Gonadotropin releasing hormone agonist trigger in clinical in vitro fertilization Can the suboptimal candidate be defined?

Tuesday, September 1, 2015
Reflections on "Risk factors for a suboptimal response to gonadotropin-releasing hormone agonist trigger during in vitro fertilization cycles" by Meyer et al.

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Risk factors for a suboptimal response to gonadotropin releasing hormone agonist trigger during in vitro fertilization cycles

Tuesday, September 1, 2015
Risk factors for suboptimal response to gonadotropin-releasing hormone agonist-agonist trigger include low luteinizing hormone (LH) and follicle stimulating hormone on in vitro fertilization cycle start day, low LH on trigger day, history of irregular menses, and long-term oral contraceptive use.

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Mild ovarian stimulation with clomiphene citrate launch is a realistic option for in vitro fertilization

Thursday, July 30, 2015
Mild stimulation using clomiphene citrate can be considered a realistic option to give patients with a good prognosis an excellent probability of pregnancy in a very short time period.

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Exploratory randomized trial on the effect of a brief psychological intervention on emotions, quality of life discontinuation and pregnancy rates in in vitro fertilization patients

Thursday, July 30, 2015
A combined cognitive coping and relaxation self help psychological intervention was associated with improved psychological status but not lower treatment discontinuation or higher pregnancy rates.

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Personalized prediction of live birth Are we there yet

Thursday, July 30, 2015

Authors:
David B. Seifer, M.D., Reshef Tal, M.D., Ph.D.…

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Autologous endometrial coculture biopsy Is timing everything

Monday, June 29, 2015
Coculture biopsy in the cycle preceding IVF does not increase implantation, clinical pregnancy, or live birth rates compared with biopsies performed more than one cycle before IVF.

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Effect of seminal leukocytes on in vitro fertilization and intracytoplasmic sperm injection outcomes

Monday, June 29, 2015
Leukocytospermia (1  106 leukocytes/mL), assessed by flow cytometry, does not significantly influence IVF or ICSI outcomes. The same results were obtained by using lower or higher cut-off values for leukocytospermia (from 0.2 to 2  106/mL).

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Are good patient and embryo characteristics protective against the negative effect of elevated progesterone level on the day of oocyte maturation

Monday, June 1, 2015
Elevated P level on the day of human chorionic gonadotropin administration negatively affects live-birth rate, regardless of embryo stage, embryo quality, patient age, or ovarian response.

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Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells

Monday, June 1, 2015
We discuss how poor response to controlled ovarian hyperstimulation in in vitro fertilization is associated with altered microRNA expression in cumulus cells.

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Neonatal outcomes after early rescue intracytoplasmic sperm injection An analysis of a 5 year period

Monday, June 1, 2015
Early rescue intracytoplasmic sperm injection can result in a similar rate of clinical pregnancies when compared with conventional in vitro fertilization/intracytoplasmic sperm injection, as well as delivery of healthy newborns.

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Cryopreserved embryo transfer is an independent risk factor for placenta accreta

Wednesday, April 29, 2015
Cryopreserved embryo transfer is a strong predictor of placenta accreta among patients using in vitro fertilization and/or intracytoplasmic sperm injection. This increased risk may be associated with the thinner endometrial linings and lower estradiol levels characteristic of these cycles.

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Major drawbacks and additional benefits of agonist trigger Not ovarian hyperstimulation syndrome related

Monday, March 30, 2015
High responders and oocyte donors may now be stimulated and triggered with reasonable safety. This paradigm shift confers certain advantages and potential new risks.

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Progesterone to follicle index is better correlated with in vitro fertilization cycle outcome than blood progesterone level

Friday, February 27, 2015
The progesterone-to-follicle index has a linear and inverse relationship to cycle outcome, unlike blood progesterone, which is detrimental only at high levels.

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Frozen thawed day 5 blastocyst transfer is associated with a lower risk of ectopic pregnancy than day 3 transfer and fresh transfer

Friday, February 27, 2015
Frozen-thawed day 5 blastocyst transfer is associated with a lower ectopic pregnancy rate than frozen- thawed day 3 transfer and fresh transfer in patients undergoing IVF-ET.

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Blastocyst transfer is not associated with increased rates of monozygotic twins when controlling for embryo cohort quality

Monday, December 29, 2014
The association between blastocyst transfer and monozygotic twinning may be related to the high quality nature of the embryo cohort rather than the extended culture.

