Decreased expression of microRNA 29 family in leiomyoma contributes to increased major fibrillar collagen production

Monday, May 2, 2016

Authors:
Erica E. Marsh, M.D., M.S.C.I., Marissa L.…

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Epidermal growth factor containing fibulin like extracellular matrix protein 1 EFEMP1 expression and regulation in uterine leiomyoma

Friday, April 1, 2016
Epidermal growth factor–containing fibulin-like extracellular matrix protein 1 gene expression and fibulin- 3 protein expression are significantly down-regulated in leiomyomas versus myometrium in vivo and in vitro. Differences in expression are partially due to differences in methylation status.

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Evaluation of the antiproliferative proapoptotic and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma

Monday, February 1, 2016
Polyinosinic-polycytidylic acid complexed with polyethylenimine clearly decreased angiogenesis and promoted apoptosis in a mouse model of leiomyoma, but prolonged treatments may be necessary to affect lesion size.

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Mechanisms underlying aberrant expression of miR 29c in uterine leiomyoma

Tuesday, December 29, 2015
Expression of miR-29c is suppressed and inversely correlated with collagen and DNMT3A in leiomyoma. The suppression of miR-29c in leiomyoma smooth muscle cells is primarily mediated by specific protein 1, NF-kB signaling, and epigenetic modification.

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Effect of menses on standardized assessment of sexual dysfunction among women with uterine fibroids A cohort study

Thursday, July 30, 2015
Women with uterine fibroids report differences in specific domains on a validated measure of sexual functioning during menses vs. between menses.

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Leiomyoma derived transforming growth factor β impairs bone morphogenetic protein 2 mediated endometrial receptivity

Friday, February 27, 2015
Fibroid-derived TGF-b3 alters endometrial BMP-2 signaling and prevents up-regulation of HOXA10 and leukemia inhibitory factor. The TGF-b blockade restoresBMP-2 stimulation ofHOXA10 and leukemia inhibitory factor andmay improve endometrial receptivity.

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Acute torsion of uterine remnant leiomyoma with Mayer Rokitansky Küster Hauser syndrome

Wednesday, July 30, 2014
Elective surgical intervention for women with Mayer- Rokitansky-K€uster-Hauser syndrome and uterine remnant leiomyomas can prevent the complication of torsion as well as prevent ovarian resection in premenopausal women.

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Liarozole inhibits transforming growth factor β3 mediated extracellular matrix formation in human three dimensional leiomyoma cultures

Wednesday, June 25, 2014
Leiomyoma and myometrial cells in three-dimensional leiomyoma cultures treated with liarozole resulted in decreased expression of transforming growth factor b3 (TGF-b3) and TGF-b3-regulated extracellular matrix.

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Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

Wednesday, April 30, 2014
Small molecules that specifically inhibit the canonical WNT/b-catenin pathway attenuate growth and proliferation of human uterine leiomyoma cell primary cultures.

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Nonobese diabetic severecombined immunodeficient murine xenograft model for human uterine leiomyoma

Wednesday, April 30, 2014
We established a novel NOD/SCID murine xenograft model for uterine leiomyoma that reproduced histologic characteristics, sex steroid–dependent growth, and specific gene expression profiles of the original leiomyoma tissue.

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Vaginal mifepristone for the treatment of symptomatic uterine leiomyomata An open label study

Friday, January 31, 2014
Vaginal mifepristone may offer an effective treatment option for women with symptomatic uterine leiomyomas and can improve the patients’ quality of life.

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Effects of mifepristone on uterine leiomyoma in premenopausal women a meta analysis

Wednesday, November 27, 2013
Mifepristone was effective in treating leiomyomas, and 2.5 mg of mifepristone administered daily for 3 or 6 months was the optimal dosage for leiomyoma treatment.

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Biomarkers in uterine leiomyoma

Monday, March 18, 2013
The biomarkers, biologic compounds that are easily accessible and reflect normal physiology or pathology, studied in uterine leiomyomas are currently not clinically useful.

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Gonadotropin releasing hormone GnRH agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production

Thursday, November 1, 2012
Gonadotropin-releasing hormone analogues leuprolide acetate and cetrorelix acetate directly regulate extracellular matrix components COL1A1, fibronectin, and versican in human uterine leiomyoma cells relative to patient-matched myometrial cells.

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New Science Will Move Fibroid Therapies Into the 21st Century

Tuesday, June 12, 2012

Author:
Elizabeth A. Stewart, M.D.…

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Identification and Characterization of the Human Leiomyoma Side Population as Putative Tumor-Initiating Cells

Friday, June 8, 2012
The side population method was used to isolate and identify putative tumor-initiating leiomyoma stem cells as demonstrated by their ability to differentiate in vitro and reconstruct leiomyoma tissue in vivo.

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Roles of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas

Thursday, June 7, 2012
PDCD-4 is unexpectedly elevated in leiomyomas, but normal myometrium does not express the protein; the expected inverse correlation of microRNA-21 and its target PDCD-4 is absent in fibroids.

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Adverse obstetric outcomes associated with sonographically identified large uterine fibroids

Friday, June 1, 2012
Women with large uterine fibroids delivered at an earlier gestational age compared to women with small or no fibroids. Blood loss and rate of blood transfusion were also increased.

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Recombinant H2 relaxin inhibits apoptosis and induces cell proliferation in cultured leiomyoma cells without affecting those in cultured normal myometrial cells

Wednesday, May 23, 2012
Human relaxin selectively inhibits apoptosis by downregulating caspase-3 expression and induces proliferation in cultured human leiomyoma cells without affecting apoptosis or proliferation in normal myometrial cells.

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