Outcomes of in vitro fertilization with preimplantation genetic diagnosis: an analysis of the Unites States Assisted Reproductive Technology Surveillance Data 2011 2012

Monday, February 1, 2016
Preimplantation genetic diagnosis for aneuploidy screening may be beneficial for reducing the risk of miscarriage in women aged 35 and improving chances of a live birth in women >37 years.

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Gonadotropin releasing hormone agonist trigger in oocyte donors co treated with a gonadotropin releasing hormone antagonist A dose finding study

Monday, February 1, 2016
Comparable numbers of mature oocytes and top quality embryos are retrieved after the use of triptorelin doses of 0.2, 0.3, or 0.4 mg to trigger ovulation in oocyte donors.

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450 IU versus 600 IU gonadotropin for controlled ovarian stimulation in poor responders A randomized controlled trial

Monday, November 30, 2015
Our randomized controlled trial showed poor ovarian response, a microdose GnRH-a flare-up protocol with a daily dose of 600 IU gonadotropin does not significantly increase the number of mature (MII) oocytes compared with 450 IU/d.

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Embryo selection versus natural selection How do outcomes of comprehensive chromosome screening of blastocysts compare with the analysis of products of conception from early pregnancy loss dilation and curettage among an assisted reproductive technology population

Monday, November 30, 2015
This study compares the incidence of numerical chromosomal abnormalities reported after preimplantation genetic screening analysis vs. those reported after cytogenetic analysis of products of conception after spontaneous abortion.

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Effect of male body mass index on live birth sex ratio of singletons after assisted reproduction technology

Monday, November 30, 2015
This study describes an association between male body mass index and the live-birth sex ratio of singletons following IVF or intracytoplasmic sperm injection treatment but a lack of association with likelihood of achieving live birth success.

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Effect of treatment of a previous ectopic pregnancy on in vitro fertilization intracytoplasmic sperm injection outcomes A retrospective cohort study

Monday, November 30, 2015
This retrospective cohort study demonstrates that a history of ectopic pregnancy carries a higher risk of recurrent ectopic pregnancy after in vitro fertilization– intracytoplasmic sperm injection.

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Gonadotropin dose is negatively correlated with live birth rate Analysis of more than 650000 assisted reproductive technology cycles

Thursday, October 29, 2015
Live birth rate decreased with increasing follicle stimulating hormone dose, regardless of number of oocytes retrieved.

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Dynamic antimullerian hormone levels during controlled ovarian hyperstimulation predict in vitro fertilization response and pregnancy outcomes

Thursday, October 29, 2015
The rate of antimullerian hormone decline during controlled ovarian hyperstimulation is associated with ovarian reserve, in vitro fertilization response, and clinical pregnancy, particularly in women older than 35 years of age.

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Influence of different oocyte insemination techniques on early and late morphokinetic parameters Retrospective analysis of 500 time lapse monitored blastocysts

Thursday, October 29, 2015
In vitro fertilization–fertilized embryos developed with a 1.5-hour delay, which disappeared after standardization to pronuclear fading, thus permitting the joint analysis of standard IVF- and ICSI-fertilized embryo cohorts.

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The conversation

Thursday, October 29, 2015
This article provides a summary of the biopsychosocial model and the assessment and treatment of psychologically based male sexual dysfunction as manifested in cases of infertility.

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Randomized controlled pilot trial of natural versus hormone replacement therapy cycles in frozen embryo replacement in vitro fertilization

Tuesday, September 29, 2015
This randomized, controlled trial suggests that, for women with regular ovulatory cycles undergoing frozen embryo replacement in vitro fertilization, the live birth rate is similar whether the endometrium is prepared using a natural menstrual cycle or GnRH-agonist pituitary suppression and hormone replacement therapy.

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Ectopic pregnancy rate increases with the number of retrieved oocytes in autologous in vitro fertilization with non tubal infertility but not donor recipient cycles An analysis of 109140 clinical pregnancies from the Society for Assisted Reproductive Technology registry

Tuesday, September 29, 2015
In autologous in vitro fertilization but not in donor/recipient in vitro fertilization cycles, ectopic pregnancy rates are higher in cycles with a higher number of oocytes retrieved.

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Can highly sensitive antimullerian hormone testing predict failed response to ovarian stimulation

Tuesday, September 1, 2015
Using a cut point of 0.5 ng/mL, antimullerian hormone (AMH) performs well to identify patients at risk of failure of ovarian stimulation for in vitro fertilization. PicoAMH does not provide superior ability to predict failed response.

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Gonadotropin releasing hormone agonist trigger in clinical in vitro fertilization Can the suboptimal candidate be defined?

Tuesday, September 1, 2015
Reflections on "Risk factors for a suboptimal response to gonadotropin-releasing hormone agonist trigger during in vitro fertilization cycles" by Meyer et al.

