Kinetics of the early development of uniparental human haploid embryos

Sunday, May 1, 2016
The early development of human haploid parthenotes and androgenotes in comparison with correctly fertilized eggs (biparentals) showed more kinetic differences according to parental composition than haploidy.

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One uterus bridging three generations First live birth after mother to daughter uterus transplantation

Friday, April 1, 2016

Authors:
Mats Brännström, M.D., Ph.D., Hans Bokström, M.D., Ph.D., Pernilla Dahm-Kähler, M.D., Ph.D., Cesar Diaz-Garcia, M.D., Ph.D., Jana Ekberg, M.D., Ph.D., Anders Enskog, M.D., Ph.D., Henrik Hagberg, M.D., Ph.D., Liza Johannesson, M.D., Ph.D., Niclas Kvarnström, M.D., Johan Mölne, M.D., Ph.D., Michael Olausson, M.D., Ph.D., Jan I.…

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Angiotensin II type 2 receptor is expressed in human sperm cells and is involved in sperm motility

Tuesday, March 1, 2016
Angiotensin II type 2 receptor is present in human spermatozoa and is associated with basic sperm parameters, especially motility.

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Short term hypothermic preservation of human testicular tissue The effect of storage medium and storage period

Friday, January 15, 2016
Human testicular tissue can be preserved for 3 days at 4C in DMEM/F12, without altering tissue morphology, Sertoli cell morphology, number of spermatogonia per area, or number of apoptotic cells.

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Morphokinetics as a predictor of self correction to diploidy in tripronucleated intracytoplasmic sperm injection derived human embryos

Tuesday, September 1, 2015
Tripronucleated-ICSI human embryos (TPN) display different morphokinetic behaviour according to ploidy; TPN-ICSI that self-correct to diploidy are morphokinetically closer to correctly fertilized embryos. The morphokinetic variable t5 can predict ploidy.

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In vitro development of donated frozen thawed human embryos in a prototype static microfluidic device A randomized controlled trial

Friday, February 27, 2015
This study shows that a microfluidic device tested under static conditions supports single-embryo culture of donated frozen-thawed human day-4 embryos to advanced blastocyst stages.

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Choosing the best embryo by time lapse versus standard morphology

Friday, January 30, 2015
Retrospective studies have shown correlation between time-lapse parameters and embryo viability. A recent randomized study has shown improved pregnancy rates. Strict evidence still seems weak.

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Copy number variation associated with meiotic arrest in idiopathic male infertility

Monday, December 29, 2014
In an assessment of the presence of copy number variations (CNV) in men presenting with meiosis arrest and azoospermia, we detected two unique CNVs and several in known meiosis genes.

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A new chapter in the bisphenol A stor Bisphenol S and bisphenol F are not safe alternatives to this compound

Monday, December 29, 2014
Bisphenol S and bisphenol F, which are planned to replace bisphenol A, exhibit similar antiandrogenic effects than bisphenol A in cultured human and mouse testes.

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Ethics of uterus transplantation with live donors

Wednesday, June 25, 2014
Before launching live donor liver transplantation in Chicago, the preparations included thorough ethical discussion, which was subsequently published in The New England Journal of Medicine.

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Single embryo transfer of vitrified warmed blastocysts yields equivalent live birth rates and improved neonatal outcomes compared with fresh transfers

Wednesday, April 30, 2014
After 1,157 fresh and 645 vitrified-warmed day-5 single-blastocyst transfers, we found vitrified warmed blastocysts yielded equivalent birth rates and improved neonatal outcomes compared with fresh transfers.

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Hatching of in vitro fertilized human embryos is influenced by fertilization method

Thursday, October 31, 2013
We describe two distinct mechanisms of in vitro hatching related to fertilization method and demonstrate that hatching pattern is associated with fertilization method, but not with clinical pregnancy.

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Testicular cell transplantation into the human testes

Monday, September 30, 2013
Human cadaver testes were infused with 99mtechnetium-labeled green fluorescent protein-positive testicular cells. This study shows that injecting a cell suspension in seminiferous tubules is possible, though further optimization is required.

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New approach in patients with polycystic ovaries lessons for everyone

Thursday, March 28, 2013
In vitro maturation, including FSH priming, recovery of oocytes from 12-mm follicles, and using single blastocyst transfer, is safe and provides pregnancy rates up to 40% in patients with PCO.

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Blastocyst culture and transfer in clinical assisted reproduction

Friday, March 1, 2013
Blastocyst embryo transfer improves the live-birth rate in good prognosis patients compared with cleavage-stage transfer. In unselected or poor prognosis patients, it is not proven superior to cleavage-stage transfer.

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Effect of oxygen concentration on human embryo development evaluated by time lapse monitoring

Friday, March 1, 2013
With the use of time-lapse monitoring, to evaluate human embryo development, we describe a stage-dependent adverse response to atmospheric oxygen.

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Real time Raman microspectroscopy scanning of the single live sperm bound to human zona pellucida

Friday, March 1, 2013
Raman microspectroscopy scanning of single live sperm is able to distinguish the human zona pellucida–bound sperm from unbound sperm.

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Epithelial cell protein milk fat globule epidermal growth factor 8 and human chorionic gonadotropin regulate stromal cell apoptosis in the human endometrium

Thursday, November 29, 2012
Milk fat globule–epidermal growth factor 8, a multifunctional epithelial protein in the human endometrium, and hCG modulate apoptosis of stromal cells.

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From mice to women and back again Causalities and clues for Chlamydia induced tubal ectopic pregnancy

Thursday, November 1, 2012
Defining the molecular and cellular mechanisms of Chlamydia-induced tubal transport and progression of tubal implantation will be a key question for future studies.

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Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide

Friday, June 8, 2012
A novel role of the opioid system in the regulation of sperm function is demonstrated that shows that both exogenous and endogenous met-enkephalin can modulate sperm motility.

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High expression of luteinizing hormone receptors messenger RNA by human cumulus granulosa cells is in correlation with decreased fertilization

Wednesday, May 23, 2012
This is the first demonstration that LH receptor expression increases during antral follicular growth, is highest in preovulatory follicles, and correlates with fertility treatment outcome.

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