Changes in sperm methylation profile A potential cause of infertility and a handle to monitor improvements in genetic and lifestyle interactions

Tuesday, December 29, 2015

Authors:
Moira O’Bryan, Ph.D., Michelle Lane, Ph.D.…

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Aberrant sperm DNA methylation predicts male fertility status and embryo quality

Monday, November 30, 2015
Genome wide sperm DNA patterns in fertile and infertile men are highly predictive of fertility status and may predict embryonic developmental capacity during IVF.

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Histone methylation and acetylation in ejaculated human sperm Effects of swim up and smoking

Monday, June 1, 2015
This study demonstrates a decrease of global methylation and unchanged acetylation level in ejaculated human sperm after the swim-up preparation.

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Deoxyribonucleic acid methylation profiling of single human blastocysts by methylated CpG island amplification coupled with CpG island microarray

Monday, June 1, 2015
Methylated CpG-island amplification coupled with CpG-island microarray was used to assess DNA methylation in individual in vitro–derived human blastocysts, revealing 121 CpG islands that were hypermethylated in all 5 embryos.

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Methylation status of human chorionic gonadotropin beta subunit promoter and TFAP2A expression as factors regulating CGB gene expression in placenta

Wednesday, June 11, 2014
During pregnancy, regulation of the expression of human chorionic gonadotropin beta subunit genes correlates with methylation of their promoters and TFAP2A expression.

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Paternal age and sperm methylation status

Monday, September 30, 2013
Reflections on "Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels" by Jenkins et al.

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Epigenetic disorders and male subfertility

Friday, March 1, 2013
Epigenetic causes of male infertility are highlighted by increasing arguments in favor of key roles of DNA methylation, histone modifications, and spermatozoal RNA in the spermatogenesis process and embryo formation.

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Allotransplantation of cryopreserved prepubertal mouse ovaries restored puberty and fertility without affection methylation profile of Snrpn DMR

Wednesday, January 2, 2013
Vitrification of prepubertal mouse ovaries did not affect the methylation profile of Snrpn-DMR or their development and fertility potential.

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Effect of 5-aza-2′-deoxycytidine on methylation of the putative imprinted control region of H19 during the in vitro development of vitrified bovine two-cell embryos

Thursday, June 7, 2012
H19 imprinted control region methylation levels significantly increased in vitrified two-cell embryos and their derived blastocysts; 5-aza-dC significantly reduced H19 imprinted control region methylation and increased H19 expression in blastocysts derived from vitrified embryos.

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Epigenetics of the male gamete

Thursday, May 24, 2012
The epigenome of human sperm demonstrates a historical record of spermatogenesis as well as a poising of key developmental genes that may be functional in embryogenesis.

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