Higher PDCD4 expression is associated with obesity insulin resistance lipid metabolism disorders and granulosa cell apoptosis in polycystic ovary syndrome

Sunday, May 1, 2016
In polycystic ovary syndrome (PCOS), higher PDCD4 expression promotes obesity, insulin resistance, lipid metabolism disorders, and induced granulosa cell apoptosis, which is an independent risk factor for PCOS.

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Vigorous exercise is associated with superior metabolic profiles in polycystic ovary syndrome independent of total exercise expenditure

Monday, February 1, 2016
Vigorous exercise is associated with superior health profiles and reduced odds of metabolic syndrome in polycystic ovary syndrome, independent of age, body mass index, or total exercise expenditure.

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Cross sectional study of factors influencing sex hormone binding globulin concentrations in normally cycling premenopausal women

Monday, November 30, 2015
In normally cycling premenopausal women, SHBG concentrations, independently from other parameters, are negatively associated with bioavailable T and positively associated with adiponectin.

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Putative role for insulin resistance in depression risk in polycystic ovary syndrome

Tuesday, September 1, 2015
Insulin resistance was found to be linked to depression risk, after controlling for potential confounders, in women who have polycystic ovary syndrome.

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Influence of adrenal hyperandrogenism on the clinical and metabolic phenotype of women with polycystic ovary syndrome

Friday, February 27, 2015
The presence of adrenal hyperandrogenism in women with polycystic ovary syndrome is associated with reduced insulin sensitivity and increased blood pressure, but may have a beneficial impact on the lipid profile.

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Off label drug use in the treatment of polycystic ovary syndrome

Friday, February 27, 2015
This review explores the off-label use of medications used to manage aspects of polycystic ovary syndrome, including androgen excess, irregular menses, and metabolic changes.

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Assessment of follicular fluid leptin levels and insulin resistance as outcome predictors in women undergoing in vitro fertilization intracytoplasmic sperm injection

Tuesday, November 25, 2014
High follicular fluid leptin levels were associated with a lower probability of live birth in women undergoing in vitro fertilization–intracytoplasmic sperm injection. Serum progesterone, follicle number, and leptin levels seem to predict IVF outcome.

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Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes

Wednesday, July 30, 2014
The ability of murine ovarian hormone synthesis became abnormal and the ovarian tissue behaved insulin resistance, after treated with dexamethasone, in vivo and in vitro; the Chinese herbal extract cryptotanshinone was found to partially antagonize their behavior.

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Assessment of insulin resistance in lean women with polycystic ovary syndrome

Wednesday, June 25, 2014
In primary prevention practice, HOMA-M120 and Sib (Avignon et al.) seem to adequately replace the euglycemic-hyperinsulinemic clamp in lean and overweight/obese PCOS patients, respectively.

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Association of abdominal obesity insulin resistance and oxidative stress in adipose tissue in women with polycystic ovary syndrome

Tuesday, June 17, 2014
The strong correlation of insulin resistance and oxidative stress at the visceral adipose tissue level suggests that local oxidative stress and abnormalities of insulin signaling in the adipose tissue play critical roles in polycystic ovary syndrome insulin resistance.

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High dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome A randomized controlled pilot trial

Sunday, June 1, 2014
In a randomized, placebo-controlled trial of vitamin D in PCOS, insulin sensitivity was unchanged, but there was a trend toward decreased 2-hour insulin and a protective effect on blood pressure.

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Insulin resistance and its relationship with high molecule weight adiponectin in adolescents with polycystic ovary syndrome and a maternal history

Tuesday, May 20, 2014
Normal weight adolescents with PCOS and a maternal history of PCOS had a significantly increased rate of insulin resistance independent of body mass index and inversely correlated with high molecular weight adiponectin.

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The type 2 deiodinase Thr92Ala polymorphism is associated with disrupted placental activity but not with dysglycemia or adverse gestational outcomes A genetic association study

Thursday, February 20, 2014
Patients with type 2 deiodinase (D2) Ala92Ala genotype, associated with an increased risk for diabetes, have decreased placental D2 activity that is not associated with dysglycemia or adverse gestational outcomes.

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The Pregnancy in Polycystic Ovary Syndrome Study II baseline characteristics and effects of obesity from a multicenter randomized clinical trial

Tuesday, December 31, 2013
Baseline characteristics from 750 women with PCOS and their male partners from a multicenter trial show the groups to be well matched with body mass index exacerbating metabolic and reproductive parameters.

