Are we ready to eliminate the transfer of fresh embyos in in vitro fertilization

Wednesday, June 25, 2014
The rationale to freeze all embryos to avoid transfer into a supraphysiologic environment to improve safety and efficacy is compelling, but not yet proven. How do we decide?

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Cryopreservation of human embryos and its contribution to in vitro fertilization success rates

Wednesday, June 25, 2014
The success rates after frozen-thawed embryo transfer are nearing those of fresh transfer in assisted reproductive technology cycles. Randomized controlled trials should determine whether fresh transfers should be abandoned.

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X chromosome inactivation in female newborns conceived by assisted reproductive technologies

Sunday, June 1, 2014
X-chromosome inactivation in female newborns is not affected by intracytoplasmic sperm injection or in vitro fertilization.

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Is the modified natural in vitro fertilization cycle justified in patients with genuine poor response to controlled ovarian hyperstimulation

Sunday, June 1, 2014
Modified natural cycles is of no benefit for "genuine" poor ovarian responders and the option of egg donation should be seriously considered for this population.

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Use of fertility treatment modalities in a large United States cohort of professional women

Sunday, June 1, 2014
Approximately 94% of women using fertility treatment used clomiphene, with smaller proportions using gonadotropin alone, intrauterine insemination, and in vitro fertilization. These patterns varied by financial, biologic, and temporal factors.

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Maternal and neonatal outcomes after gonadotropin releasing hormone agonist trigger for final oocyte maturation in patients undergoing in vitro fertilization

Tuesday, May 20, 2014
Gonadotropin-releasing hormone agonist trigger does not affect obstetrical or neonatal outcomes in antagonist cycles.

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Stimulation of mitochondrial embryo metabolism by dichloroacetic acid in an aged mouse model improves embryo development and viability

Wednesday, April 30, 2014
Stimulation of mitochondria in embryos from older mice improved embryo viability and fetal weights and therefore may be a novel means of improving outcomes in an IVF setting.

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Effect of oocyte donation on pregnancy outcomes in in vitro fertilization twin gestations

Wednesday, April 30, 2014
In patients who conceive twin pregnancies using IVF, oocyte donation increases the risk of gestational hypertension and preeclampsia.

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Effects of assisted reproductive technologies on human sex ratio at birth

Wednesday, April 30, 2014
The authors analyzed the gender of more than 100,000 babies in the United Kingdom born after ART and found that the type of ART treatment used can affect the sex ratio.

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Human embryos secrete microRNAs into culture media a potential biomarker for implantation

Wednesday, April 30, 2014
Human blastocysts secrete microRNAs into culture media, and MicroRNAs may be a noninvasive marker for delivery after in vitro fertilization.

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The Affordable Care Act early implications for fertility medicine

Wednesday, April 30, 2014
With the majority of the Patient Protection and Affordable Care Act (ACA) taking effect in 2014, insurers, patients, and healthcare providers in every field of medicine await the law's full impact.

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Value of antimüllerian hormone as a prognostic indicator of in vitro fertilization outcome

Monday, March 31, 2014
Antimüllerian hormone is highly correlated with number of eggs retrieved. Very low levels are associated with diminished yet reasonable pregnancy rates, mediated through number of oocytes retrieved as opposed to oocyte quality.

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Ovarian endometriomas and oocyte quality insights from in vitro fertilization cycles

Monday, March 31, 2014
In women with unilateral unoperated endometriomas undergoing IVF, ovarian responsiveness and oocyte developmental competence did not differ between the affected and intact gonads.

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Preventing ovarian hyperstimulation with gonadotropin releasing hormone agonist trigger Is anything perfect

Monday, March 31, 2014
Reflections on "Severe ovarian hyperstimulation syndrome after gonadotropin-releasing hormone (GnRH) agonist trigger and “freeze-all” approach in GnRH antagonist protocol" by Fatemi et al.

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A randomized clinical trial of endometrial perfusion with granulocyte colony stimulating factor in in vitro fertilization cycles Impact on endometrial thickness and clinical pregnancy rates

Thursday, February 20, 2014
Granulocyte colony-stimulating factor neither affects endometrial thickness nor pregnancy rates in normal in vitro fertilization patients.

