Estrogen receptor β regulates endometriotic cell survival through serum and glucocorticoid regulated kinase activation

Sunday, May 1, 2016
Estrogen receptor (ER) b is aberrantly overexpressed in ectopic endometriotic tissues. This study demonstrates that ERb regulates the transcription of SGK1, a kinase that promotes apoptotic resistance in endometriosis via FOXO3 inactivation.

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Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients

Friday, April 1, 2016
Excising endometriotic lesions significantly decreased circulating levels of inflammatory cytokines. Levels were also higher than in normal women, dissimilar in eutopic versus ectopic endometrium, and influenced by disease stage.

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The maternal microbiome and pregnancy outcomes

Monday, November 30, 2015
Metagenomic research has begun to reveal the complex interaction between the gravid microbiome, maternal genetic polymorphisms, and spontaneous preterm birth.

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Antioxidant properties of high density lipoproteins are impaired in women with polycystic ovary syndrome

Wednesday, April 29, 2015
The antioxidant/anti-inflammatory function of HDL was impaired in PCOS. High-density lipoprotein dysfunction is related to hyperandrogenism status, increased oxidative stress, and abnormalities in HDL components.

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Preeclampsia is associated with a deficiency of lipoxin A4 An endogenous anti inflammatory mediator

Wednesday, June 25, 2014
Lipoxin A4 deficiency may result in preeclampsia because of changes in inflammation, oxidative stress, and 11b-HSD2 expression.

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Sperm proteomics Fertility diagnostic testing beyond the semen analysis

Sunday, June 1, 2014
Reflections on "Acute epididymitis induces alterations in sperm protein composition" by Pilatz et al.

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Urinary cytokine and chemokine profiles across the menstrual cycle in healthy reproductive age women

Wednesday, April 30, 2014
Using longitudinal data on menstrual cycle function, we evaluated urinary cytokines levels for assessment of reproductive function by considering detection, variation across the menstrual cycle, and correlations with hormones.

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Ovarian endometriosis The nemesis of eggs

Monday, March 31, 2014
Reflections on "Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas" by Kitajima et al.

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Pathogenesis consequences and control of peritoneal adhesions in gynecologic surgery a committee opinion

Tuesday, April 30, 2013
Postoperative adhesions are a natural consequence of tissue trauma and healing; however, adherence to microsurgical principles and minimally invasive surgery may help to reduce postoperative adhesions.

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Dietary Fish Oil Supplementation Inhibits Formation of Endometriosis-Associated Adhesions in a Chimeric Mouse Model

Monday, February 4, 2013
In an established model of spontaneous adhesive disease associatedwith experimental human endometriosis in nude mice, development of adhesions was significantly reduced in animals provided with an antiinflammatory diet containing fish oil.

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Interleukin 19 and Interleukin 22 serum levels are decreased in ovarian endometrioma

Wednesday, January 2, 2013
Serum interleukin-19 and -22 are decreased in ovarian endometrioma. They may be involved in the pathogenesis of endometriosis.

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Interleukin 17A is present in neutrophils in endometrioma and stimulates the secretion of growth related oncogene α Gro α from endometrioma stromal cells

Thursday, November 1, 2012
Interleukin (IL)-17A was present in neutrophils in endometrioma and it increased Gro-a secretion from endometrioma stromal cells, which induced neutrophil migration. IL-17A in neutrophils may contribute to the development of endometriosis.

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Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology

Saturday, September 15, 2012
NF-kB activation upregulates 18 inflammation and cell proliferation and inhibits apoptosis of 19 endometriotic cells. Iron overload-mediated NF-kB activation is postulated as a mechanism 20 favoring endometriosis development.

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Inflammation: a link between endometriosis and preterm birth

Wednesday, June 6, 2012
Inflammatory events are involved in the pathogenesis of endometriosis and preterm birth, and a clinical correlation is suggested.

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Is PCOS an inflammatory process?

Thursday, May 31, 2012
While the etiology of PCOS remains a mystery, the evidence in support of the presence of chronic lowgrade inflammation in women with this syndrome is emerging.

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