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Liability for mismanagement of sperm specimens in fertility practices

Monday, December 29, 2014

Authors:
Micah Vaughn, B.S., Amjad Hossain, Ph.D., John Y.…

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Status of sperm morphology assessment An evaluation of methodology and clinical value

Monday, December 29, 2014
Morphology levels in sperm assessments decreased over time, owing to changes in methodological factors, and male aging. No prognostic value was found for individual in vitro fertilization or intracytoplasmic sperm injection patients.

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Assessment of follicular fluid leptin levels and insulin resistance as outcome predictors in women undergoing in vitro fertilization intracytoplasmic sperm injection

Tuesday, November 25, 2014
High follicular fluid leptin levels were associated with a lower probability of live birth in women undergoing in vitro fertilization–intracytoplasmic sperm injection. Serum progesterone, follicle number, and leptin levels seem to predict IVF outcome.

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In vitro fertilization versus conversion to intrauterine insemination in Bologna criteria poor responders How to decide which option

Tuesday, November 25, 2014
In vitro fertilization should be preferred in Bologna criteria poor responders with two follicles, because oocyte retrieval is associated with a higher live birth rate compared with conversion to intrauterine insemination.

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How do we decide how many embryos are safe for transfer

Tuesday, November 25, 2014
Reflections on "Beyond the ASRM transfer guidelines: how many cleavage stage embryos are safe to transfer in women > 43 years old?" by Gunnala et al.

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Beyond the American Society for Reproductive Medicine transfer guidelines: how many cleavage stage embryos are safe to transfer in women ≥43 years old

Tuesday, November 25, 2014
Transferring five or more day 3 embryos may be a safe option for patients 43 years of age, and is associated with an overall low rate of multiple gestations.

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Elevated early follicular progesterone levels and in vitro fertilization outcomes A prospective intervention study and meta analysis

Wednesday, July 30, 2014
Elevated progesterone levels on cycle day 2 affect ongoing pregnancy rates in gonadotropin-releasing hormone antagonist cycles.

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Human chorionic gonadotropin versus gonadotropin releasing hormone agonist trigger in assisted reproductive technology The king is dead long live the king

Wednesday, July 30, 2014
In this Conceptions piece, we set out to explore whether current scientific evidence supports the future use of a GnRH-a trigger in all IVF patients co-treated with a GnRH antagonist, regardless of ovarian response on the day of trigger.

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Role of vitamin D in ovarian physiology and its implication in reproduction A systematic review

Wednesday, July 30, 2014
Vitamin D plays an important role in steroidogenesis, follicular development, ovarian reserve measures/markers, and IVF outcome. Vitamin D might have a beneficial reproductive effect in vitamin D–deficient women with polycystic ovary syndrome.

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Role of assisted hatching in in vitro fertilization A guideline

Wednesday, July 30, 2014
This guideline document reviews the safety and efficacy of assisted hatching.

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Posthumous reproduction with surplus in vitro fertilization embryos A study exploring users choices

Thursday, July 10, 2014
Although posthumous assisted reproduction (PAR) appears to be acceptable to a majority of IVF users, further research is required on how to ensure that their consent for PAR is well informed.

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Blastocyst euploidy and implantation rates in a young <35 years and old ≥35 years presumed fertile and infertile patient population

Thursday, July 10, 2014
Our data demonstrated no difference in euploid blastocyst rates between presumed fertile and infertile patients. Pregnancy and implantation rates were significantly higher in presumed fertile patients when transferring euploid blastocysts.

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Assisted reproduction policies in Israel A retrospective analysis of in vitro fertilization embryo transfer

Wednesday, July 9, 2014
The policy of limitless nondonor in vitro fertilization– embryo transfer cycles in Israel should be questioned and further assessed.

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Prospective study of depression and anxiety in female fertility preservation and infertility patients

Tuesday, July 8, 2014
Fertility preservation patients report higher levels of depression and anxiety at the onset of treatment than infertility patients, but infertility patients’ symptoms worsen across treatment.

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Diminished ovarian reserve is the predominant risk factor for gonadotropin releasing hormone antagonist failure resulting in breakthrough luteinizing hormone surges in in vitro fertilization cycles

Wednesday, June 25, 2014
Patients who fail to remain suppressed in response to GnRH antagonists have significantly poorer ovarian reserve compared with patients who do not experience breakthrough LH surges.

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