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Total levels localization patterns and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection

Tuesday, September 1, 2015
Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C Zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection, but not after in vitro fertilization.

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Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome Summary of a Cochrane review

Tuesday, September 1, 2015
We conducted a systematic review of the use of metformin as a cotreatment during in vitro fertilization and during intracytoplasmic sperm injection in women with polycystic ovary syndrome.

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Risk of poor neonatal outcome at term after medically assisted reproduction A propensity score matched study

Thursday, July 30, 2015
Term singletons conceived after medically assisted reproduction have an increased risk of morbidity related to birth asphyxia.

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Racial disparities in in vitro fertilization outcomes

Thursday, July 30, 2015
Black and Asian women undergoing in vitro fertilization have significantly lower odds of both clinical intrauterine pregnancy and live birth compared with white women.

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Ectopic pregnancy after in vitro fertilization Differences between fresh and frozen-thawed cycles

Monday, June 29, 2015
We discuss how embryo transfers in cycles without ovarian hyperstimulation are associated with lower rates of ectopic pregnancy compared with fresh autologous cycles, which suggests a difference in the uterine environment.

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Pregnancy related complications and adverse pregnancy outcomes in multiple pregnancies resulting from assisted reproductive technology A meta analysis of cohort studies

Monday, June 1, 2015
We present an up-to-date comparison of pregnancy-related complications and adverse pregnancy outcomes of multiple pregnancies generated with assisted reproductive technology versus spontaneous conception.

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Use of reproductive technology for sex selection for nonmedical reasons

Monday, June 1, 2015
This document discusses the use of reproductive technology to select the sex of offspring for nonmedical reasons.

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Clinical significance of intercellular contact at the four cell stage of human embryos and the use of abnormal cleavage patterns to identify embryos with low implantation potential A time lapse study

Monday, June 1, 2015
Reduced intercellular contact in four-cell stage human embryos leads to compromised subsequent development and implantation potential. Implantation rates could be improved by not selecting embryos showing abnormal cleavage patterns.

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Comparison of live birth defects after luteal phase ovarian stimulation vs conventional ovarian stimulation for in vitro fertilization and vitrified embryo transfer cycles

Wednesday, April 29, 2015
No evidence was found of detrimental effects of luteal-phase ovarian stimulation on live-born infants at birth. Infertility itself and multiple births pose risk factors for congenital malformation.

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Time lapse monitoring of zona pellucida free embryos obtained through in vitro fertilization A retrospective case series

Wednesday, April 29, 2015

Original Video Article

Capsule:
This case series demonstrate that an oocyte with a damaged zona pellucida that has been removed could be successfully fertilized with intracytoplasmic sperm injection, cultured until blastocyst stage in a time-lapse incubator, and vitrified electively for subsequent use.…

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Cost effectiveness analysis of preimplantation genetic screening and in vitro fertilization versus expectant management in patients with unexplained recurrent pregnancy loss

Wednesday, April 29, 2015
In vitro fertilization/preimplantation genetic screening is not cost effective in achieving live birth compared with expectant management in patients with unexplained recurrent pregnancy loss.

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Timing luteal support in assisted reproductive technology A systematic review

Monday, March 30, 2015
Initiation of progesterone for luteal support may impact pregnancy rates (PRs). Starting progesterone before oocyte retrieval or 6 days after retrieval likely decreases PRs.

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Association of number of retrieved oocytes with live birth rate and birth weight An analysis of 231815 cycles of in vitro fertilization

Monday, March 30, 2015
A higher number of retrieved oocytes was associated with an increased incidence of low birth weight in autologous, but not donor, oocyte cycles with fresh transfer of two embryos.

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Congenital anomalies in offspring of subfertile couples A registry based study in the northern Netherlands

Monday, March 30, 2015
This registry-based study suggests that the associations between IVF/ICSI and penoscrotal hypospadia and imprinting disorders reported in the literature are better explained by the underlying subfertility than by IVF/ICSI treatment.

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Outcomes of preimplantation genetic diagnosis in neurofibromatosis type 1

Friday, February 27, 2015

Capsule:
In a retrospective study of patients with neurofibromatosis 1 (NF1) undergoing preimplantation genetic diagnosis, only 37%of all biopsied embryoswere confirmed tobe unaffectedbyNF1, and at least 27%of couples achieved a live birth

Authors:
Vanessa L.…

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Noninvasive embryo viability assessment by quantitation of human haptoglobin alpha 1 fragment in the in vitro fertilization culture medium An additional tool to increase success rate

Friday, February 27, 2015
The measurement of the haptoglobin a-1 fragment in human serum albumin–supplemented culture medium serves as an alternative to assess viability by the exclusion of embryos having low implantation potential.

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