Introduction Access to fertility care

Sunday, May 1, 2016
Despite impressive advances in the field of reproductive medicine, access to care is a persisting challenge. These articles explore barriers to fertility care and propose a constructive path forward.

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Effects of maternal age on euploidy in a large cohort of embryos analyzed with 24 chromosome single nucleotide polymorphism based preimplantation genetic screening

Sunday, May 1, 2016
For 37,711 embryos analyzed with 24-chromosome single-nucleotide polymorphism–based preimplantation genetic screening, the number, proportion, and probability of embryos testing as euploid per IVF cycle were stratified by maternal age.

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The impact of fertility treatment on severe maternal morbidity

Thursday, March 24, 2016

Authors:
Erica T. Wang, M.D., M.A.S., John A.…

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Increased risk of incident chronic medical conditions in infertile men Analysis of United States claims data

Tuesday, March 1, 2016
Men diagnosed with male factor infertility had a significantly higher risk of adverse health outcomes in the years after an infertility evaluation.

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Predictors of spermatogenesis in radical orchiectomy specimen and potential implications for patients with testicular cancer

Wednesday, February 24, 2016

Authors:
Ohad Shoshany, M.D., Yariv Shtabholtz, M.D., Eran Schreter, M.D., Maxim Yakimov, M.D., Haim Pinkas, M.D., Anat Stein, Ph.D., Jack Baniel, M.D., Shay Golan, M.D.…

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Experimental methods to preserve male fertility and treat male factor infertility

Monday, February 1, 2016
This article describes experimental stem cell and gene therapies that might be used to treat male factor infertility.

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Short term hypothermic preservation of human testicular tissue The effect of storage medium and storage period

Friday, January 15, 2016
Human testicular tissue can be preserved for 3 days at 4C in DMEM/F12, without altering tissue morphology, Sertoli cell morphology, number of spermatogonia per area, or number of apoptotic cells.

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Changes in sperm methylation profile A potential cause of infertility and a handle to monitor improvements in genetic and lifestyle interactions

Tuesday, December 29, 2015

Authors:
Moira O’Bryan, Ph.D., Michelle Lane, Ph.D.…

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The future of reproductive medicine centers

Tuesday, December 29, 2015

Authors:
Antonio Pellicer, M.D., Daniela Galliano, M.D.…

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Molecular characterization of the human microbiome from a reproductive perspective

Monday, November 30, 2015
Advances in DNA sequencing have led to the understanding that the reproductive tract harbors a symbiotic microbiome. Recent methods for the study of the microbiome in reproduction raise new questions.

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Cancer in women after assisted reproductive technology

Thursday, October 29, 2015
Women initiating treatment with assisted reproduction technology (ART) have no greater short-term risk for developing cancer compared with the general population or other women treated with ART.

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Disparities in access to effective treatment for infertility in the United States An Ethics Committee opinion

Thursday, October 29, 2015
This opinion examines the factors that contribute to disparities in access to fertility care in the United States and proposes actions to address them.

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External validation of the Endometriosis Fertility Index in a French population

Monday, June 29, 2015
The Endometriosis Fertility Index (EFI) predicted spontaneous pregnancy after surgery for endometriotic infertile women. Combining surgery and assisted reproductive technologies according to EFI led to a 78% pregnancy rate at 18 months.

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Perils and promise in big data

Monday, June 1, 2015
Reflections on "Endometriosis and assisted reproductive technology: United States trends and outcomes 2000–2011" by Kawwass et al.

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What to do when the numbers dont add up

Wednesday, April 29, 2015
Reflections on "Does antral follicle count (AFC) predict pregnancy rates in unstimulated therapeutic donor insemination (TDI) cycles?" by Ripley et al.

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Fertility and longevity

Wednesday, April 29, 2015
Natural fertility, infertility and late-age conceptions are associated with longevity. The genetic link and the effect of pregnancy on this phenomenon are summarized in this issue’s Views and Reviews.

