Follicular fluid and mural granulosa cells microRNA profiles vary in in vitro fertilization patients depending on their age and oocyte maturation stage

Tuesday, September 29, 2015
We describe the differential microRNA profiles in the follicular fluid and granulosa cells of in vitro fertilization patients depending on their age and oocyte maturation stage.

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Coenzyme Q dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging

Tuesday, September 1, 2015
Coenzyme Q (CoQ)-dependent mitochondrial activity in granulosa cells reduces with aging and is restored via supplementation, indicating that functional CoQ10 deficit is the main underlying cause for oxidative phosphorylation dysfunction.

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Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation

Tuesday, September 1, 2015
The cannabinoid system is present in human granulosa cells. The expression pattern of each component does not change during oocyte maturation.

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Transgenerational effects of binge drinking in a primate model Implications for human health

Friday, January 30, 2015
Binge drinking affects the developmental potential and gene expression of oocytes. The incidence of binge drinking in women, and its biological effects in primates, indicate an important public health concern.

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Antimüllerian hormone regulates stem cell factor expression in human granulosa cells

Tuesday, November 25, 2014
Antimullerian hormone regulates stem cell factor via the cyclic adenosine 30:50 monophosphate/protein kinase A (cAMP/PKA) pathway in human granulosa cells.

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Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in vitro implications for treatment of ovarian hyperstimulation syndrome with dopamine receptor 2 agonists

Wednesday, April 30, 2014
Dopamine receptor 2 agonists inhibit VEGF secretion in a dose-dependent fashion, which is directly dependent on the amount of D2 expressed by luteinized granulosa cells.

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Generation of multioocyte follicles in the peripubertal rat ovary Link to the invasive capacity of granulosa cells

Wednesday, April 30, 2014
Contrary to previous assumptions, multi-oocyte follicles (MOFs) are frequently observed in the pubertal ovary. Follicle fusion, associated with granulosa cell invasiveness, appears to be the major mechanism for MOF generation.

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Comparison of gene expression profiles in granulosa and cumulus cells after ovulation induction with either human chorionic gonadotropin or a gonadotropin releasing hormone agonist trigger

Monday, September 30, 2013
The follicle transcriptomes after human chorionic gonadatropin and gonadotropin-releasing hormone agonist triggering present significant differences. The top biofunctions represented by the differentially expressed genes were steroidogenesis and angiogenesis in cumulus and mural granulosa cells, respectively.

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Cumulus and granulosa cell markers of oocyte and embryo quality

Monday, March 18, 2013
Retrospective cohort studies correlated changes in cumulus/granulosa cell gene expression with embryo competence. A clinical benefit from the use of identified biomarker genes remains to be demonstrated in randomized trials.

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Effects of resveratrol on growth and function of rat ovarian granulosa cells

Thursday, November 29, 2012
Resveratrol induces cytostatic, but not cytotoxic, effects on granulosa cells, induces a dose-dependent decrease of estradiol production, and reduces vascular endothelial growth factor.

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Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human

Thursday, June 7, 2012
Adiponectin receptors, expressed in mouse and human granulosa cells and cumulus cell-oocyte complexes, mediate differential gene expression in mouse cumulus cells versus granulosa cells and enhance oocyte maturation/embryo development.

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Human granulosa luteal cell OXPHOS function is not affected by age or ovarian response

Thursday, June 7, 2012
The mitochondrial OXPHOS function in the granulosa luteal cells is unaffected by aging or diminishment of the ovarian response.

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Effect of letrozole on estradiol production and P450 aromatase mRNA expression of cultured luteinized granulosa cells from women with and without endometriosis

Thursday, June 7, 2012
Lower estradiol production and P450 aromatase messenger RNA expression of cultured granulosa cells were found in women with endometriosis, but letrozole in the conditioned media further reduced these parameters.

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