Antimullerian hormone levels decrease in female to male transsexual women using testosterone as cross sex therapy

Wednesday, April 29, 2015
Polycystic ovary syndrome is associated with elevated antimullerian hormone (AMH) levels. In this study, AMH serum levels significantly decreased after androgenic treatment in female-to-male transsexual subjects.

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Elevated non esterified fatty acid concentrations during in vitro murine follicle growth alter follicular physiology and reduce oocyte developmental competence

Tuesday, November 25, 2014
Long-term elevated NEFA concentrations, typical in metabolic disorders, such as obesity or type 2 diabetes, alter follicular growth and physiology, ultimately resulting in reduced oocyte developmental competence in vitro.

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Positive cross talk between FOXL2 and antimüllerian hormone regulates ovarian reserve

Tuesday, May 20, 2014
AMH is an endogenous target gene of FOXL2, and the two factors collaboratively work to reserve ovarian follicles.

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Interpreting human follicular recruitment and antimullerian hormone concentrations throughout life

Thursday, November 1, 2012
The relationships between primordial follicles, follicular recruitment, and circulating AMH are dynamic, reflecting the different stages of the reproductive lifespan. This article discusses these relationships and their clinical implications.

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Androstenedione induces abnormalities in morphology and function of developing oocytes, which impairs oocyte meiotic competence

Thursday, May 31, 2012
Ovarian follicles were cultured individually in vitro with androstenedione. The results demonstrate that excess androgen induces abnormalities in the morphology and function of developing oocytes.

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Smad7 is a transforming growth factor-beta–inducible mediator of apoptosis in granulosa cells

Thursday, May 31, 2012
Overexpression of Smad7 induces increased apoptosis, whereas decreased Smad7 expression reduces apoptosis induced by TGF-b in granulosa cells.

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Developmental programming: prenatal testosterone excess disrupts anti-Müllerian hormone expression in preantral and antral follicles

Thursday, May 24, 2012
Prenatal T leads to changes in anti-Mullerian hormone protein expression that likely accounts for the increased follicular recruitment and persistence found in this animal model of PCOS.

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