The high prevalence of diabetes in Klinefelter patients is possibly due to abnormal karyotypes. Other risk factors, such as low T and high triglyceride, may also contribute to the development of diabetes.
More knowledge about the development of the androgenic and spermatogenic compartments of the Klinefelter testis is needed to formulate a rational approach to fertility optimization and preservation in these men.
The impact of early hormone therapy on fertility outcomes in patients with Klinefelter syndrome is not well understood. Semen or testicular tissue cryopreservation should be considered in affected adolescents to maximize future fertility potential.
This collection of articles written by a series of experts should help all those who deal with Klinefelter syndrome patients develop a much broader and scientifically based understanding of this common condition.
We performed a literature review of the genetic etiology of Klinefelter syndrome, its effect on spermatogenesis, and the health of children born from men with Klinefelter syndrome following assisted reproductive technology.
To date, retrieval of spermatogonial cells in prepubertal boys with Klinefelter syndrome should be viewed as experimental and patients and their parents must be counseled accordingly.
Although their testes showed severe fibrosis and hyalinization, spermatogonia were observed in 4 of 22 Klinefelter syndrome patients with no sperm recovered after TESE.
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