Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments

Thursday, March 28, 2013
Microarray and real-time polymerase chain reaction (PCR) studies reveal that microRNAs are differentially expressed in normal versus spermatogenically impaired males and have therapeutic potential for the development of biomarkers for male infertility.

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The use of genomics proteomics and metabolomics in identifying biomarkers of male infertility

Monday, March 18, 2013
Biomarkers hold the keys to accurate diagnosis and treatment of male factor infertility. Their discovery is critical in eliminating invasive testing in the infertile male while developing novel targets for treatment.

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Novel technologies for selecting the best sperm for in vitro fertilization and intracytoplasmic sperm injection

Monday, March 18, 2013
This review examines new techniques that are designed to prepare a clean “normal” sperm population or that assist in selecting an individual “normal” spermatozoon.

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Epigenetic disorders and male subfertility

Friday, March 1, 2013
Epigenetic causes of male infertility are highlighted by increasing arguments in favor of key roles of DNA methylation, histone modifications, and spermatozoal RNA in the spermatogenesis process and embryo formation.

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The clinical utility of sperm DNA integrity testing A guideline

Friday, March 1, 2013
This document describes the basics of sperm DNA integrity; assesses the evidence pertaining to the clinical utility of sperm DNA integrity testing; and targets areas that require more study.

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Clinical value of sperm DNA damage should be assessed in motile sperm fraction rather than whole ejaculated sperm

Monday, February 4, 2013
DNA damage results of ejaculated sperm do not accurately reflect DNA status of motile sperm, so sperm DNA damage should be assessed in motile sperm fraction rather than whole ejaculated sperm.

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Down regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia while up regulation of the channel by Sheng Jing San treatment improves…

Monday, February 4, 2013
In rats with cyclophosphamide-induced asthenozoospermia, CatSper1 and sperm motility were significantly reduced, whereas Sheng-Jing-San treatment restored the cyclophosphamide-induced down-regulation of CatSper1 and improved the sperm motility.

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Raw and Test Thaw Semen Parameters after Cryopreservation among Men with Newly Diagnosed Cancer

Monday, February 4, 2013
In cryopreserved semen from men with newly diagnosed cancer, all specimens show severe decline in postthaw total motile sperm count, with most severe reductions in the myeloid leukemia group.

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Serum INSL3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low dose hCG A randomized controlled trial

Wednesday, January 2, 2013
Serum INSL3 correlates with intratesticular testosterone during hCG administration. Measurement of serum INSL3 may be a useful biomarker of intratesticular testosterone during hCG treatment of infertile men.

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Role of increased male age in IVF and egg donation Is sperm DNA fragmentation responsible

Wednesday, January 2, 2013
A review of potential risks to offspring as well as the impact on fertility of advancing male age and a discussion of mechanisms by which male age may impact sperm.

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Variance in total levels of phospholipase C zeta PLCζ in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability

Wednesday, January 2, 2013
Examination of total levels and localisation patterns of PLCζ in control and patient sperm. Sperm from control and OAD males exhibited significant variance in total levels and localization patterns of PLCζ protein.

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Defective protein kinase A and C pathways are common causes of disordered zona pellucida ZP induced acrosome reaction in normozoospermic infertile men with normal sperm-ZP binding

Wednesday, January 2, 2013
Defective protein kinase A and C pathways are commonly associated with disordered ZP–induced acrosome reaction in normozoospermic infertile men with normal sperm-ZP binding.

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Association prevalence and clearance of human papillomavirus and antisperm antibodies in infected semen samples from infertile patients

Wednesday, January 2, 2013
This clinical study demonstrates the significant association between HPV sperm infection and ASAs and their clearance time in infertile patients.

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Phospholipase C zeta rescues failed oocyte activation in a prototype of male factor infertility

Wednesday, January 2, 2013
Oocytes expressing mutant sperm phospholipase Cz (PLCz) fail to activate, but microinjection of wild-type human PLCz rescues failed activation and triggers embryo development.

