatal testosterone excess disrupts anti-Müllerian hormone expression in preantral and antral follicles

Thursday, May 24, 2012
Prenatal T leads to changes in anti-Mullerian hormone protein expression that likely accounts for the increased follicular recruitment and persistence found in this animal model of PCOS.

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Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells

Friday, May 11, 2012
In the human ovary, GDF-3, an inhibitor of BMP cytokines, was detected in granulosa cells and oocytes, and its expression was regulated by BMP cytokines.

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Viability and function of the cryopreserved whole rat ovary: comparison between slow-freezing and vitrification

Friday, May 4, 2012
Initial findings suggest that a moderate concentration of the cryoprotectant dimethyl sulfoxide (DMSO) is superior to a high DMSO concentration for both vitrification and slow freezing.

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The impairment of reproduction in db/db mice is not mediated by intraovarian defective leptin signaling

Friday, May 4, 2012
We report on how impairment of reproduction in db mice is not mediated by intraovary intact/defective leptin signaling even in the face of a significantly divergent modulation by gonadotropins.

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