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Dietary glycemic index is associated with less favorable anthropometric and metabolic profiles women with different phenotypes

Monday, September 30, 2013
Dietary glycemic index is increased in the classic polycystic ovary syndrome (PCOS) phenotype and associated with less favorable anthropometric and metabolic profiles. Obesity and classic PCOS phenotype are predictors of higher dietary glycemic index.

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Functional neuroimaging of emotional processing in women with polycystic ovary syndrome a case control pilot study

Friday, June 28, 2013
Functional magnetic resonance imaging of limbic activation with emotional processing differed between healthy women and women with insulinresistant polycystic ovary syndrome.

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Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood

Friday, June 28, 2013
In utero testosterone excess, together with gestational hyperglycemia, may contribute to ontogeny of polycystic ovary syndrome (PCOS). Lifestyle or therapeutic intervention during pregnancy or childhood may alleviate familial genetic predisposition to PCOS.

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Subclinical hypothyroidism in young women with polycystic ovary syndrome An analysis of clinical hormonal and metabolic parameters

Monday, February 4, 2013
Young women with polycystic ovary syndrome and subclinical hypothyroidism present higher serum levels of low-density lipoprotein cholesterol with no changes in other lipid profile parameters, insulin resistance, or phenotypic manifestations.

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Adipose tissue insulin resistance in peripubertal girls with first degree family history of polycystic ovary syndrome

Thursday, November 29, 2012
Girls at risk for PCOS are mainly characterized by insulin resistance and resistance to insulin-induced lipolysis suppression. Predisposition to PCOS may thus be related to adipocyte dysfunction.

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Adipose expression of adipocytokines in women with polycystic ovary syndrome

Thursday, June 7, 2012
In a cross-sectional study of women with and without polycystic ovary syndrome (PCOS), obesity but not PCOS affected the expression of adipose expression and plasma levels of adipocytokines.

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Circulating Vitamin D Correlates with Serum Anti-Mullerian Hormone Levels in Late Reproductive-Aged Women: Women’s Interagency HIV Study

Thursday, June 7, 2012
Serum 25-hydroxyvitamin D levels are positively correlated with serum antim€ullerian hormone levels in latereproductive-aged women (40 years old).

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Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

Thursday, May 31, 2012
The third polycystic ovary syndrome (PCOS) consensus report summarizes current knowledge and identifies knowledge gaps regarding various women’s health aspects of PCOS.

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Should all women with PCOS be treated for insulin resistance?

Thursday, May 31, 2012
Insulin resistance of variable severity is commonly present in women with PCOS. Arguments and rationale are presented for treating all or only selected women with insulin sensitizing drugs.

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Effects of acupuncture and exercise on insulin sensitivity, adipose tissue characteristics, and markers of coagulation and fibrinolysis in women with polycystic ovary syndrome: secondary analyses of a randomized controlled trial

Thursday, May 31, 2012
We studied the effect of acupuncture and exercise on hemostatic factors, insulin sensitivity, and adipose tissue characteristics in PCOS. Acupuncture counteracted a possible prothrombotic state in women with PCOS as reflected by decreased plasminogen activator inhibitor activity.

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Cross-sectional analysis of the effects of age on the hormonal, metabolic, and ultrasonographic features and the prevalence of the different phenotypes of polycystic ovary syndrome

Thursday, May 31, 2012
In women with PCOS, hyperandrogenemia appears to diminish during reproductive life whereas insulin resistance persists. This progressive worsening of insulin resistance is primarily driven by the increase in obesity.

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Risk of obstructive sleep apnea in obese and nonobese women with polycystic ovary syndrome and healthy reproductively normal women

Thursday, May 24, 2012
The increased risk for obstructive sleep apnea (OSA) in PCOS may be related to obesity. Nonobese women with PCOS are not at increased risk for OSA compared with control women with similar body mass indexes.

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Metabolic manifestations of polycystic ovary syndrome in nonobese adolescents: retinol-binding protein 4 and ectopic fat deposition

Friday, May 11, 2012
Adolescents with PCOS had higher intrahepatic lipid content and a statistical trend for higher retinol-binding protein 4 (RBP4) levels than controls. There may be an independent relationship between RBP4 and triglycerides.

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