Fertility preservation in pre pubertal girls with cancer The role of ovarian tissue cryopreservation

Tuesday, December 29, 2015
We discuss the indications for ovarian tissue cryopreservation in young patients with cancer, and future potential uses for this tissue.

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Ovarian cortex transplantation Time to move on from experimental studies to open clinical application

Thursday, October 29, 2015

Authors:
Jacques Donnez, M.D., Ph.D., Marie-Madeleine Dolmans, M.D., Ph.D., César Diaz, M.D., Ph.D., Antonio Pellicer, M.D., Ph.D.…

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Evaluation of a human ovarian follicle isolation technique to obtain disease free follicle suspensions before safely grafting to cancer patients

Tuesday, September 1, 2015
Cancer cells present in ovarian tissue may be found in isolated follicle suspensions. Manually washing the follicles three times proved effective for eliminating cancer cells while maintaining good follicle viability.

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Xenotransplantation of cryopreserved human ovarian tissue A systematic review of MII oocyte maturation and discussion of it as a realistic option for restoring fertility after cancer treatment

Monday, June 1, 2015
This review discusses the value of xenotransplantation as a tool in reproductive biology and ethical and potential safety issues associated with ovarian tissue xenotransplantation as a means of restoring fertility.

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Searching for metastases in ovarian tissue before autotransplantation A tailor made approach

Friday, January 30, 2015
To exclude minimal residual disease in remaining ovarian tissue after harvesting the ovarian cortex for cryopreservation, a tailor-made approach is recommended.

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Sphingosine 1 phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice

Tuesday, May 27, 2014
Antiapoptotic drug sphingosine-1-phosphate suppresses follicular depletion associated with chemotherapeutic agent cyclophosphamide treatment in human fetal ovarian xenografts, potentially providing a new option to prevent infertility associated with cancer treatments.

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Does stimulation with human gonadotropins and gonadotropin-releasing hormone agonist enhance and accelerate the developmental capacity of oocytes in human ovarian tissue xenografted into severe combined immunodeficient mice

Wednesday, April 30, 2014
After xenotransplantation, human primordial follicles can be matured to metaphase II oocytes even without stimulation. Administering human gonadotropin and GnRH agonist does not enhance the developmental capacity of oocytes in xenografts.

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Risk of transferring malignant cells with transplanted frozen thawed ovarian tissue

Tuesday, April 30, 2013
For some cancers, especially hematologic pathologies, transplanting frozen-thawed ovarian tissue can transfer malignant cells. This paper overviews this risk for different cancers.

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Emergency IVF versus ovarian tissue cryopreservation decision making in fertility preservation for female cancer patients

Tuesday, April 30, 2013
This article examines emergency IVF and ovarian tissue storage and current data on their reproductive outcomes in cancer patients. These data challenge the concept that these techniques should be labeled “experimental.”

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Live birth after orthotopic grafting of autologous cryopreserved ovarian tissue and spontaneous conception in Italy

Wednesday, January 2, 2013
A live birth was obtained after frozen/thawed ovarian tissue autologous transplantation in a patient with precocious ovarian failure after chemotherapy and bone marrow transplantation.

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Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation

Friday, May 25, 2012
Overnight transportation of ovarian tissue before cryopreservation is possible, as shown by this report of a live birth; however, further research is needed before the procedure can be used in clinical practice.

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Fertility preservation for social indications: a cost-based decision analysis

Wednesday, May 23, 2012
Neither oocyte cryopreservation nor ovarian tissue cryopreservation appears to be cost-effective for healthy women planning delayed childbearing.

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