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Determination of Male Infertility Is the 2010 WHO Reference Range Helpful or Confusing

Thursday, November 29, 2012
Reflections on Murray et al. "The Effect of the New 2010 World Health Organization Criteria for Semen Analyses on Male Infertility"

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Aromatase inhibitors for male infertility

Thursday, November 29, 2012
Aromatase inhibitors increase serum testosterone levels and can improve sperm production for infertile men with low serum testosterone and increased testosterone/estradiol ratios.

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The Effect of the New 2010 World Health Organization Criteria for Semen Analyses on Male Infertility

Thursday, November 29, 2012
Fifteen percent of men with previously abnormal semen analysis would be reclassified as normal by the 2010 WHO criteria. This may lead to less male infertility diagnosis or evaluation.

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Genetic variants in the ETV5 gene in fertile and infertile men with nonobstructive azoospermia associated with Sertoli cell-only syndrome

Thursday, September 27, 2012
We showed that the homozygous +48845 G>T (TT allele) variant in the ETV5 gene is associated with Sertoli cell–only (SCO) syndrome and nonobstructive azoospermia (NOA) in Australian men.

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ETV5 mutations Revisiting Sertoli cell-only syndrome

Thursday, September 27, 2012
Reflections on "Genetic variants in the ETV5 gene in fertile and infertile men with nonobstructive azoospermia associated with Sertoli cell–only syndrome"

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Klinefelter Syndrome: How, What and Why?

Tuesday, June 12, 2012
This collection of articles written by a series of experts should help all those who deal with Klinefelter syndrome patients develop a much broader and scientifically based understanding of this common condition.

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Changes in the hormonal profile and seminal parameters with the use of aromatase inhibitors in the management of infertile men with low testosterone to estradiol ratios

Wednesday, June 6, 2012
Therapy with 2.5 mg letrozole or 1 mg anastrazole daily, in cases of infertile men with low T/E2 ratios, leads to a significant increase of T/E2 ratio, ejaculate volume, sperm motility, and total motile sperm count.

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Screening for partial AZFa microdeletions in the Y chromosome of infertile men – Is it of clinical relevance?

Wednesday, June 6, 2012
Assessing complete AZFa deletion is important in azoospermic men, but routine assessment of either USP9Y or DDX3Y microdeletions is unjustified, owing to their rarity and inconsistent impact on spermatogenesis.

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Food intake and social habits in male patients and its relationship to intracytoplasmic sperm injection outcomes

Thursday, May 31, 2012
Semen quality and ICSI outcomes may be influenced by food intake and social habits. Therefore, couples seeking assisted reproduction treatment must be advised about the drastic effects of both the male’s and female’s lifestyles on treatment success.

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Expression of BET genes in testis of men with different spermatogenic impairments

Thursday, May 31, 2012
Human BRDT is the only BET gene expressed exclusively in testicular germ cells. The BRDT protein is expressed in spermatocytes, round spermatids, elongated spermatids, and ejaculated spermatozoa.

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Male fertility: psychiatric considerations

Friday, May 25, 2012
Male infertility may be influenced by psychologic stress and psychotropic agents. Available literature is heterogeneous, and further studies are needed to demonstrate the relationship between stress, antidepressants, and male fertility.

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Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis

Thursday, May 24, 2012
Genome-wide sperm DNA methylation patterns were evaluated in abnormal protamine 1/protamine 2 ratio, abnormal IVF/intracytoplasmic sperm injection embryogenesis, and normozoospermic, fertile control men. Broadly aberrant methylation was observed in three patients.

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Semen analysis: looking for an upgrade in class

Thursday, May 24, 2012
Present-day semen analysis is better than it has ever been. However, alone, it does not meet modern day clinical diagnostic needs.

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A platform for evaluating sperm RNA biomarkers: dysplasia of the fibrous sheath—testing the concept

Friday, May 4, 2012
Correlative transcript pairs have suggested their potential use as biomarkers for male fertility. The results show that qPCR may provide a low-cost assay to assess dysplasia of the fibrous sheath.

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Orthotopic grafting of cryopreserved prepubertal testicular tissue: in search of a simple yet effective cryopreservation protocol

Friday, May 4, 2012
Solid-surface vitrification resulted in success rates similar to conventional uncontrolled slow freezing inpreserving the integrity and function of prepubertalmouse testicular tissue.

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