Assisted reproductive technology and somatic morbidity in childhood A systematic review

Friday, February 27, 2015
The literature indicates that children conceived by assisted reproductive technology may be at increased risk of somatic morbidity in childhood compared with spontaneously conceived children.

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In vitro development of donated frozen thawed human embryos in a prototype static microfluidic device A randomized controlled trial

Friday, February 27, 2015
This study shows that a microfluidic device tested under static conditions supports single-embryo culture of donated frozen-thawed human day-4 embryos to advanced blastocyst stages.

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Live birth in a 50 year old woman following in vitro fertilization embryo transfer with autologous oocytes A rare case report

Friday, January 30, 2015
A 50-year-old woman conceived with her own oocytes by means of in vitro fertilization and successfully delivered a healthy male baby by cesarean section.

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Birth weight is associated with inner cell mass grade of blastocysts

Friday, January 30, 2015

Capsule:
Blastocysts with a more developed inner cell mass developed into newborns with a greater weight, when corrected for gestational age and gender.…

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Effect of male and female body mass index on pregnancy and live birth success after in vitro fertilization

Friday, January 30, 2015
No association between male and female BMI, individually or combined, and IVF success was found after accounting for important confounding factors, including male and female age, partner BMI, and parity.

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Building a family through in vitro fertilization Economic realities

Friday, January 30, 2015
Reflections on "The Great Recession, insurance mandates, and the utilization of in vitro fertilization services in the United States" by Kiatpongsan et al.

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Metaanalysis of estradiol for luteal phase support in in vitro fertilization intracytoplasmic sperm injection

Friday, January 30, 2015
This meta-analysis suggests that estradiol addition during the luteal phase does not improve in vitro fertilization/intracytoplasmic sperm injection outcomes through oral medication, even with different daily doses.

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The Great Recession insurance mandates and the use of in vitro fertilization services in the United States

Friday, January 30, 2015
There is a positive relationship between the economy and in vitro fertilization use in the United States, and this relationship is significantly stronger in states with insurance mandates.

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Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during oocyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization

Monday, December 29, 2014
We discuss how follicular fluid cortisol levels may regulate cumulus cell lipolysis during oocyte meiotic resumption and affect oocyte quality during in vitro fertilization.

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Prolonging oocyte in vitro culture and handling time does not compensate for a shorter interval from human chorionic gonadotropin administration to oocyte pickup

Monday, December 29, 2014
Delaying oocyte denudation or injection does not compensate for a suboptimal in vivo exposure to the follicular environment.

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Progesterone elevation on the day of human chorionic gonadotropin administration is not the only factor determining outcomes of in vitro fertilization

Monday, December 29, 2014
The elevated progesterone on the day of human chorionic gonadotropin triggering has an obvious negative impact on pregnancy outcome only at extremely high progesterone concentrations.

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Timing of oviductal fluid collection steroid concentrations and sperm preservation method affect porcine in vitro fertilization efficiency

Tuesday, November 25, 2014

Capsule:
Changes in steroid concentrations during the reproductive cycle are delayed in oviductal fluid (OF) compared with serum.…

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Developmental potential of zona pellucida free oocytes obtained following mild in vitro fertilization

Tuesday, November 25, 2014
Zona pellucia–free eggs could be cultured until the blastocyst stage with efficacy similar to zona intact control eggs, without adversely affecting pregnancy rates and the neonatal outcome of resulting offspring.

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Efficacy and safety of intrauterine insemination and assisted reproductive technology in populations serodiscordant for human immunodeficiency virus A systematic review and meta analysis

Wednesday, July 30, 2014
A systematic review and meta-analysis for outcomes with intrauterine insemination and in vitro fertilization for HIV-serodiscordant couples found no seroconversions and similar outcomes to HIV-seronegative infertility patients.

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Association between infertility treatment and symptoms of postpartum depression

Tuesday, July 22, 2014
In a population-based sample, infertility treatment as recorded on the birth certificate was not associated with symptoms of postpartum depression.

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Female cystic fibrosis mutation carriers and assisted reproductive technology Does carrier status affect reproductive outcomes

Monday, July 14, 2014
Female cystic fibrosis (CF) carrier status does not appear to impact the chance of achieving pregnancy with assisted reproductive technology (ART). Further research is needed to investigate whether positive CF carrier status affects fertility in a non-ART context.

