Although the controlled ovarian stimulation protocol with short GnRH agonist in alternate days may lower the cost of an individual IVF cycle, it requires more cycles to achieve pregnancy.
AMH predicts oocyte yield and poor and excessive ovarian response in GnRH antagonist cycles and is associated with increased cumulative live-birth rates after single-blastocyst transfer in fresh and cryopreserved cycles.
Treatment with gonadotropin-releasing hormone antagonist improved the clinical, laboratory and ultrasonographic parameters of a pituitary adenoma secreting follicle-stimulating hormone associated with ovarian hyperstimulation which persisted after transsphenoidal surgery.
GnRH antagonist protocols allow friendly IVF procedures for patients but have low convenience to program oocyte retrievals. This study shows that estrogen pretreatment is effective and safe to program antagonist cycles.
Live birth rates and cumulative pregnancy rates were higher in North America than in Europe after treatment with either corifollitropin alfa or daily recombinant FSH in a double-blind prospective randomized controlled trial.
The author discusses the challenges in programming GnRH antagonist cycles.
A randomized, assessor-blind, multicenter trial with compulsory single-blastocyst transfer documented that highly purified hMG is noninferior to rFSH regarding ongoing pregnancy in GnRH antagonist cycles.
Low-dose hCG supplementation after GnRHa trigger secures the reproductive outcome and minimizes the risk of OHSS in the high-risk IVF patient.
GnRH antagonist cycles are associated with a lower risk of OHSS and should be the protocol of choice in high-risk patients; and coasting is a useful protocol for prevention of OHSS.
Fertility & Sterility Discussion Forums