Decreased expression of microRNA 29 family in leiomyoma contributes to increased major fibrillar collagen production

Monday, May 2, 2016

Authors:
Erica E. Marsh, M.D., M.S.C.I., Marissa L.…

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MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment

Tuesday, December 29, 2015
MicroRNAs can be reproducibly detected in blastocyst-spent media and most likely belong to trophectoderm cells. Primary clinical data suggest testing these noninvasive biomarkers for embryo selection in IVF cycles.

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MicroRNA A step beyond bulk seminal parameters

Tuesday, September 1, 2015
Reflections on "Spermatozoa from patients with seminal alterations exhibit a differential miRNA profile" by Salas-Huetos et al.

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Spermatozoa from patients with seminal alterations exhibit a differential micro ribonucleic acid profile

Tuesday, September 1, 2015
Spermatozoa from infertile patients with asthenozoospermia, teratozoospermia, or oligozoospermia exhibit a differential miRNA profile associated with biological processes related to their particular seminal alterations.

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MicroRNAome in decidua A new approach to assess the maintenance of pregnancy

Monday, March 30, 2015
MicroRNA expression profiles were significantly altered between miscarriage and normal pregnancy deciduas. MicroRNA-199b-5p and SGK1 were detected to determine their interaction in pregnancy maintenance in vivo and in vitro.

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MicroRNA 22 3p is downregulated in the plasma of Han Chinese patients with premature ovarian failure

Friday, February 27, 2015
MiR-22-3p showed a lower expression level in 140 premature ovarian failure (POF) patients and was modestly effective in distinguishing POF from control subjects. It may be a consequence of the pathologic process of POF.

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Panel of five microRNAs as potential biomarkers for the diagnosis and assessment of male infertility

Tuesday, July 1, 2014
Quantitative real-time polymerase chain reaction validation reveals that a set of five miRNAs deserves to be used as a diagnostic test along with other routine clinical tests, such as conventional semen and histologic analysis, to improve male infertility assessment and diagnosis.

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New insights into the expression profile and function of micro ribonucleic acid in human spermatozoa

Wednesday, June 25, 2014
Human spermatozoa contain a stable population of miRNAs potentially related to embryo development and spermatogenesis.

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MicroRNAs and gynecological reproductive diseases

Sunday, June 1, 2014
This review covers not only impact of microRNA dysregulation in the origin of gynecological disease, but also the potential diagnostic and therapeutic role that microRNA may play in gynecological pathologies.

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MicroRNAs Key gene expression regulators

Sunday, June 1, 2014
Review of the basic principles of miRNA biology, including miRNA biogenesis, mechanisms of action, detection methods, functional effects, and possibilities as biomarkers and as pharmacologic agents in human reproduction.

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MicroRNAs in human reproduction Small molecules with crucial regulatory roles

Sunday, June 1, 2014
In this issue’s Views and Reviews, the authors present current knowledge regarding the involvement of microRNAs in several aspects of human reproduction and discuss its future implications for clinical practice.

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Human embryos secrete microRNAs into culture media a potential biomarker for implantation

Wednesday, April 30, 2014
Human blastocysts secrete microRNAs into culture media, and MicroRNAs may be a noninvasive marker for delivery after in vitro fertilization.

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MicroRNA expression profiles in human testicular tissues of infertile men with different histopathologic patterns

Tuesday, December 31, 2013
Microarray and real-time polymerase chain reaction studies reveal that microRNAs are differentially expressed in normal versus different testicular histopathologic patterns and have therapeutic potential for the development of biomarkers for male infertility.

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MicroRNA miR 145 inhibits proliferation invasiveness and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors

Thursday, March 28, 2013
MicroRNA miR-145 inhibits proliferation, invasiveness, and the stem cell phenotype of endometriotic cells by targeting multiple cytoskeletal elements and pluripotency factors, emerging as a novel target for therapeutic approaches.

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Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments

Thursday, March 28, 2013
Microarray and real-time polymerase chain reaction (PCR) studies reveal that microRNAs are differentially expressed in normal versus spermatogenically impaired males and have therapeutic potential for the development of biomarkers for male infertility.

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Investigation of gene expression profiles before and after embryonic genome activation and assessment of functional pathways at the human metaphase II oocyte and blastocyst stage

Friday, March 1, 2013
Gene expression profiling at the human oocyte and blastocyst stage has identified similarities and differences in processes before and after embryonic genome activation.

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Basic concepts of epigenetics

Friday, March 1, 2013
Epigenetic mechanisms maintain mitotically heritable differences in gene expression potential without altering the primary DNA sequence. This review highlights epigenetic mechanisms that are relevant to normal and abnormal human developmental and differentiation processes.

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Targeting of syndecan 1 by micro ribonucleic acid miR 10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic millieu and interleukin 6 secretion

Friday, March 1, 2013
Syndecan-1 inhibits invasiveness of epithelial endometriotic cells by modulating matrix metalloproteinases MMP-2 and MMP-9, plasminogen activator inhibitor-1, and interleukin-6 and is regulated by the microRNA miR-10b, both possible novel targets for therapeutic approaches.

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MicroRNA expression in the human blastocyst

Friday, March 1, 2013
Human blastocysts express microRNAs, many of which are important for embryonic and stem cell development. Differential expression of microRNAs based on ploidy and sex were discovered.

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Roles of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas

Thursday, June 7, 2012
PDCD-4 is unexpectedly elevated in leiomyomas, but normal myometrium does not express the protein; the expected inverse correlation of microRNA-21 and its target PDCD-4 is absent in fibroids.

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