Aging and the environment affect gamete and embryo potential Can we intervene

Tuesday, March 1, 2016
A discussion of the enhancing factors contributing to gamete competence and the mitigating factors reducing gamete (and therefore embryo) potential promise to reduce the number of euploid embryos failing to produce normal viable deliveries.

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Mitochondrial DNA content as a viability score in human euploid embryos Less is better

Tuesday, September 1, 2015
Higher mitochondrial DNA content in euploid human embryos is related to poor implantation potential and may be indicative of reduced metabolic fuel during oocyte maturation.

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Simultaneous assessment of aneuploidy polymorphisms and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform

Monday, July 14, 2014
A novel microarray platform was developed offering the possibility of combined aneuploidy screening, genetic fingerprinting, and mitochondrial DNA (mtDNA) assessment of embryos. Associations between mtDNA and maternal age are reported.

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Mitochondrial activation in the growth restricted fetus of monochorionic twins

Friday, June 28, 2013
Mitochondria are significantly activated in growthrestricted fetuses, which may be a response to adverse intrauterine environments rather than to genetic factors.

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Blastocyst preimplantation genetic diagnosis PGD of a mitochondrial DNA disorder

Thursday, November 1, 2012
Blastocyst PGD of mutation load and gender was applied for the first time. Results demonstrate that the trophectoderm is predictive of inner cell mass and newborn mutation loads and that simultaneous gender selection can be used to reduce the transgenerational risk of inheritance.

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