Hypoxia inducible factor and microvessels in peri implantation endometrium of women with recurrent miscarriage

Wednesday, June 1, 2016
Expression of hypoxia inducible factor 1a and vascularization status in peri-implantation endometrium is altered in the nonconception cycles of women with a history of recurrent miscarriage.

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Number of biopsied trophectoderm cells is likely to affect the implantation potential of blastocysts with poor trophectoderm quality

Sunday, May 1, 2016
We found that the implantation potential is negatively affected by the biopsied cell number in blastocysts with poor trophectoderm morphological score.

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Toward a better understanding of the oocyte donation preeclampsia connection

Wednesday, April 13, 2016

Authors:
Frederick Licciardi, M.D.…

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Importance of embryo transfer technique in maximizing assisted reproductive outcomes

Friday, April 1, 2016
Meticulous ET technique, aided by ultrasound guidance, is essential to optimal outcomes with assisted reproductive technology.

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Examining the many potential reasons why euploid blastocysts do not always result in viable pregnancies and deliveries Part 2

Friday, April 1, 2016
A viable delivery requires optimal embryo transfer technique, a receptive and synchronized endometrium, a physiologically and anatomically adequate uterus, and absence of local and circulating factors capable of disrupting implantation.

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Local and systemic factors and implantation What is the evidence

Friday, April 1, 2016
Some medical conditions and lifestyle factors can influence implantation in the setting of IVF. Multiple endometrial and circulating factors affecting implantation will be reviewed.

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Time lapse deselection model for human day 3 in vitro fertilization embryos The combination of qualitative and quantitative measures of embryo growth

Tuesday, March 1, 2016
This study presents a deselection model for human in vitro fertilization embryos independent of the insemination method, the qualitative component being more accurate when coupled with a quantitative component.

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Optimal polar bodies angle for higher subsequent embryo viability A pilot study

Tuesday, March 1, 2016
Noninvasive assessment of polar bodies angle proves to be a practical tool for the selection of viable embryos and should be considered for inclusion in embryo selection parameters.

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Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time lapse system

Monday, February 1, 2016
Blastocyst formation and implantation prediction based on late morphokinetic parameters was developed by using an integrated time-lapse monitoring system.

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Differential expression of vascular endothelial growth factor angiogenic factors in different endometrial compartments in women who have an elevated progesterone level before oocyte retrieval during in vitro fertilization Embryo transfer treatment

Tuesday, September 29, 2015
Altered expression of vascular endothelial growth factor angiogenic factors in peri-implantation endometrium may provide an explanation for the impairment of endometrial receptivity in women who have high P levels before oocyte retrieval.

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Mitochondrial DNA content as a viability score in human euploid embryos Less is better

Tuesday, September 1, 2015
Higher mitochondrial DNA content in euploid human embryos is related to poor implantation potential and may be indicative of reduced metabolic fuel during oocyte maturation.

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Autologous endometrial coculture biopsy Is timing everything

Monday, June 29, 2015
Coculture biopsy in the cycle preceding IVF does not increase implantation, clinical pregnancy, or live birth rates compared with biopsies performed more than one cycle before IVF.

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Are good patient and embryo characteristics protective against the negative effect of elevated progesterone level on the day of oocyte maturation

Monday, June 1, 2015
Elevated P level on the day of human chorionic gonadotropin administration negatively affects live-birth rate, regardless of embryo stage, embryo quality, patient age, or ovarian response.

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External validation of a time lapse prediction model

Monday, March 30, 2015
This external validation study failed to replicate the performance of the time-lapse published prediction model, but it should inspire each center to build its own prediction model.

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Antimullerian hormone as predictor of implantation and clinical pregnancy after assisted conception A systematic review and meta analysis

Monday, December 29, 2014
Antimullerian hormone has weak association with implantation and clinical pregnancy rates in women undergoing ART, but its predictive ability for pregnancy rates is greatest in women with diminished ovarian reserve.

