Mitochondrial DNA content as a viability score in human euploid embryos Less is better

Tuesday, September 1, 2015
Higher mitochondrial DNA content in euploid human embryos is related to poor implantation potential and may be indicative of reduced metabolic fuel during oocyte maturation.

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Investigation of gene expression profiles before and after embryonic genome activation and assessment of functional pathways at the human metaphase II oocyte and blastocyst stage

Friday, March 1, 2013
Gene expression profiling at the human oocyte and blastocyst stage has identified similarities and differences in processes before and after embryonic genome activation.

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Identification of a novel gene set in human cumulus cells predictive of an oocytes pregnancy potential

Friday, March 1, 2013
This study identified a 12-gene signature in human cumulus cells predictive of pregnancy across multiple clinics. The positive predictive value of our test was 81% with an area under the receiver operating characteristic of 0.763  0.079.

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Dynamic changes of histone H3 trimethylated at positions K4 and K27 in human oocytes and preimplantation embryos

Thursday, September 27, 2012
The levels of H3K4me3 and H3K27me3 show dynamic changes during human oocyte maturation and embryonic development. Asymmetric distribution of H3K27me3 exists in human zygote pronuclei, whereas H3K4me3 is always uniform.

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