Experimental methods to preserve male fertility and treat male factor infertility

Monday, February 1, 2016
This article describes experimental stem cell and gene therapies that might be used to treat male factor infertility.

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MicroRNAs and spermatogenesis

Sunday, June 1, 2014
This review article summarizes expression and functions of miRNAs during spermatogenesis and their importance in maintaining male fertility, and as potential biomarkers for male factor infertility.

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Levels of the retinoic acid synthesizing enzyme ALDH1A2 are lower in testicular tissue from men with infertility

Monday, March 31, 2014
Levels of aldehyde dehydrogenase-1A2 (ALDH1A2), which synthesizes retinoic acid, are significantly reduced in testicular tissue from men with infertility compared with controls, suggesting an association between ALDH1A2 and male infertility.

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Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1 5 8 signaling

Thursday, October 31, 2013
Bone morphogenetic protein 4 increased oocyte formation from adult mouse ovary-derived oogonial stem cells via activation of Smad1/5/8 signaling and key meiosis commitment genes.

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Germline development from human pluripotent stem cells toward disease modeling of infertility

Wednesday, May 30, 2012
We summarize the recent advances in the human germline development from pluripotent stem cells and discuss the proposed strategies to develop disease models of infertility using human ESC/iPSC.

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Extreme infertility

Wednesday, May 30, 2012
New germ cells and new organs open new areas in the approach to treating infertility.

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