Artificial oocyte activation with calcium ionophore does not cause a widespread increase in chromosome segregation errors in the second meiotic division of the oocyte

Tuesday, March 1, 2016
Artificial oocyte activation with calcium ionophore does not cause a widespread increase in chromosome segregation errors in the second meiotic division. However, we recommend that it is applied selectively to patients with specific indications.

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Fragmentation of human cleavage stage embryos is related to the progression through meiotic and mitotic cell cycles

Friday, January 30, 2015
The appearance of the meiotic spindle and the durations of the first, second, and third mitoses are related to the degree of fragmentation of human embryos.

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Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during oocyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization

Monday, December 29, 2014
We discuss how follicular fluid cortisol levels may regulate cumulus cell lipolysis during oocyte meiotic resumption and affect oocyte quality during in vitro fertilization.

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In every end there is a beginning Telomeres in male reproduction

Monday, July 14, 2014
Reflections on "Telomere homeostasis is compromised in spermatocytes from patients with idiopathic infertility" by Reig-Viader et al.

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Telomere homeostasis is compromised in spermatocytes from patients with idiopathic infertility

Monday, June 2, 2014
The telomeric distribution of both the noncoding telomeric RNA (TERRA) and the protein component of telomerase (TERT) is disrupted in spermatocytes I of men with idiopathic infertility.

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Chromosome size morphology and gene density determine bivalent positioning in metaphase I human spermatocytes

Thursday, February 20, 2014
Proximity analyses of bivalents in human spermatocytes demonstrated a nonrandom arrangement in metaphase I influenced by chromosome size, gene density, and acrocentric chromosome morphology.

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Detection and quantification of maternal effect gene transcripts in mouse second polar bodies potential markers of embryo developmental competence

Friday, May 31, 2013
Differences in gene expression in individual second polar bodies may be potential markers for minimally invasive testing of embryo developmental competence.

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Follicle microenvironment associated alterations in gene expression in the mouse oocyte and its polar body

Thursday, March 28, 2013
Changes in the follicle microenvironment lead to quantifiable differences in gene expression in individual oocytes and their polar bodies.

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Telomeres and Human Reproduction

Wednesday, January 2, 2013
Telomere dynamics differ between the female and male germ lines: oocytes have short telomeres, and their erosion recapitulates the reproductive aging phenotype, and telomere length in sperm increases with age.

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The genetic origin of Klinefelter syndrome and its effect on spermatogenesis

Tuesday, June 12, 2012
We performed a literature review of the genetic etiology of Klinefelter syndrome, its effect on spermatogenesis, and the health of children born from men with Klinefelter syndrome following assisted reproductive technology.

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Age-associated alteration of oocyte-specific gene expression in polar bodies: potential markers of oocyte competence

Friday, June 8, 2012
Differences in gene expression in individual polar bodies of metaphase II oocytes may be potential markers for minimally invasive testing of oocyte competence.

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Identification of phosphodiesterase 9A as a cyclic guanosine monophosphate–specific phosphodiesterase in germinal vesicle oocytes: a proposed role in the resumption of meiosis

Thursday, June 7, 2012
Phosphodiesterase 9A (PDE9A), a cyclic guanosine monophosphate–specific phosphodiesterase detectable in germinal vesicle oocytes, likely promotes maturation events upstream of PDE3A, making it a candidate target for nonhormonal contraception.

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Strain-specific spontaneous activation during mouse oocyte maturation

Thursday, June 7, 2012
Oocyte spontaneous activation, an irregularity of the cell cycle that can lead to ovarian teratomas, has genetic variation among inbred mouse strains, and is sensitive to the culture environment.

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Insufficient histone-3 lysine-9 deacetylation in human oocytes matured in vitro is associated with aberrant meiosis

Friday, June 1, 2012
The increased incidence of aberrant meiosis in in vitro–matured human oocytes correlates with persistence of lysine-9 acetylation of histone-3.

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