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Prospective study of time to pregnancy and adverse birth outcomes

Monday, March 30, 2015
In this registry-based cohort study, we found positive associations between prospectively measured time to pregnancy and several adverse birth outcomes, including preterm birth, low birth weight, placental disorders, gestational diabetes, and cesarean section.

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Relationship between semen production and medical comorbidity

Monday, December 29, 2014
Men with medical comorbidities have a higher rate of abnormal semen parameters.

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Are semen parameters related to birth weight

Friday, December 19, 2014
Birth weight of men with unexplained subfertility is positively correlated with sperm DNA fragmentation in adulthood. In utero environment and its relation to semen parameters may be considered in subfertility.

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Assessment of follicular fluid leptin levels and insulin resistance as outcome predictors in women undergoing in vitro fertilization intracytoplasmic sperm injection

Tuesday, November 25, 2014
High follicular fluid leptin levels were associated with a lower probability of live birth in women undergoing in vitro fertilization–intracytoplasmic sperm injection. Serum progesterone, follicle number, and leptin levels seem to predict IVF outcome.

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Beyond bulk semen parameters

Tuesday, November 25, 2014
What can the analysis of semen reveal about the fertility potential of sperm? A series of articles reviews the current status and limitations of basic and advanced semen testing.

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Why are we still 20 years later depriving human immunodeficiency virus serodiscordant couples of equal access to fertility care

Wednesday, July 30, 2014
Reflections on "Efficacy and safety of intrauterine insemination and assisted reproductive technology in populations serodiscordant for human immunodeficiency virus: a systematic review and meta-analysis" by Barnes et al.

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Efficacy and safety of intrauterine insemination and assisted reproductive technology in populations serodiscordant for human immunodeficiency virus A systematic review and meta analysis

Wednesday, July 30, 2014
A systematic review and meta-analysis for outcomes with intrauterine insemination and in vitro fertilization for HIV-serodiscordant couples found no seroconversions and similar outcomes to HIV-seronegative infertility patients.

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Uterus retrieval process from brain dead donors

Wednesday, July 30, 2014
We describe the feasibility of human uterus retrieval from brain dead donors. Uterus retrieval could be part of a reproducible multiorgan procurement procedure. Uterus donation seems readily accepted.

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Active and passive smoking and fecundability in Danish pregnancy planners

Wednesday, June 25, 2014
Cumulative exposure to active smoking was associated with reduced fecundability among current and former smokers. Time since smoking cessation and passive smoking were not appreciably associated with fecundability.

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Nomograms for predicting changes in semen parameters in infertile men after varicocele repair

Wednesday, June 25, 2014
We formulated nomograms to predict improvements in semen parameters (total motile count, sperm concentration, motility, and morphology) after varicocele repair using multivariable linear regression.

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Laparoscopy for ureteral endometriosis Surgical details long term follow up and fertility outcomes

Wednesday, June 25, 2014
Laparoscopic ureteral shaving for deep endometriosis can be safely and effectively accomplished, with a low risk of complications, encouraging fertility outcomes and a low probability of disease relapse.

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Treatment of pelvic pain associated with endometriosis A committee opinion

Monday, March 31, 2014
Pain associated with endometriosis may involve many mechanisms and requires careful evaluation to confirm the diagnosis and exclude other potential causes. Both medical and surgical treatments for pain related to endometriosis are effective, and choice of treatment must be individualized.

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Later reproductive health after B Lynch sutures A follow up study after 10 years clinical use of the B Lynch suture

Monday, March 31, 2014
The reproductive prognosis after a B-Lynch suture has been placed seems to be good. Nonetheless, complications that might influence future pregnancy may occur, and advice given should address this.

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Current clinical irrelevance of luteal phase deficiency A committee opinion

Sunday, March 30, 2014
This committee opinion addresses controversies regarding the diagnosis and potential treatment of luteal phase inadequacy.

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