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When is clomiphene or gonadotropin intrauterine insemination futile Results of the Fast Track and Standard Treatment Trial and the Forty and Over Treatment Trial two prospective randomized controlled trials

Tuesday, July 8, 2014
Controlled ovarian hyperstimulation with intrauterine insemination may be futile for infertile couples of any age with follicle stimulating hormone levels of 10–15 mIU/mL and estradiol 40 pg/mL.

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Why we should transfer frozen instead of fresh embryos The translational rationale

Wednesday, June 25, 2014
Frozen transfer allows embryos to implant and develop in a more physiologic environment. This review summarizes the research on the effect of the superovulated environment on implantation and embryo development.

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Does prolonged pituitary down regulation with gonadotrophin releasing hormone agonist increase live birth rate in in vitro fertilization treatment?

Wednesday, June 25, 2014
In a comparison of the regular long protocol with a prolonged protocol with 28-days’ down-regulation, a significantly higher live-birth rate (55.56%vs. 45.73%) was observed with the prolonged protocol.

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A randomized controlled pilot trial on the effect of dehydroepiandrosterone on ovarian response markers ovarian response and in vitro fertilization outcomes in poor responders

Wednesday, June 25, 2014
No significant improvement in ovarian response markers, ovarian response to standard dose gonadotropin stimulation, or IVF outcomes was detected in poor responders receiving pretreatment DHEA compared with placebo.

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Live birth from a 46 year old using fresh autologous oocytes through in vitro fertilization

Wednesday, June 25, 2014
We report a live birth with in vitro fertilization from a 46-year-old woman using autologous oocytes.

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Clinical rationale for cryopreservation of entire embryo cohorts in lieu of fresh transfer

Wednesday, June 25, 2014
Frozen embryo transfer is now competitive with fresh transfer and may be superior in some cases. Numerous factors should be considered when deciding between them.

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Preterm births multiples and fertility treatment Recommendations for changes to policy and clinical practices

Wednesday, June 25, 2014
Each year nearly one in eight infants in the United States is born preterm. Preterm birth places babies at increased risk for death, health problems including long-term neurological disabilities, and extended time in the hospital.

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Incidence of hypertension stroke coronary heart disease, and diabetes in women who have delivered after in vitro fertilization A population based cohort study from Sweden

Monday, June 16, 2014
In a cohort study, the incidence of hypertension increased in women after IVF pregnancies, suggesting that these women could have a propensity to develop cardiovascular disease later in life.

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Assisted hatching Trends and pregnancy outcomes United States 2000 2010

Tuesday, June 10, 2014
Assisted hatching use has increased but is not associated with improved pregnancy outcomes, even in poor prognosis patients. Prospective studies should better assess the potential benefits of assisted hatching.

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Examining the temperature of embryo culture in in vitro fertilization A randomized controlled trial comparing traditional core temperature 37°C to a more physiologic cooler temperature 36°C

Thursday, June 5, 2014
Prior data suggested that tubal temperatures are lower than the IVF culture temperature of 37C. Paired comparison of human embryo culture at 36C and 37C reveals better outcomes at 37C.

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A randomized clinical trial to determine optimal infertility treatment in older couples The forty and over treatment trial

Sunday, June 1, 2014
In older infertile women, treatment initiated with two cycles of CC/IUI or FSH/IUI compared with immediate IVF demonstrated superior pregnancy rates with fewer treatment cycles in the immediate IVF group.

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Oocyte retrieval timing based on spontaneous luteinizing hormone surge during natural cycle in vitro fertilization treatment

Monday, March 31, 2014
In ncIVF treatment OR scheduling based on the occurrence of spontaneous LH surge yields acceptable oocyte recovery, fertilization, and embryo cleavage rates.

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Effect of fibroids not distorting the endometrial cavity on the outcome of in vitro fertilization treatment A retrospective cohort study

Thursday, February 20, 2014
A retrospective cohort study demonstrates that intramural fibroids with diameter larger than 2.85 cm have a negative effect on in vitro fertilization/intracytoplasmic sperm injection delivery rates.

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Unilateral oophorectomy results in compensatory follicular recruitment in the remaining ovary at time of ovarian stimulation for in vitro fertilization

Thursday, February 20, 2014
Women with a prior unilateral oophorectomy have compensatory follicular recruitment in the remaining ovary, and right ovaries respond better than left ovaries after stimulation for IVF.

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