Panel of five microRNAs as potential biomarkers for the diagnosis and assessment of male infertility

Tuesday, July 1, 2014
Quantitative real-time polymerase chain reaction validation reveals that a set of five miRNAs deserves to be used as a diagnostic test along with other routine clinical tests, such as conventional semen and histologic analysis, to improve male infertility assessment and diagnosis.

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Urinary metabolome identifies signatures of oligozoospermic infertile men

Wednesday, June 25, 2014
The urinary metabolome could differentiate oligozoospermic infertile men from fertile men. The disrupted metabolic pathways reflected fertility reduction that may be tightly associated with energy consumption and antioxidant defenses in spermatogenesis.

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Estrogenic regulation of testicular expression of stem cell factor and c kit Implications in germ cell survival and male fertility

Wednesday, June 25, 2014
17b-estradiol unbalances the expression of SCF and c-kit in rat seminiferous tubules cultured ex vivo, which is accompanied by reduced proliferation and augmented apoptosis of germ cells.

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Genetic variants in the RABL2A gene in fertile and oligoasthenospermic infertile men

Wednesday, June 25, 2014
Among RABL2A genetic variants in male infertility, the 114391996 delC variant may confer a risk for oligoasthenospermia in Australian men.

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Integrative DNA methylation and gene expression analysis identifies discoidin domain receptor 1 association with idiopathic nonobstructive azoospermia

Tuesday, June 17, 2014
Aberrant DNA methylation and abnormal DDR1 gene expression is associated with men with idiopathic nonobstructive azoospermia.

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Sperm proteomics Fertility diagnostic testing beyond the semen analysis

Sunday, June 1, 2014
Reflections on "Acute epididymitis induces alterations in sperm protein composition" by Pilatz et al.

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We need a prospective varicocelectomy trial

Sunday, June 1, 2014
Controversy exists whether varicocelectomy improves pregnancy rates in couples with male infertility.

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Influence of ejaculatory abstinence on seminal total antioxidant capacity and sperm membrane lipid peroxidation

Tuesday, May 27, 2014
A single day of ejaculatory abstinence (EA) compared with 4 days of EA increased seminal total antioxidant capacity without a measurable effect on sperm membrane lipid peroxidation.

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DMRT1 mutations are rarely associated with male infertility

Monday, April 28, 2014
Because deletions of DMRT1 are found in XY gonadal dysgenesis, ovotesticular disorder, and male infertility, we sequenced DMRT1 in 171 male infertility patients and detected four possibly pathogenic mutations.

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Array based DNA methylation profiling in male infertility reveals allele specific DNA methylation in PIWIL1 and PIWIL2

Monday, March 31, 2014
Array-based DNA-methylation profiling identifies 471 CpGs as markers for idiopathic infertility in peripheral blood and suggests allele-specific DNA methylation of PIWIL1 and PIWIL2 genes to be associated with disturbed spermatogenesis.

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Prevalence of the Aurora kinase C c144delC mutation in infertile Moroccan men

Monday, March 31, 2014
The AURKC gene causes male infertility in humans. Here we demonstrate that the AURKC c.144delC has a relatively high carrier frequency in the Moroccan population.

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Development of a high resolution Y chromosome microarray for improved male infertility diagnosis

Monday, March 31, 2014
Array-comparative genomic hybridization is a robust higher resolution alternative to multiplex polymerase chain reaction for detection of chromosome Y microdeletions, increasing the diagnostic yield in male infertility.

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Phenotypic differences in mosaic Klinefelters patients as compared with nonmosaic Klinefelters patients

Monday, March 31, 2014
Men with mosaic Klinefelter syndrome (KS) seem to be more well androgenized than their non-mosaic KS counterparts, both with respect to hormones and sperm in the ejaculate.

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Sperm selected by both birefringence and motile sperm organelle morphology examination have reduced deoxyribonucleic acid fragmentation

Thursday, February 20, 2014
Birefringence and MSOME are effective to select sperm with improved nuclear status. We found that sperm selected by both these methods and no nuclear vacuoles have significantly lower DNA fragmentation.

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The effect of 5α reductase 2 deficiency on human fertility

Friday, January 31, 2014
Males homozygous for 5a-reductase deficiency are born with ambiguous external genitalia from reduced conversion of T to dihydrotestosterone.We discuss this syndrome and its impact on human fertility.

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MicroRNA expression profiles in human testicular tissues of infertile men with different histopathologic patterns

Tuesday, December 31, 2013
Microarray and real-time polymerase chain reaction studies reveal that microRNAs are differentially expressed in normal versus different testicular histopathologic patterns and have therapeutic potential for the development of biomarkers for male infertility.

