Artificial oocyte activation with calcium ionophore does not cause a widespread increase in chromosome segregation errors in the second meiotic division of the oocyte

Tuesday, March 1, 2016
Artificial oocyte activation with calcium ionophore does not cause a widespread increase in chromosome segregation errors in the second meiotic division. However, we recommend that it is applied selectively to patients with specific indications.

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Total levels localization patterns and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection

Tuesday, September 1, 2015
Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C Zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection, but not after in vitro fertilization.

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Sperm content of postacrosomal WW binding protein is related to fertilization outcomes in patients undergoing assisted reproductive technology

Wednesday, July 30, 2014
Sperm content of the postacrosomal head protein PAWP is positively correlated with successful fertilization and normal preimplantation embryonic development after intracytoplasmic sperm injection.

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Variance in total levels of phospholipase C zeta PLCζ in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability

Wednesday, January 2, 2013
Examination of total levels and localisation patterns of PLCζ in control and patient sperm. Sperm from control and OAD males exhibited significant variance in total levels and localization patterns of PLCζ protein.

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Phospholipase C zeta rescues failed oocyte activation in a prototype of male factor infertility

Wednesday, January 2, 2013
Oocytes expressing mutant sperm phospholipase Cz (PLCz) fail to activate, but microinjection of wild-type human PLCz rescues failed activation and triggers embryo development.

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Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile male by use of minisequencing of individual sperm and expression in somatic cells

Thursday, June 7, 2012
Investigating contributory factors to infertility in a man with two phospholipase C zeta (PLCz) mutations found loss-of-activity mutations in PLCz potentially resulting in a slower rate of mutant protein transcription.

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Fertilization outcome could be regulated by binding of oviductal plasminogen to oocytes and by releasing of plasminogen activators during interplay between gametes

Thursday, May 31, 2012
Plasminogen is present in the oviductal fluid. Plasminogen and plasminogen activators are present in oolemma and zona pellucida of matured oocytes. After IVF, the immunoreactivity for plasminogen and its activators in oocytes decreases. Presence of plasminogen in the IVF medium decreases polyspermy rates.

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