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Rescue intracytoplasmic sperm injection A systematic review

Thursday, February 20, 2014
A literature search using the term “rescue ICSI” was performed. Thirty-eight studies were included, describing 1,863 patients and 194 offspring. Pregnancy rates and procedure safety are discussed.

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The nature of aneuploidy with increasing age of the female partner a review of 15169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening

Thursday, February 20, 2014
The lowest aneuploidy risk is between ages 26–30, with higher prevalences inyoungerandolderwomen, and 67% involve a single chromosome,with the ratio of trisomies/monosomies approximating 1.

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Methotrexate treatment of ectopic pregnancies does not affect ovarian reserve in in vitro fertilization patients

Friday, January 31, 2014
Reflections on "Ovarian reserve and subsequent assisted reproduction outcomes after methotrexate therapy for ectopic pregnancy or pregnancy of unknown location by Hill et al.

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Sex related growth differences are present but not enhanced in in vitro fertilization pregnancies

Friday, January 31, 2014
In vitro fertilization does not enhance sex-specific differences in fetal growth.

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In vitro fertilization on the front line beginning infertility or gonadotropin treatments with in vitro fertilization

Friday, January 31, 2014
In this editorial the authors discuss the use of IVF and gonadotropin treatment on a broader scale and also as a first-line treatment.

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Bowel complications of deep endometriosis during pregnancy or in vitro fertilization

Friday, January 31, 2014
This study examines bowel complications caused by the progression of deep endometriosis during pregnancy or IVF. Endometriosis prevalence and its complications in pregnancy are unknown because the association is probably underreported.

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Slightly lower incidence of ectopic pregnancies in frozen embryo transfer cycles versus fresh in vitro fertilization embryo transfer cycles A retrospective cohort study

Tuesday, December 31, 2013
In a retrospective analysis a slightly, but not significant, lower incidence of ectopic pregnancies was found in frozen ET cycles than in fresh IVF ET cycles.

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Impact of antimullerian hormone assays on the outcomes of in vitro fertilization a prospective controlled study

Tuesday, December 31, 2013
The AMH assays reduced the cancellation rate after ovarian stimulation and helped some patients not to begin IVF stimulation because of their low AMH level.

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Could safety boards provide a valuable tool to enhance the safety of reproductive medicine

Wednesday, November 27, 2013
The National Transportation Safety Board provides an excellent model for a safety program that could enhance safety in the practice of all aspects of reproductive medicine.

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Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of blastocyst stage versus cleavage stage embryos generated through in vitro fertilization treatment A systematic review and meta analysis

Wednesday, November 27, 2013
Singleton pregnancies arising from the transfer of embryos at blastocyst-stage in IVF appear to have higher risk of preterm and very preterm delivery when compared with cleavage-stage transfer.

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Access to fertility treatment by gays lesbians and unmarried persons a committee opinion

Wednesday, November 27, 2013
This statement explores the implications of reproduction by single individuals, unmarried heterosexual couples, and gay and lesbian couples.

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Experience with ISO quality control in assisted reproductive technology

Wednesday, November 27, 2013
ISO 9001 is a quality management system, the benefits of which include improved focus on customers, organizational improvement, as well as control of documents, greater efficiency, and mechanisms to allow for continual improvement.

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Detection of oncogenic human papillomavirus genotypes on spermatozoa from male partners of infertile couples

Thursday, October 31, 2013
Standard sperm evaluation, human papillomavirus (HPV) DNA detection, and in situ hybridization analysis were performed in 308 patients undergoing IVF procedures. Oncogenic HPV genotypes were detected on spermatozoa from asymptomatic subjects.

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Does culture medium influence offspring birth weight

Thursday, October 31, 2013
After analyzing the influence of different embryo culture media on the weight of the newborn, the results do not show any relationship between them.

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Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates a randomized controlled trial

Friday, August 30, 2013
A randomized controlled trial demonstrates that blastocyst biopsy followed by rapid quantitative real-time polymerase chain reaction–based comprehensive chromosome screening and fresh embryo transfer significantly increases implantation and delivery rates.

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