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Dendritic cells in semen of infertile men Association with sperm quality and inflammatory status of the epididymis

Tuesday, December 31, 2013
The inflammatory status of the epididymis may be reflected by the abundance and activation status of dendritic cells in semen, which may affect sperm quality and fertility outcome.

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Testosterone use in the male infertility population prescribing patterns and effects on semen and hormonal parameters

Tuesday, December 31, 2013
In Canada, testosterone is not commonly used by men presenting for fertility investigation (1.3%). Testosterone cessation generally resulted in an increase in sperm counts. A subset of men remained azoospermic.

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Finasteride and male infertility A case for prospective collaborative research databases

Wednesday, November 27, 2013
Reflections on "Finasteride use in the male infertility population: effects on semen and hormone parameters" by Samplaski et al.

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Association of aberrant expression of sex determining gene fibroblast growth factor 9 with Sertoli cell only syndrome

Wednesday, November 27, 2013
Testicular fibroblast growth factor 9 (FGF9) is expressed in adult Leydig cells, and its expression is significantly decreased in patients with Sertoli cell–only syndrome. A promoter polymorphism of FGF9 contributes to its aberrant expression.

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Cysteine rich secretory protein 1 in seminal plasma potential biomarker for the distinction between obstructive and nonobstructive azoospermia

Thursday, October 31, 2013
Seminal CRISP1 was measured to distinguish between obstructive and nonobstructive azoospermia. The receiver operating characteristic plots demonstrated a high diagnostic accuracy for CRISP1 to diagnose the cause of azoospermia.

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Antioxidants enhance the recovery of three cycles of bleomycin etoposide and cisplatin induced testicular dysfunction pituitary testicular axis and fertility in rats

Monday, September 30, 2013
Antioxidants enhance recovery of testicular effects of therapeutically relevant dose levels of bleomycin, etoposide, and cisplatin. The antioxidants up-regulate germ cell renewal and recovery of Sertoli cell functions, fertility, and the pituitary-testis axis.

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Increased risk of cancer among azoospermic men

Friday, August 30, 2013
Men with azoospermia have an increased risk of subsequently developing cancer, suggesting a possible common etiology between azoospermia and cancer development.

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Relationship between advanced paternal age and male fertility highlights an impending paradigm shift in reproductive biology

Friday, June 28, 2013
Reflections on "Aging sperm negatively impacts in vivo and in vitro reproduction: a longitudinal murine study" by Katz-Jaffe et al.

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Single nucleotide polymorphism array analysis in men with idiopathic azoospermia or oligoasthenozoospermia syndrome

Friday, June 28, 2013
Investigation of 39 men with idiopathic infertility revealed a heterozygous partial deletion of the CLCA4 gene in one patient with cryptozoospermia, making CLCA4 a novel candidate gene for male factor infertility.

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Intracytoplasmic sperm injection outcome of ejaculated versus extracted testicular spermatozoa in cryptozoospermic men

Friday, May 31, 2013
Testicular sperm extraction is justified in patients with cryptozoospermia who fail to conceive by ICSI using ejaculated spermatozoa, as it offers a higher pregnancy rate.

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Y chromosome azoospermia factor region microdeletions are not associated with idiopathic recurrent spontaneous abortion in a Slovenian population association study and literature review

Tuesday, April 30, 2013
Azoospermia factor region microdeletions were not detected in Slovenian men with IRSA. Our comparisons with previous studies show that Y chromosome microdeletions are most likely not associated with IRSA.

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Treatment discontinuation in couples consulting for male infertility after failing to conceive

Thursday, March 28, 2013
Of the 1,345 couples who consulted for male factor infertility, 407 patients discontinued treatment principally due to painfulness of treatment and its ineffectiveness. Of these patients, 20% finally succeeded in having a child.

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Two dimensional differential in gel electrophoresis based proteomics of male gametes in relation to oxidative stress

Thursday, March 28, 2013
Proteomic analysis shows that differences in protein expression in spermatozoa producing higher levels of ROS may play a role in the pathophysiology of male infertility.

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The apoptotic pathway in fertile and subfertile men A case control and prospective study to examine the impact of merocyanine 540 bodies on ejaculated spermatozoa

Thursday, March 28, 2013
The presence of merocyanine 540 staining bodies does not affect quantification of early and late apoptotic biomarkers in spermatozoa from fertile and subfertile men.

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