Increased progesterone receptor expression in uterine leiomyoma Correlation with age number of leiomyomas and clinical symptoms

Monday, June 29, 2015
Progesterone receptor-B mRNA levels in leiomyoma tissue are directly associated with the number of tumors and inversely correlated with the intensity of intermenstrual bleeding and dysmenorrhea.

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Clinical significance of melatonin receptors in the human myometrium

Wednesday, July 30, 2014
Melatonin receptor expression is upregulated in the pregnant human myometrium at the time of labor, leading to synergism with oxytocin signaling to promote high uterine contractility and parturition at night.

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Alternative therapies in management of leiomyomas

Thursday, June 26, 2014
Magnetic resonance imaging–guided focused ultrasound surgery, cryomyolysis, and transcervical temporary occlusion of the uterine arteries are emerging, minimally invasive options for leiomyomas therapy.

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Liarozole inhibits transforming growth factor β3 mediated extracellular matrix formation in human three dimensional leiomyoma cultures

Wednesday, June 25, 2014
Leiomyoma and myometrial cells in three-dimensional leiomyoma cultures treated with liarozole resulted in decreased expression of transforming growth factor b3 (TGF-b3) and TGF-b3-regulated extracellular matrix.

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Current understanding of somatic stem cells in leiomyoma formation

Wednesday, April 30, 2014
In this work, we offer an overview of the current knowledge about somatic stem cells in murine and human myometrium and their putative implication in human leiomyoma formation.

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Estradiol and tamoxifen enhance invasion of endometrial stromal cells in a three dimensional coculture model of adenomyosis

Tuesday, December 31, 2013
Estradiol and tamoxifen enhance invasion of both adenomyosis-derived stromal cells and control stromal cells when grown on collagen or in coculture with myocytes.

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Gonadotropin releasing hormone GnRH agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production

Thursday, November 1, 2012
Gonadotropin-releasing hormone analogues leuprolide acetate and cetrorelix acetate directly regulate extracellular matrix components COL1A1, fibronectin, and versican in human uterine leiomyoma cells relative to patient-matched myometrial cells.

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Development and validation of a three-dimensional in vitro model for uterine leiomyoma and patient-matched myometrium

Wednesday, May 30, 2012
Immortalized leiomyoma and myometrial cells grown in a three-dimensional format maintain the molecular phenotype of the progenitor tissues and create extracellular matrix.

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