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Prevalence consequence and significance of reverse cleavage by human embryos viewed with the use of the Embryoscope time lapse video system

Monday, July 14, 2014
This study investigated the prevalence and significance of reverse cleavage by human embryos observed via time-lapse monitoring. Embryos showing reverse cleavage were associated with compromised subsequent development and implantation potential.

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Clinical validation of embryo culture and selection by morphokinetic analysis A randomized controlled trial of the EmbryoScope

Wednesday, July 9, 2014
An alternative strategy for embryo selection based on a multivariable morphokinetic model combined with continuous incubation in an integrated timelapse monitoring system improves the clinical results.

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Casting for determinants of blastocyst yield and of rates of implantation and of pregnancy after blastocyst transfers

Monday, June 30, 2014
Numbers of oocytes retrieved and properties of day 3 embryos were predictive of blastocyst formation, implantation, and pregnancy. Patient age and oocyte yields independently impacted implantation rates and uterine receptivity.

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Peri implantation intercourse lowers fecundability

Wednesday, June 25, 2014
Two or more acts of intercourse during the peri-implantation window is associated with a lower probability of pregnancy given prior intercourse during the fertile window.

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Prospective assessment of midsecretory endometrial leukemia inhibitor factor expression versus ανβ3 testing in women with unexplained infertility

Sunday, June 1, 2014
Epithelial LIF expression is reduced in the endometrium of women with UI and is superior to avb3 integrin alone for assessment of endometrial receptivity.

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MicroRNAs and implantation

Sunday, June 1, 2014
This review discusses diagnostic and therapeutic roles of miRNA in implantation. Although promising, further research is needed before miRNA are used in clinical practice for identifying and treating implantation failure.

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Regulation of myeloid ecotropic viral integration site 1 and its expression in normal and abnormal endometrium

Friday, May 23, 2014
Myeloid ecotropic viral integration site 1 (MEIS1) was expressed in response to sex steroid in the endometrium both in vitro and in vivo. Diminished endometrium MEIS1 expression may contribute to implantation failure in endometriosis.

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Association of physical activity in the past year and immediately after in vitro fertilization on pregnancy

Monday, March 31, 2014
Higher self-reported past year physical activity was associated with favorable pregnancy outcomes following in vitro fertilization (IVF). Physical activity and sedentary behavior following IVF were not associated with pregnancy outcomes.

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A multicenter prospective study to assess the effect of early cleavage on embryo quality implantation and live birth rate

Monday, March 31, 2014
The presence of early cleavage does not seem to improve implantation after the usual morphologic evaluation of cleavage-stage embryos.

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The effect of ketorolac on pregnancy rates when used immediately after oocyte retrieval

Friday, August 30, 2013
An analysis of ketorolac use after oocyte retrieval over a 5-year period in a population undergoing in vitro fertilization found no differences in pregnancy outcomes.

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Biomarkers of endometrial receptivity through a minimally invasive approach

Friday, August 30, 2013
Reflections on "Discovery of biomarkers of endometrial receptivity through a minimally invasive approach: a validation study with implications for assisted reproduction" by Chan et al.

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New insights in aneuploidy screening old principles new approaches

Friday, August 30, 2013
Reflections on "Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial" by Scott et al.

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Discovery of biomarkers of endometrial receptivity through a minimally invasive approach a validation study with implications for assisted reproduction

Friday, August 30, 2013
Genomewide gene expression profiling of cells recovered by uterine aspiration can identify robust candidate endometrial receptivity biomarkers while not disrupting implantation, enabling future validation by direct association with clinical outcome.

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Number of supernumerary vitrified blastocysts is positively correlated with implantation and live birth in single blastocyst embryo transfers

Tuesday, April 30, 2013
The number of supernumerary vitrified blastocysts correlates positively with the odds of implantation and live birth in single-blastocyst transfers.

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Is the nuclear status of an embryo an independent factor to predict its ability to develop to term

Thursday, March 28, 2013
Blastomere multinucleation has a negative impact on live birth.

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